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dc.contributor.author | Flores Pedauye, Ricardo | es_ES |
dc.contributor.author | Ruiz Ruiz, Susana | es_ES |
dc.contributor.author | Serra Alfonso, Pedro | es_ES |
dc.date.accessioned | 2017-09-21T07:45:22Z | |
dc.date.available | 2017-09-21T07:45:22Z | |
dc.date.issued | 2012-08 | |
dc.identifier.issn | 0272-8087 | |
dc.identifier.uri | http://hdl.handle.net/10251/87706 | |
dc.description.abstract | [EN] There is a subviral world, whose most prominent representatives are viroids. Despite being solely composed by a circular, highly structured RNA of 250 to 400 nucleotides without protein-coding ability (all viruses code for one or more proteins), viroids can infect and incite specific diseases in higher plants. The RNA of human hepatitis delta virus (HDV), the smallest genome of an animal virus, displays striking similarities with viroids: It is circular, folds into a rodlike secondary structure, and replicates through a rolling-circle mechanism catalyzed by host enzymes and cis-acting ribozymes. However, HDV RNA is larger ( 1700 nucleotides), encodes a protein in its antigenomic polarity (the ∂ antigen), and depends for transmission on hepatitis B virus. The presence of ribozymes in some viroids and in HDV RNA, along with their structural simplicity, makes them candidates for being molecular fossils of the RNA world that presumably preceded our extant world based on DNA and proteins. | es_ES |
dc.description.sponsorship | Recent work in Dr. Flores laboratory has been supported by grants BFU2008-03154 and BFU2011-28443 from the Ministerio de Educacion y Ciencia (MEC) of Spain. Dr. P. Serra has been supported by the Generalitat Valenciana (APOSTD 2010, Program VALi+d) and the MEC (Program Juan de la Cierva). | |
dc.language | Inglés | es_ES |
dc.publisher | Thieme Publishing | es_ES |
dc.relation.ispartof | Seminars in Liver Disease | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Viroids | es_ES |
dc.subject | Hepatitis delta virus | es_ES |
dc.subject | Subviral pathogens | es_ES |
dc.subject | Rolling-circle replication | es_ES |
dc.subject | Ribozymes | es_ES |
dc.title | Viroids and Hepatitis Delta Virus | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1055/s-0032-1323624 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//BFU2008-03154/ES/INTERACCIONES VIROIDE-HUESPED: PAPEL DE LAS RIBOZIMAS, DEL SILENCIAMIENTO MEDIADO POR RNA, Y DE LA RECOMBINACION DE RNA/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//BFU2011-28443/ES/VIROIDES: DOMINIOS ESTRUCTURALES, INICIACION DE LA TRANSCRIPCION, INTERACCION CON PROTEINAS ARGONAUTAS DEL HUESPED, Y TASAS DE MUTACION/ | |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes | es_ES |
dc.description.bibliographicCitation | Flores Pedauye, R.; Ruiz Ruiz, S.; Serra Alfonso, P. (2012). Viroids and Hepatitis Delta Virus. Seminars in Liver Disease. 32(3):201-210. https://doi.org/10.1055/s-0032-1323624 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://doi.org/10.1055/s-0032-1323624 | es_ES |
dc.description.upvformatpinicio | 201 | es_ES |
dc.description.upvformatpfin | 210 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 32 | es_ES |
dc.description.issue | 3 | es_ES |
dc.relation.senia | 233300 | es_ES |
dc.identifier.pmid | 22932968 | |
dc.contributor.funder | Ministerio de Ciencia e Innovación |