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Listar por autor "Salmerón Sánchez, Manuel"

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A fractal nature for polymerized laminin

Hochman Méndez, Carlos; Cantini ., Marco; Moratal Pérez, David; Salmerón Sánchez, Manuel; Coelho-Sampaio, Tatiana (Public Library of Science, 2014-10)

Polylaminin (polyLM) is a non-covalent acid-induced nano- and micro-structured polymer of the protein laminin displaying distinguished biological properties. Polylaminin stimulates neuritogenesis beyond the levels achieved ...
A Hydrogel Platform that Incorporates Laminin Isoforms for Efficient Presentation of Growth Factors - Neural Growth and Osteogenesis

Dobre, Oana; Oliva, Mariana A. G.; Ciccone, Giuseppe; Trujillo-Muñoz, Sara; Rodrigo Navarro, Aleixandre; Venters, Douglas Cormac; Llopis Hernández, Virginia; Vassalli, Massimo; González García, Cristina; Dalby, Matthew J.; Salmerón Sánchez, Manuel (John Wiley & Sons, 2021-05)

[EN] Laminins (LMs) are important structural proteins of the extracellular matrix (ECM). The abundance of every LM isoform is tissue-dependent, suggesting that LM has tissue-specific roles. LM binds growth factors (GFs), ...
A tough act to follow: collagen hydrogel modifications to improve mechanical and growth factor loading capabilities

Sarrigiannidis, S.O.; Rey, J. M.; Dobre, O .; González-García, C.; Dalby, M.J.; Salmerón Sánchez, Manuel (Elsevier, 2021-03)

[EN] Collagen hydrogels are among the most well-studied platforms for drug delivery and in situ tissue engineering, thanks to their low cost, low immunogenicity, versatility, biocompatibility, and similarity to the natural ...
Arrangement of Type IV Collagen and Laminin on Substrates with Controlled Density of ¿OH Groups

Coelho, Nuno Miranda; González García, Cristina; Salmerón Sánchez, Manuel; Altankov, George (Mary Ann Liebert, 2011)

Collagen IV (Col IV) and laminin (Lam) are the main structural components of the basement membrane where they form two overlapping polymeric networks. We studied the adsorption pattern of these proteins on five model ...
Arrangement of Type IV Collagen on NH2 and COOH Functionalized Surfaces

Miranda Coelho, Nuno; González García, Cristina; Salmerón Sánchez, Manuel; Altankov, George (Wiley-Blackwell, 2011-07)

Apart from the paradigm that cell-biomaterials interaction depends on the adsorption of soluble adhesive proteins we anticipate that upon distinct conditions also other, less soluble ECM proteins such as collagens, associate ...
Biochemical- and Biophysical-Induced Barriergenesis in the Blood¿Brain Barrier: A Review of Barriergenic Factors for Use in In Vitro Models

Schofield, Christina L.; Rodrigo-Navarro, Aleixandre; Dalby, Matthew J.; Van Agtmael, Tom; Salmerón Sánchez, Manuel (Wiley-VCH Verlag GmbH & Co. KGaA, 2021-05)

[EN] Central nervous system (CNS) pathologies are a prevalent problem in aging populations, creating a need to understand the underlying events in these diseases and develop efficient CNS-targeting drugs. The importance ...
Biodegradable poly(L-lactide) and polycaprolactone block copolymer networks

Escobar Ivirico, Jorge Luis; Salmerón Sánchez, Manuel; Gómez Ribelles, José Luís; Monleón Pradas, Manuel (Wiley, 2011)

New biodegradable block copolymer networks were synthesized from methacrylate-terminated poly(L-lactide) (mLA) and polycaprolactone (mCL) macromers. This allowed the realization of a series of materials in which the macromer ...
BIOLOGICAL ACTIVITY OF FIBRONECTIN AT THE CELL-MATERIAL INTERFACE

González García, Cristina (Universitat Politècnica de València, 2012-11-05)

Esta tesis aborda la actividad biológica de la fibronectina (FN) como proteína de interfase en la interacción célula-material. La tesis investiga la respuesta de la proteína, en términos de cantidad adsorbida y conformación, ...
Biological activity of the substrate-induced fibronectin network: Insight into the third dimension through electrospun fibers

Gugutkov, Dencho; González-García, Cristina; Rodríguez Hernández, José Carlos; Altankov, George; Salmerón Sánchez, Manuel (American Chemical Society, 2009)

[EN] Fibronectin (FN) fibrillogenesis is a cell-mediated process involving integrin activation that results in conformational changes of FN molecules and the organization of actin cytoskeleton. A similar process can be ...
Biomimetic injectable hydrogels of gelatin and hyaluronic acid for hepatic cell culture

Rodríguez Fernández, Julio (Universitat Politècnica de València, 2024-09-02)

[ES] La ingeniería tisular hepática ofrece una herramienta propicia de cribado toxicológico y modelización de enfermedades, que también podría proporcionar una terapia alternativa al trasplante de hígado para tratar ...
Biophysical phenotyping of mesenchymal stem cells along the osteogenic differentiation pathway

