Tormos Faus, Rosa EsperanzaBosca Mayans, Francisco2016-10-042016-10-0420132046-2069https://riunet.upv.es/handle/10251/71083It has been observed for the first time that the binding of tropolone derivatives to human serum albumin (HSA) produce a high fluorescence promotion. Important evidence of the immobilization of these drugs into the protein has been found by UV-vis spectrometry. Moreover, the literature contradictions about the interactions between colchicine and HSA have been unequivocally resolved.Reserva de todos los derechosHUMAN-SERUM-ALBUMINHINOKITIOL-RELATED COMPOUNDSCOLCHICINEPHOTOPHYSICSPHARMACOLOGYINHIBITIONBOVINEDRUGQUIMICA ORGANICAAntineoplastic tropolone derivatives as useful biomarkers: fluorescence enhancement upon binding to biological targetsArtÃculo10.1039/c3ra42122hCerrado