Hervàs-Arnandis, SusiGarnes-Portoles, FranciscoRodríguez-Nuévalos, SilviaOliver-Meseguer, JuditLeyva Perez, Antonio2025-09-042025-09-042025-07-162041-1723https://riunet.upv.es/handle/10251/225458[EN] Researchers have investigated for decades a suitable catalyst to selectively synthesize epoxides from alkenes with air. Here we show that a selective aerobic epoxidation of industrial alkyl alkenes in liquid phase occurs without any catalyst, solvent nor additive, just placing the neat alkene under 3-5 bar of O2 and heating between 100 and 200 degrees C. The reaction can be performed in either an autoclave, a stirring vessel with air bubbling or even a simple open flask, provided that any metal piece is not in contact with the reaction. Alkyl epoxides are directly obtained, after air venting, in yields and selectivity up to 90%. The simplicity of the set-up (just the neat liquid alkene and air) allows to engage the epoxidation reaction with either a previous alkene formation (upstreaming) or a later epoxide opening (downstreaming) reactions, to achieve a variety of industrially-relevant organic products in one-pot.Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)EpoxidesAlkyl alkenesUncatalyzed aerobic epoxidationArtículo10.1038/s41467-025-61711-3Abierto