Spronck, Bart; Latorre, Marcos; Wang, Mo; Mehta, Sameet; Caulk, Alexander W.; Ren, Pengwei; Ramachandra, Abhay B.; Murtada, Sae-Il; Rojas, Alexia; He, Chang-Shun; Jiang, Bo; Bersi, Matthew R.; Tellides, George; Humphrey, Jay D.(The Royal Society, 2021-07-28)
[EN] Hypertension induces significant aortic remodelling, often adaptive but sometimes not. To identify immuno-mechanical mechanisms responsible for differential remodelling, we studied thoracic aortas from 129S6/SvEvTac ...
Weiss, Dar; Cavinato, Cristina; Gray, Authia; Ramachandra, Abhay B.; Avril, Stephane; Humphrey, Jay D.; Latorre, Marcos(American Association for the Advancement of Science, 2020-12-04)
[EN] Arterial tortuosity manifests in many conditions, including hypertension, genetic mutations predisposing to thoracic aortopathy, and vascular aging. Despite evidence that tortuosity disrupts efficient blood flow and ...
Ramachandra, Abhay B.; Latorre, Marcos; Szafron, Jason M.; Marsden, Alison L.; Humphrey, Jay D.(Elsevier, 2020-10)
[EN] Vascular grafts have long been used to replace damaged or diseased vessels with considerable success, but a new approach is emerging where native vessels are merely supported, not replaced. Although external supports ...