[EN] Mot3 and Rox1 are transcriptional repressors of hypoxic genes. Both factors recently have been found to be involved in the adaptive response to hyperosmotic stress, with an important function in the adjustment of ...

El exceso de sales en el medio causa grandes inconvenientes tanto a nivel agrícola debido a las pérdidas que se producen en la calidad y la cantidad de las cosechas, como a nivel médico, siendo responsable de un gran número ...

[EN] Here, we review and update the recent advances in the metabolic control during the adaptive response of budding yeast to hyperosmotic and salt stress, which is one of the best understood signaling events at the molecular ...

[EN] Stress triggers complex transcriptional responses, which include both gene activation and repression. We used time-resolved reporter assays in living yeast cells to gain insights into the coordination of positive and ...

Cells respond to environmental stimuli by fine-tuned regulation of gene expression. Here we investigated the dose-dependent modulation of gene expression at high temporal resolution in response to nutrient and stress signals ...

Mpc proteins are highly conserved from yeast to humans and are necessary for the uptake of pyruvate at the inner mitochondrial membrane, which is used for leucine and valine biosynthesis and as a fuel for respiration. Our ...

[EN] Optimized nutrient utilization is crucial for the progression of microorganisms in competing communities. Here we investigate how different budding yeast species and ecological isolates have established divergent ...

[EN] Cells respond to external stimuli with transient gene expression changes in order to adapt to environmental alterations. However, the dose response profile of gene induction upon a given stress depends on many intrinsic ...

En la presente tesis se han estudiado los distintos mecanismos de toxicidad de las micotoxinas citrinina y ocratoxina A y la respuesta adaptativa a xenobióticos en el modelo de levadura Saccharomyces cerevisiae, concretamente ...

[ES] El control de calidad de las mitocondrias es una función esencial de las células eucariotas. En los seres humanos, la falta de eliminación de las mitocondrias dañadas o disfuncionales es una causa de neurodegeneración. ...