- -

Comparison between Hodgkin-Huxley and Markov formulations of cardiac ion channels

RiuNet: Institutional repository of the Polithecnic University of Valencia

Share/Send to

Cited by

Statistics

Comparison between Hodgkin-Huxley and Markov formulations of cardiac ion channels

Show simple item record

Files in this item

dc.contributor.author Carbonell Pascual, Beatriz es_ES
dc.contributor.author Godoy, Eduardo Jorge es_ES
dc.contributor.author Ferrer Albero, Ana es_ES
dc.contributor.author Romero Pérez, Lucia es_ES
dc.contributor.author Ferrero De Loma-Osorio, José María es_ES
dc.date.accessioned 2017-07-11T12:35:40Z
dc.date.available 2017-07-11T12:35:40Z
dc.date.issued 2016-06-21
dc.identifier.issn 0022-5193
dc.identifier.uri http://hdl.handle.net/10251/84919
dc.description.abstract When simulating the macroscopic current flowing through cardiac ion channels, two mathematical formalisms can be adopted: the Hodgkin–Huxley model (HHM) formulation, which describes openings and closings of channel ‘gates’, or the Markov model (MM) formulation, based on channel ‘state’ transitions. The latter was first used in 1995 to simulate the effects of mutations in ionic currents and, since then, its use has been extended to wild-type channels also. While the MMs better describe the actual behavior of ion channels, they are mathematically more complex than HHMs in terms of parameter estimation and identifiability and are computationally much more demanding, which can dramatically increase computational time in large-scale (e.g. whole heart) simulations. We hypothesize that a HHM formulation obtained from classical patch-clamp protocols in wild-type and mutant ion channels can be used to correctly simulate cardiac action potentials and their static and dynamic properties. To validate our hypothesis, we selected two pivotal cardiac ionic currents (the rapid delayed rectifier Kþ current, IKr, and the inward Naþ current, INa) and formulated HHMs for both wild-type and mutant channels (LQT2- linked T474I mutation for IKr and LQT3-linked ΔKPQ mutation for INa). Action potentials were then simulated using the MM and HHM versions of the currents, and the action potential waveforms, biomarkers and action potential duration rate dependence properties were compared in control conditions and in the presence of physiological variability. While small differences between ionic currents were found between the two models (correlation coefficient ρ40.92), the simulations yielded almost identical action potentials (ρ40.99), suggesting that HHMs may also be valid to simulate the effects of mutations affecting IKr and INa on the action potential. es_ES
dc.description.sponsorship This work was partially supported by the "VI Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica" from the Ministerio de Economia y Competitividad of Spain (TIN2012-37546-C03-01) and the European Commission (European Regional Development Funds - ERDF - FEDER). en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation Ministerio de Economía y Competitividad (Spain), “VI Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica” TIN2012- 37546-C03-01 es_ES
dc.relation European Commission (European Regional Development Funds – ERDF - FEDER) es_ES
dc.relation.ispartof Journal of Theoretical Biology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Computational modeling es_ES
dc.subject Ionic current es_ES
dc.subject Cardiac action potential es_ES
dc.subject Hodgkin-Huxley es_ES
dc.subject Markov es_ES
dc.subject Ion channel mutation es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Comparison between Hodgkin-Huxley and Markov formulations of cardiac ion channels es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.jtbi.2016.03.039
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Carbonell Pascual, B.; Godoy, EJ.; Ferrer Albero, A.; Romero Pérez, L.; Ferrero De Loma-Osorio, JM. (2016). Comparison between Hodgkin-Huxley and Markov formulations of cardiac ion channels. Journal of Theoretical Biology. 399:92-102. doi:10.1016/j.jtbi.2016.03.039 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.jtbi.2016.03.039 es_ES
dc.description.upvformatpinicio 92 es_ES
dc.description.upvformatpfin 102 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 399 es_ES
dc.relation.senia 314860 es_ES
dc.identifier.eissn 1095-8541


This item appears in the following Collection(s)

Show simple item record