Pérez Ruiz, Raul; Molins-Molina, Oscar; Lence, Emilio; González-Bello, Concepción; Miranda Alonso, Miguel Ángel; Jiménez Molero, María Consuelo(American Chemical Society, 2018-11-02)
[EN] Latent electrophiles are nowadays very attractive chemical entities for drug discovery, as they are unreactive unless activated upon binding with the specific target. In this work, the utility of 4-trifluoromethyl ...
Vayá Pérez, Ignacio; Andreu Ros, María Inmaculada; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2014)
The photooxygenation of model compounds containing the two enantiomers of naproxen (NPX) covalently
linked to histidine (His), tryptophan (Trp) and tyrosine (Tyr) has been investigated by steady state
irradiation, ...
Castellanos-Soriano, Jorge; Álvarez-Gutiérrez, Daniel; Jiménez Molero, María Consuelo; Pérez-Ruiz, Raúl(The Royal Society of Chemistry, 2022-07)
[EN] In this work, the feasibility of triplet fusion upconversion (TFU, also named triplet-triplet annihilation upconversion) technology for the functionalization (arylation) of furans and thiophenes has been successfully ...
Herrera Luna, Jorge Carlos(Universitat Politècnica de València, 2023-01-05)
[ES] En la presente tesis doctoral se describen metodologías novedosas, simples y rápidas con luz visible para producir compuestos con nuevos enlaces C-heteroátomo como C-B, C-P y C-S que representan estructuras valiosas ...
Monje López, Vicente Tomás(Universitat Politècnica de València, 2014-09-30)
[EN] Proteins are macromolecules considered unique because of its complex spatial structure and diversity of roles in biological systems. Some years ago many of these structures are known in detail, and also the mechanisms ...
Herrera-Luna, Jorge Carlos; Sampedro, Diego; Jiménez Molero, María Consuelo; Pérez-Ruiz, Raúl(American Chemical Society, 2020-04-17)
[EN] Boron-containing thiophenes are important entities in organic/medicinal chemistry as well as in material science. In this Letter, a novel, straightforward, and fast procedure for their production employing visible ...
Castellanos-Soriano, Jorge; Herrera-Luna, Jorge Carlos; Díaz Díaz, David; Jiménez Molero, María Consuelo; Pérez-Ruiz, Raúl(Royal Society of Chemistry, 2020-07-07)
[EN] Currently, evolution of chemical transformations by visible light irradiation is highly desirable from cost, safety, availability, and environmental friendliness points of view. Besides, activation of less reactive ...
[EN] The palladium-catalysed cross-coupling reaction between alkenes and aryl halides (the Mizoroki-Heck reaction) is a powerful methodology to construct new carbon-carbon bonds. However, the success of this reaction is ...
Limones Herrero, Daniel; Pérez Ruiz, Raúl; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(Wiley, 2014-10)
Cyamemazine (CMZ) is a neuroleptic drug that mediates cutaneous phototoxicity in humans. Here, the photobehavior of CMZ has been examined within (1)-acid glycoproteins, - and -cyclodextrins and SDS micelles. In all these ...
Pérez Ruiz, Raúl; Sáez Cases, José Antonio; Domingo, Luis R.; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2012)
The radical anions of azetidin-2-ones, generated by UV-irradiation in the presence of triethylamine, undergo ring-splitting via N-C4 or C3-C4 bond breaking, leading to open-chain amides. This reactivity diverges from that ...
Molins-Molina, Oscar; Bresolí-Obach, Roger; García-Laínez, G.; Andreu Ros, María Inmaculada; Nonell, Santiago; Miranda Alonso, Miguel Ángel; Jiménez Molero, María Consuelo(John Wiley & Sons, 2017-09)
[EN] Singlet oxygen photosensitization (studied by time-resolved near-infrared emission spectroscopy) and in vitro phototoxicity (by means of the 3T3 neutral red uptake assay) have been investigated for the prodrugs ...
Belda Marqués, Núria(Universitat Politècnica de València, 2021-10-06)
[ES] En este trabajo de fin de grado se han sintetizado nanopartículas esféricas de oro (AuNPs) con
un diámetro de 2-4 nm, las cuales han sido funcionalizadas con polietilenglicol (PEG), diferentes
proteínas (HSA, BSA, ...
Bernal Martí, Andrés(Universitat Politècnica de València, 2021-10-05)
[ES] Las β-lactamas son amidas cíclicas que presentan un importante interés biológico y
médico ya que son el núcleo de muchas clases de antibióticos. Además, muestran un
interés considerable en síntesis orgánica como ...
Garrido García, Emilio José(Universitat Politècnica de València, 2022-10-27)
[ES] Las escuaramidas son sustratos que han proporcionado buenos resultados en el campo de la
organocatálisis debido a sus estructuras planas rígidas y su característica de donante en la formación
de enlaces de hidrógeno. ...
Mateos Pujante, Alejandro(Universitat Politècnica de València, 2018-10-16)
[ES] En este trabajo se ha sintetizado el metabolito de fase I del antiinflamatorio no esteroideo
naproxeno, el ácido 6-hidroxi-2-naftil propanoico, y se ha llevado a cabo su caracterización fotofísica
y fotoquímica, ...
Alonso Ruiz, Rafael; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(American Chemical Society, 2011)
[EN] Encapsulation within transport proteins strongly reduces the photooxidation rate of (S)- and (R)-2-(9-anthracenyl)propanoic acid (1) and results in
a significant stereodifferentiation. The most remarkable effects are ...
Vayá Pérez, Ignacio; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(Elsevier, 2005)
[EN] Three stereoisomeric salts of naproxen (NPX) with arginine (Arg), namely (S)-NPX/(S)-Arg, (R)-NPX/(S)-Arg and (S)NPX/(R)-Arg, have been prepared, and their fluorescence spectra recorded in solution and in the solid ...
Bonancía Roca, Paula; Vayá Pérez, Ignacio; Markovitsi, Dimitra; Gustavsson, Thomas; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2013)
The photochemical processes occurring in diastereomeric dyads (S, S)-1 and (S, R)-1, prepared by conjugation of (S)-2-(2-hydroxy-1,1'-biphenyl-4-yl) propanoic acid ((S)-BPOH) with (S)- and (R)-Trp, have been investigated. ...
Lammers, Ivonne; Lhiaubet, Virginie Lyria; Jiménez Molero, María Consuelo; Ariese, Freek; Miranda Alonso, Miguel Ángel; Gooijer, Cees(Wiley, 2012-10)
The interaction of the nonsteroidal anti-inflammatory drug flurbiprofen (FBP) with human serum albumin (HSA) hardly influences the fluorescence of the protein's single tryptophan (Trp). Therefore, in addition to fluorescence, ...
Tormos Belda, Mireia(Universitat Politècnica de València, 2022-10-03)
[ES] La creciente concienciación por parte de la sociedad sobre el problema que supone seguir contaminando el planeta al ritmo actual, ha aumentado la importancia de buscar alternativas sostenibles a los combustibles ...