De Munck, LodeVila, CarlosMuñoz Roca, María Del CarmenPedro, José R.2017-03-202017-03-202016-12-050947-6539https://riunet.upv.es/handle/10251/78864A catalytic highly enantioselective aza-Reformatsky reaction with cyclic aldimines and ketimines for the synthesis of chiral b-amino esters with good yields and excellent enantioselectivities is reported.Areadily available diaryl prolinol is used as a chiral ligand, ZnMe2 as a zinc source and ethyl iodoacetate as reagent in the presence of air atmosphere. The reaction with cyclic ketimines generates a quaternary stereocenter with excellent levels of enantioselectivity. Furthermore, five-membered N-sulfonyl ketimines were used as electrophiles with good enantiomeric excesses, under the optimized reaction conditions. Moreover, several chemical transformations were performed with the chiral b-amino esters.Reserva de todos los derechosAsymmetric catalysisCyclic ketiminesReformatsky reactionZincBeta-amino esterFISICA APLICADAArtículo10.1002/chem.201604606Cerrado1521-3765