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Listar por autor "Botella Asuncion, Pablo"

Mostrando ítems 1-20 de 33

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AG5 is a potent non-steroidal anti-inflammatory and immune regulator that preserves innate immunity

BOTELLA ASUNCION, PABLO; Rivero-Buceta, Eva María; VIDAURRE AGUT, CARLA; Lama, Raquel; Rey-Campos, Magalí; Moreno, Alejandro; Mendoza, Laura; Mingo-Casas, Patricia; Escribano-Romero, Estela; Gutiérrez-Adán, Alfonso; Saiz, Juan Carlos; Smerdou, Cristian; Gonzalez, Gloria; Prósper, Felipe; Argemí, Josepmaría; San Miguel, Jesus; Sánchez Cordón, Pedro J.; Figueras, Antonio; Quesada-Gómez, Jose Manuel; Novoa, Beatriz; Montoya, María; Martín-Acebes, Miguel A.; Pineda-Lucena, Antonio; Benlloch Babiera, José María (Elsevier, 2023-11)

[EN] An archetypal anti-inflammatory compound against cytokine storm would inhibit it without suppressing the innate immune response. AG5, an anti-inflammatory compound, has been developed as synthetic derivative of ...
Amino modified metal-organic frameworks as pH-responsive nanoplatforms for safe delivery of camptothecin

Cabrera-García, Alejandro; Checa-Chavarria, Elisa; Rivero-Buceta, Eva María; MORENO MANZANO, VICTORIA; FERNANDEZ JOVER, EDUARDO; BOTELLA ASUNCION, PABLO (Elsevier, 2019-04-01)

[EN] MIL-100(Fe) and MIL-101(Fe) metal-organic frameworks (MOFs) are excellent vehicles for drug delivery systems (DDSs) due to their high biocompatibility and stability in physiological fluids, as well as their pore ...
DESARROLLO DE NUEVOS MATERIALES NANOESTRUCTURADOS BASADOS EN REDES ORGANOMETÁLICAS CON APLICACIONES BIOMÉDICAS

Cabrera García, Alejandro (Universitat Politècnica de València, 2019-04-01)

[ES] El desarrollo de nuevas metodologías para la detección y tratamiento del cáncer pasa por la necesidad de minimizar los efectos secundarios de las terapias actuales. En este campo, la nanotecnología permite diseñar y ...
Development of a Prodrug of Camptothecin for Enhanced Treatment of Glioblastoma Multiforme

Checa-Chavarria, Elisa; Rivero-Buceta, Eva María; Sanchez Martos, Miguel Angel; Martinez Navarrete, Gema; Soto-Sanchez, Cristina; BOTELLA ASUNCION, PABLO; FERNANDEZ JOVER, EDUARDO (American Chemical Society, 2021-04-05)

[EN] A novel therapeutic approach for glioblastoma multiforme (GBM) therapy has been carried out through in vitro and in vivo testing by using the prodrug camptothecin-20-O-(5-aminolevulinate) (CPT-ALA). The incorporation ...
Effect of surface properties in protein corona development on mesoporous silica nanoparticles

CLEMMENTS, ALDEN MICHAEL; Muniesa Lajara, Carlos; Landry, Christopher Caron; Botella Asuncion, Pablo (Royal Society of Chemistry, 2014)

[EN] The composition of the protein corona formed on mesoporous silica nanoparticles with several surface modifications was characterized. Low MW serum proteins were preferentially adsorbed, and PEGylated nanoparticles did ...
Engineered Contrast Agents in a Single Structure for T1-T2 Dual Magnetic Resonance Imaging

Cabrera-García, Alejandro; Checa-Chavarria, Elisa; Pacheco-Torres, Jesús; Bernabeu-Sanz, Angela; Vidal Moya, José Alejandro; Rivero-Buceta, Eva María; Sastre Navarro, German Ignacio; Fernandez Jover, Eduardo; Botella Asuncion, Pablo (The Royal Society of Chemistry, 2018-04-14)

[EN] The development of contrast agents (CAs) for Magnetic Resonance Imaging (MRI) with T-1-T-2 dual-mode relaxivity requires the accurate assembly of T-1 and T-2 magnetic centers in a single structure. In this context, ...
Estudio de la composición de la corona de proteínas sobre nanopartículas de sílice mesoporosa

Vidaurre Agut, Carla María (Universitat Politècnica de València, 2015-03-06)
Gd-Si Oxide Nanoparticles as Contrast Agents in Magnetic Resonance Imaging

Cabrera-García, Alejandro; Vidal Moya, José Alejandro; Bernabéu, Ángela; Pacheco Torres, Jesús; Checa Chavarría, Elisa; Fernández, Eduardo; Botella Asuncion, Pablo (MDPI, 2016-06)

[EN] We describe the synthesis, characterization and application as contrast agents in magnetic resonance imaging of a novel type of magnetic nanoparticle based on Gd-Si oxide, which presents high Gd3+ atom density. For ...
Glutathione-sensitive nanoplatform for monitored intracellular delivery and controlled release of Camptothecin

Muniesa Lajara, Carlos; Vicente Vilas, Victor; Quesada Vilar, Manuel; SAEZ-ATIENZAR, SARA; BLESA-BLESA, JOSE RAFAEL; Abasolo, Ibane; Fernández, Yolanda; Botella Asuncion, Pablo (Royal Society of Chemistry, 2013)

[EN] We report the design, synthesis, characterization and in vitro testing of a novel nanodrug based on a covalent linking model that allows intracellular controlled release of the pharmaceutical payload. A new synthetic ...
Hybrid PLGA-Organosilica Nanoparticles with Redox-Sensitive Molecular Gates

