Wu, BeileiBlanchard-Letort, AlexandraLiu, YanZhou, GuangheWang, XifengElena Fito, Santiago Fco2013-05-062013-05-0620111932-6203https://riunet.upv.es/handle/10251/28590[EN] Barley yellow dwarf virus (BYDV) species PAV occurs frequently in irrigated wheat fields worldwide and can be efficiently transmitted by aphids. Isolates of BYDV-PAV from different countries show great divergence both in genomic sequences and pathogenicity. Despite its economical importance, the genetic structure of natural BYDV-PAV populations, as well as of the mechanisms maintaining its high diversity, remain poorly explored. In this study, we investigate the dynamics of BYDV-PAV genome evolution utilizing time-structured data sets of complete genomic sequences from 58 isolates from different hosts obtained worldwide. First, we observed that BYDV-PAV exhibits a high frequency of homologous recombination. Second, our analysis revealed that BYDV-PAV genome evolves under purifying selection and at a substitution rate similar to other RNA viruses (3.158x10(-4) nucleotide substitutions/site/year). Phylogeography analyses show that the diversification of BYDV-PAV can be explained by local geographic adaptation as well as by host-driven adaptation. These results increase our understanding of the diversity, molecular evolutionary characteristics and epidemiological properties of an economically important plant RNA virus.Reconocimiento (by)Plant RNA virusesRecombinationSequencesDNAPhylogeniesHypothesisPhenotypesAlignmentSerotypeRatesDynamics of molecular evolution and phylogeography of Barley yellow dwarf virus-PAVArtÃculo10.1371/journal.pone.0016896Abierto21326861PMC3033904