[EN] Tissue engineering, including cell transplantation and the application of biomaterials and bioactive molecules, represents a promising approach for regeneration following spinal cord injury (SCI). We designed a ...
Cuenca-Ortolá, Irene; Martinez-Rojas, Beatriz; Moreno Manzano, Victoria; García Castelló, Marcos; Monleón Pradas, Manuel; Martínez-Ramos, Cristina; Más Estellés, Jorge(MDPI AG, 2022-11)
[EN] Neural progenitor cells (NPCs) have been shown to serve as an efficient therapeutic strategy in different cell therapy approaches, including spinal cord injury treatment. Despite the reported beneficial effects of NPC ...
Rodríguez Hernández, José Carlos(Universitat Politècnica de València, 2008-12-15)
El manuscrito versa sobre el desarrollo y caracterización de materiales híbridos basados en poliacrilato de hidroxietilo (a partir de ahora PHEA) reforzado por la inclusión de una fase amorfa de sílice. Ambas fases fueron ...
Sánchez-Martín, María del Mar; Giraldo-Reboloso, Esther; Gisbert-Roca, Fernando; Alastrue-Agudo, Ana; Martínez-Ramos, Cristina; Monleón Pradas, Manuel; Moreno-Manzano, Victoria(Frontiers Media SA, 2023-11-13)
[EN] Effective spinal cord injury (SCI) treatment remains a significant challenge, given the complex nature of the primary injury and associated devastating loss of neural activity. Neural progenitor cell (NPC)-based therapy ...
An experimental study was conducted to investigate the influence of ageing on the
morphological, thermal and mechanical properties of virgin and two types of recycled
(from technological and postconsumer wastes) modified ...
Jorge López, Francisco Javier(Universitat Politècnica de València, 2022-11-02)
[ES] El trabajo consiste en la simulación termohidráulica del sistema secundario de la central nuclear de Eslovenia ya que se va a proceder al cambio de la turbina principal de alta presión por una más moderna. El objetivo ...
Sancho Cortina, Carlos(Universitat Politècnica de València, 2021-07-06)
[ES] Es conocido que el rendimiento de Carnot es la máxima eficiencia teórica a la que puede aspirar un ciclo termodinámico. Este límite al rendimiento asume un ciclo reversible con dos procesos isotermos que transcurren ...
Roldán Herrero, Daniel(Universitat Politècnica de València, 2021-02-04)
[ES] En este trabajo de final de máster, se propone la realización de una revisión bibliográfica sobre los exosomas empleados en ingeniería tisular para la aplicación en lesiones del sistema nervioso central (SNC). En dicha ...
Zacares Pamblanco, Amparo; Monleón-Pradas, Mau(Universitat Politècnica de València, 2021-03-31)
[ES] El presente escrito se centra en el proyecto de arte público activista #PortalDeIgualdad, dirigido a la transformación de los museos y centros de arte, y que ha sido presentado en el contexto de Instituto Valenciano ...
[EN] The biological behaviour of Schwann cells (SCs) and dorsal root ganglia (DRG) on fibrillar, highly aligned and electroconductive substrates obtained by two different techniques is studied. Mats formed by nanometer-sized ...
Gisbert-Roca, Fernando; André, Franck M.; Más Estellés, Jorge; Monleón Pradas, Manuel; Mir, Lluis M.; Martínez-Ramos, Cristina(John Wiley & Sons, 2021-05)
[EN] The work here reported analyzes the effect of increased efficiency of brainderived neurotrophic factor (BDNF) production by electroporated Schwann cells (SCs) on the axonal extension in a coculture system on a biomaterial ...
Ivashchenko, Sergiy; Escobar Ivirico, Jorge Luis; García Cruz, Dunia Mercedes; Campillo Fernández, Alberto José; Gallego-Ferrer, Gloria; Monleón Pradas, Manuel(SAGE Publications, 2015)
[EN] A series of novel poly(CLMA-co-HEA)/silica nanocomposites is synthesized from caprolactone 2-(methacryloyloxy)ethyl ester (CLMA) and 2-hydroxyethyl acrylate (HEA) as organic comonomers and the simultaneous sol-gel ...
New biodegradable block copolymer networks were synthesized from methacrylate-terminated poly(L-lactide) (mLA) and polycaprolactone (mCL) macromers. This allowed the realization of a series of materials in which the macromer ...
Rodríguez Doblado, Laura(Universitat Politècnica de València, 2022-03-11)
[ES] Las lesiones del sistema nervioso que implican la interrupción de haces axonales son devastadoras para el individuo. La regeneración autónoma de los tractos axonales dañados o degenerados es poco frecuente, ya que ...
[EN] Spinal cord injuries (SCIs) result in the loss of sensory and motor function with massive cell death and axon degeneration. We have previously shown that transplantation of spinal cord-derived ependymal progenitor ...
[EN] Endogenous neurogenesis in stroke is insufficient to replace the lost brain tissue, largely due to the lack of a proper biological structure to let new cells dwell in the damaged area. We hypothesized that scaffolds ...
Soria, Jose Miguel; Sancho-Tello, María; Garcia Esparza, M. Angeles; Mirabet, Vicente; Bagan, Jose Vicente; Monleón Pradas, Manuel; Carda, Carmen(John Wiley & Sons, 2011)
[EN] This study is focused on the development of an in vitro hybrid system, consisting in a polymeric biomaterial covered by a dental pulp cellular stroma that acts as a scaffold offering a neurotrophic support for the ...
[EN] Repair of central nervous system (CNS) lesions is difficulted by the lack of ability of central axons to regrow, and the blocking by the brain astrocytes to axonal entry. We hypothesized that by using bridges made of ...