Quesada Vilar, Manuel; Muniesa Lajara, Carlos; Botella Asuncion, Pablo (American Chemical Society, 2013-07-09)

[EN] A novel type of hybrid material based on a PLGA nanoparticle core and a redox-responsive amorphous organosilica shell have been successfully synthesized. The outer layer is obtained by self-assembly of silicate ions ...
Intra-ocular lens optical changes resulting from the loading of dexamethasone

Artigas, Jose M.; Garcia-Domene, M. Carmen; Navea, Amparo; Botella Asuncion, Pablo; Fernandez, Eduardo (Optical Society of America, 2017)

[EN] To study the optical changes on hydrogel-silicone intraocular lenses (IOLs) resulting from loading them with dexamethasone. We used prototype hydrogel(pHEMA)silicone IOLs and loaded the matrices with an anti-inflammatory ...
Investigating the Influence of Au Nanoparticles on Porous SiO2-WO3 and WO3 Methanol Transformation Catalysts

DePuccio, Daniel P.; Ruiz-Rodríguez, Lidia; Rodriguez-Castellon, Enrique; Botella Asuncion, Pablo; López Nieto, José Manuel; Landry, Christopher C. (American Chemical Society, 2016-12-15)

Analyzing the structural and chemical properties of materials at the interface of metal nanoparticles and metal oxide supports is important for catalytic applications. Tungsten oxide (WO3) is a widely studied catalyst, but ...
Isolation and Quantification of miRNA from the Biomolecular Corona on Mesoporous Silica Nanoparticles

VIDAURRE AGUT, CARLA MARIA; Rivero-Buceta, Eva María; Landry, Christopher C.; BOTELLA ASUNCION, PABLO (MDPI AG, 2021-05)

[EN] To understand the factors that control the formation of the biomolecular corona, a systematic study of the adsorption of several miRNAs shown to be important in prostate cancer on amine-functionalized mesoporous silica ...
Light-activated controlled release of camptothecin by engineering porous materials: the ship in a bottle concept in drug delivery

Rivero-Buceta, Eva María; Encheva, Mirela E.; Cech, Bradley; Fernández, Eduardo; SASTRE NAVARRO, GERMAN IGNACIO; Landry, Christopher C.; BOTELLA ASUNCION, PABLO (The Royal Society of Chemistry, 2023-08-03)

[EN] Many systems for controlled drug release have been developed using different types of nanoparticles modified with azobenzene moieties. In these systems, drug release is often triggered by UV irradiation (either direct ...
Materiales nanoestructurados biocompatibles basados en sílice. Preparación y aplicaciones en terapia anticancerígena

Muniesa Lajara, Carlos (Universitat Politècnica de València, 2013-06-14)

El desarrollo de nanofármacos aplicados en terapias frente al cáncer es un prometedor campo de la biomedicina en el cual se entrecruzan diferentes disciplinas científicas como la biología, la ciencia de los materiales, ...
Mesoporous Silica and Oligo (Ethylene Glycol) Methacrylates-Based Dual-Responsive Hybrid Nanogels

Macchione, Micaela A.; Aristizábal Bedoya, Dariana; Rivero-Buceta, Eva María; BOTELLA ASUNCION, PABLO; Strumia, Miriam C. (MDPI AG, 2022-11)

[EN] Polymeric-inorganic hybrid nanomaterials have emerged as novel multifunctional platforms because they combine the intrinsic characteristics of both materials with unexpected properties that arise from synergistic ...
Mo-W-containing tetragonal tungsten bronzes through isomorphic substitution of molybdenum by tungsten

Botella Asuncion, Pablo; Solsona Espriu, Benjamin Eduardo; López Nieto, José Manuel; Concepción Heydorn, Patricia; Jorda Moret, Jose Luis; Domenech Carbo, Mª Teresa (Elsevier, 2010)

Mixed metal oxides based in Mo(W)–Nb–V–Te with tetragonal tungsten bronze (TTB) structure have been synthesized by a hydrothermal method from aqueous solutions of the corresponding Keggin-type heteropolyacids and further ...
Multifunctional hybrid materials for combined photo and chemotherapyof cancer

Botella Asuncion, Pablo; Ortega, Ilida; Quesada Vilar, Manuel; Madrigal Madrigal, Roque Fernando; Muniesa Lajara, Carlos; Fimia Gil, Antonio; Fernandez Jover, Eduardo; Corma Canós, Avelino (Royal Society of Chemistry, 2012)

[EN] Combined chemo and photothermal therapy in in vitro testing has been achieved by means of multifunctional nanoparticles formed by plasmonic gold nanoclusters with a protecting shell of porous silica that contains an ...
Nanomedicinas para terapia dirigida de glioblastoma multiforme

Alemany Ibor, Laura (Universitat Politècnica de València, 2021-07-30)

[ES] Glioblastoma multiforme (GBM) es el tumor cerebral más agresivo y letal conocido, con una media de supervivencia de 15 meses desde el diagnóstico inicial. Actualmente no existe un tratamiento farmacológico efectivo ...
Partial Oxidation of H(2)S to Sulfur Over Mo and/or W-Containing Bronzes with a TTB-Structure

Soriano Rodríguez, Mª Dolores; Concepción Heydorn, Patricia; Botella Asuncion, Pablo; López Nieto, José Manuel (Springer Verlag (Germany), 2011-07)

[EN] Mo- and W-based oxidic bronzes, with and without Te-atoms in framework positions are active and selective, for the partial oxidation of H2S to sulfur in the 160–220 C temperature range. The catalysts have been prepared ...