Gavazzo, Paola; Viti, Federica; Donnelly, Hannah; Gonzalez Oliva, Mariana Azevedo; Salmerón Sánchez, Manuel; Dalby, Matthew J.; Vassalli, Massimo (Springer-Verlag, 2021-12)

[EN] Mesenchymal stem cells represent an important resource, for bone regenerative medicine and therapeutic applications. This review focuses on new advancements and biophysical tools which exploit different physical and ...
Borax induces osteogenesis by stimulating NaBC1 transporter via activation of BMP pathway

Rico Tortosa, Patricia María; Rodrigo Navarro, Aleixandre; Sánchez-Pérez, Laura; Salmerón Sánchez, Manuel (Springer Nature, 2020-11-27)

[EN] The intrinsic properties of mesenchymal stem cells (MSCs) make them ideal candidates for tissue engineering applications. Efforts have been made to control MSC behavior by using material systems to engineer synthetic ...
Chondrocytes cultured in an adhesive macroporous scaffold subjected to stirred flow bioreactor behave like in static culture

Gamboa Martínez, Tatiana Carolina; Ródenas Rochina, Joaquín; Rico Tortosa, Patricia María; Lebourg, Myriam Madeleine; Gómez Ribelles, José Luís; Salmerón Sánchez, Manuel; Gallego-Ferrer, Gloria (American Scientific Publishers, 2013)

[EN] The aim of this study was to evaluate whether mechanical stimulation helps to modulate the redifferentiation of human chondrocytes on adhesive 3D substrates. In a previous work, it was shown that chondrocytes seeded ...
Comportamiento mecánico de tres tipos de anudados quirúrgicos usando monofilamentos de 4/0

Gil Santos, Luis; Más Estellés, Jorge; Salmerón Sánchez, Manuel; Barrios, Carlos (Elsevier, 2012-07)

[ES] Objetivo Estudiar experimentalmente mediante ensayos mecánicos el comportamiento de 4 tipos de monofilamento con 3 diseños de nudo, muy frecuentemente utilizados en cirugía. Material y métodos Se eligieron 4 ...
Confined Sandwichlike Microenvironments Tune Myogenic Differentiation

Ballester Beltrán, José; Trujillo, Sara; Alakpa, Enateri V.; Compañ Moreno, Vicente; Gavara, Rafael; Meek, Dominic; West, Christopher C.; Peault, Bruno; Dalby, Matthew J.; Salmerón Sánchez, Manuel (American Chemical Society, 2017)

[EN] Sandwichlike (SW) cultures are engineered as a multilayer technology to simultaneously stimulate dorsal and ventral cell receptors, seeking to mimic cell adhesion in three-dimensional (3D) environments in a reductionist ...
Control de las propiedades mecánicas en materiales soporte para terapias regenerativas

Cantos Gómez, Antonio (Universitat Politècnica de València, 2013-12-10)

Consulta en la Biblioteca ETSI Industriales (7872)
Controlled Assembly of Fibronectin Nanofibrils Triggered by Random Copolymer Chemistry

MNATSAKANYAN, HAYK; Rico Tortosa, Patricia María; Grigoriou, Eleni; Maturana Candelas, Aarón; Rodrigo Navarro, Aleixandre; Salmerón Sánchez, Manuel; Sabater i Serra, Roser (American Chemical Society, 2015-08-19)

Fibronectin fibrillogenesis is the physiological process by which cells elaborate a fibrous FN matrix. Poly(ethyl acrylate), PEA, has been described to induce a similar process upon simple adsorption of fibronectin (FN) ...
Controlled wettability, same chemistry: biological activity of plasma-polymerized coatings

Cantini, Marco; Rico Tortosa, Patricia María; Moratal Pérez, David; Salmerón Sánchez, Manuel (Royal Society of Chemistry, 2012)

Plasma polymerization was used to produce novel nanometric coatings able to direct fibronectin adsorption and cell response. Using ethyl acrylate as a monomer, we obtain coatings whose chemical composition maintains some ...
Desarrollo de una herramienta informática para la predicción de la absorción competitiva en ingeniería de superficies para aplicaciones biomédicas

Hernández Saz, Jesús (Universitat Politècnica de València, 2013-12-10)

Consulta en la Biblioteca ETSI Industriales (7864)
Differentiation of Human Mesenchymal Stem Cells Toward Quality Cartilage Using Fibrinogen-Based Nanofibers

Forget, Jeremy; Awaja, Firas; Gugutkov, Dencho; Gustavsson, Juhan; Gallego-Ferrer, Gloria; Coelho-Sampaio, Tatiana; Hochman-Mendez, Camila; Salmerón Sánchez, Manuel; Altankov, George (Wiley, 2016-09)

[EN] Mimicking the complex intricacies of the extra cellular matrix including 3D configurations and aligned fibrous structures were traditionally perused for producing cartilage tissue from stem cells. This study shows ...