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Listar por autor "Liu, Wanlu"

Mostrando ítems 1-8 de 8

A DNA methylation reader complex that enhances gene transcription

Harris, C. Jake; Scheibe, Marion; Wongpalee, Somsakul Pop; Liu, Wanlu; Cornett, Evan M.; Vaughan, Robert M.; Li, Xueqin; Chen, Wei; Xue, Yan; Zhong, Zhenhui; Yen, Linda; Barshop, William D.; Rayatpisheh, Shima; Gallego Bartolomé, Javier; Groth, Martin (American Association for the Advancement of Science (AAAS), 2018-12-07)

[EN] DNA methylation generally functions as a repressive transcriptional signal, but it is also known to activate gene expression. In either case, the downstream factors remain largely unknown. By using comparative ...
A One Precursor One siRNA Model for Pol IV-Dependent siRNA Biogenesis.

Zhai, Jixian; Bischof, Sylvain; Wang, Haifeng; Feng, Suhua; Lee, Tzuu-Fen; Teng, Chong; Chen, Xinyuan; Park, Soo Young; Liu, Linshan; Gallego Bartolomé, Javier; Liu, Wanlu; Henderson, Ian R; Meyers, Blake C.; Ausin, Israel; Jacobsen, Steven E. (Elsevier, 2015-10-08)

[EN] RNA-directed DNA methylation in Arabidopsis thaliana is driven by the plant-specific RNA Polymerase IV (Pol IV). It has been assumed that a Pol IV transcript can give rise to multiple 24-nt small interfering RNAs ...
Co-targeting RNA Polymerases IV and V Promotes Efficient De Novo DNA Methylation in Arabidopsis

Gallego Bartolomé, Javier; Liu, Wanlu; Kuo, Peggy Hsuanyu; Feng, Suhua; Ghoshal, Basudev; Gardiner, Jason; Zhao, Jenny Miao-Chi; Park, Soo Young; Chory, Joanne; Jacobsen, Steven E. (Elsevier, 2019-02-21)

[EN] The RNA-directed DNA methylation (RdDM) pathway in plants controls gene expression via cytosine DNA methylation. The ability to manipulate RdDM would shed light on the mechanisms and applications of DNA methylation ...
CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation

Wongpalee, Somsakul Pop; Liu, Shiheng; Gallego Bartolomé, Javier; Leitner, Alexander; Aebersold, Ruedi; Liu, Wanlu; Yen, Linda; Nohales, Maria A.; Kuo, Peggy Hsuanyu; Vashisht, Ajay A.; Wohlschlegel, James A.; Feng, Suhua; Kay, Steve A.; Zhou, Z. Hong; Jacobsen, Steven E. (Nature Publishing Group, 2019-09-02)

[EN] Transcription by RNA polymerase V (Pol V) in plants is required for RNA-directed DNA methylation, leading to transcriptional gene silencing. Global chromatin association of Pol V requires components of the DDR complex ...
DNA methylome of the 20-gigabase Norway spruce genome.

Ausin, Israel; Feng, Suhua; Yu, Chaowei; Liu, Wanlu; Kuo, Hsuan Yu; Jacobsen, Elise L.; Zhai, Jixian; Gallego Bartolomé, Javier; Wang, Lin; Egertsdotter, Ulrika; Street, Nathaniel R.; Jacobsen, Steven E.; Wang, Haifeng (Proceedings of the National Academy of Sciences, 2016-12-13)

[EN] DNA methylation plays important roles in many biological processes, such as silencing of transposable elements, imprinting, and regulating gene expression. Many studies of DNA methylation have shown its essential roles ...
Ectopic targeting of CG DNA methylation in Arabidopsis with the bacterial SssI methyltransferase

Liu, Wanlu; Gallego Bartolomé, Javier; Zhou, Yuxing; Zhong, Zhenhui; Wang, Ming; Wongpalee, Somsakul Pop; Gardiner, Jason; Feng, Suhua; Kuo, Peggy Hsuanyu; Jacobsen, Steven E. (Nature Publishing Group, 2021-05-25)

[EN] The ability to target epigenetic marks like DNA methylation to specific loci is important in both basic research and in crop plant engineering. However, heritability of targeted DNA methylation, how it impacts gene ...
RNA-directed DNA methylation involves co-transcriptional small-RNA-guided slicing of polymerase V transcripts in Arabidopsis

Liu, Wanlu; Duttke, Sascha H.; Hetzel, Jonathan; Groth, Martin; Feng, Suhua; Gallego Bartolomé, Javier; Zhong, Zhenhui; Kuo, Hsuan Yu; Wang, Zonghua; Zhai, Jixian; Chory, Joanne; Jacobsen, Steven E. (Nature Publishing Group, 2018-05)

[EN] Small RNAs regulate chromatin modifications such as DNA methylation and gene silencing across eukaryotic genomes. In plants, RNA-directed DNA methylation (RdDM) requires 24-nucleotide small interfering RNAs (siRNAs) ...
Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain

Gallego Bartolomé, Javier; Gardiner, Jason; Liu, Wanlu; Papikian, Ashot; Ghoshal, Basudev; Kuo, Hsuan Yu; Zhao, Jenny Miao-Chi; Segal, David J.; Jacobsen, Steven E. (Proceedings of the National Academy of Sciences, 2018-02-27)

[EN] DNA methylation is an important epigenetic modification involved in gene regulation and transposable element silencing. Changes in DNA methylation can be heritable and, thus, can lead to the formation of stable ...