Montesinos Magraner, MarcVila, CarlosCantón, RubénBlay, GonzaloFernández, IsabelMuñoz Roca, María del CarmenPedro, José R.2016-10-192016-10-1920151433-7851https://riunet.upv.es/handle/10251/72285A quinine-derived thiourea organocatalyst promoted the highly enantioselective addition of naphthols and activated phenols to ketimines derived from isatins. The reaction afforded chiral 3-amino-2-oxindoles with a quaternary stereocenter in high yields (up to 99%) with excellent enantioselectivity (up to 99% ee). To the best of our knowledge, this transformation is the first highly enantioselective addition of naphthols to ketiminesReserva de todos los derechosAsymmetric synthesisFriedel-Crafts reactionsIsatin-derived ketiminesNaphtholsOrganocatalysisFISICA APLICADAOrganocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted StereocentersArtículo10.1002/anie.201501273Cerrado1521-3773