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Listar por autor "Cuquerella Alabort, Maria Consuelo"

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2'-Methoxyacetophenone as DNA photosensitiser for mono and biphotonic processes

Rodríguez Alzueta, Ofelia (Universitat Politècnica de València, 2021-01-17)

[ES] La luz solar es necesaria para la vida en la Tierra y sus efectos beneficiosos están fuera de toda duda. Sin embargo, la radiación ultravioleta (UV), que forma parte del espectro solar, puede resultar dañina para los ...
Benzophenone photosensitized DNA damage

Cuquerella Alabort, Maria Consuelo; Lhiaubet ., Virginie Lyria; Cadet, Jean; Miranda Alonso, Miguel Ángel (American Chemical Society, 2012)

[EN] A lthough the carcinogenic potential of ultraviolet radiation is well-known, UV light may interact with DNA by direct absorption or through photosensitization by endogenous or exogenous chromophores. These chromophores ...
Blocking cyclobutane pyrimidine dimer formation by steric hindrance

Vendrell Criado, Victoria; Lhiaubet, Virginie Lyria; Yamaji, Minoru; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel (Royal Society of Chemistry, 2016)

The efficiency of thymine (Thy) and uracil (Ura) to form cyclobutane pyrimidine dimers (CPDs) in solution, upon UV irradiation differs by one order of magnitude. This could to be partially related to the steric hindrance ...
Characterization of Locally Excited and Charge-Transfer States of the Anticancer Drug Lapatinib by Ultrafast Spectroscopy and Computational Studies

Vayá Pérez, Ignacio; Andreu Ros, María Inmaculada; Lence, Emilio; González-Bello, Concepción; Cuquerella Alabort, Maria Consuelo; Navarrete-Miguel, Miriam; Roca-Sanjuán, Daniel; Miranda Alonso, Miguel Ángel (John Wiley & Sons, 2020-12-04)

[EN] Lapatinib (LAP) is an anticancer drug, which is metabolized to theN- and O-dealkylated products (N-LAP andO-LAP, respectively). In view of the photosensitizing potential of related drugs, a complete experimental and ...
Drug-DNA complexation as the key factor in photosensitized thymine dimerization

Cuquerella Alabort, Maria Consuelo; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel; Bosca Mayans, Francisco (The Royal Society of Chemistry, 2017)

[EN] The crucial role of photosensitizer@DNA complexation in the formation of cyclobutane pyrimidine dimers (CPDs) has been demonstrated using femtosecond and nanosecond transient absorption and emission measurements in ...
Enantioselective intramolecular (2+2)-photocycloaddition reactions of 4-substituted quinolones catalyzed by a chiral sensitizer with a hydrogen-bonding motif

Müler, Christiane; Bauer, Andreas; Maturi, Mark M.; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel; Bach, Thorsten (American Chemical Society, 2011-09)

Six 2-quinolones, which bear a terminal alkene linked by a three- or four-membered tether to carbon atom C4 of the quinolone, were synthesized and subjected to an intramolecular [2 + 2]-photocycloaddition. The reaction ...
Estudio de quimioluminiscencia con aplicaciones anticancerígenos: Fotofísica y fotoquímica de luminol y derivados

Izquierdo Espinosa, Adrián (Universitat Politècnica de València, 2017-11-07)

[ES] La quimioluminiscencia es el fenómeno de emisión de luz al producirse una reacción química. Existen un gran número de aplicaciones de este fenómeno en campos tan diferentes como la tecnología, la criminalística o el ...
Formación de dímeros pirimidínicos en el estado excitado triplete: Ciclobutanos frente a fotoproductos (6,4)

Vendrell Criado, Victoria (Universitat Politècnica de València, 2015-12-09)

[EN] UV radiation is able to induce changes in the chemical composition of DNA that have been closely related to skin cancer. Among the most relevant lesions, damage to pyrimidine bases leading to bipyrimidine units ...
Generation of the Thymine Triplet State by Through-Bond Energy Transfer

Miró, Paula; Gomez-Mendoza, Miguel; SASTRE NAVARRO, GERMAN IGNACIO; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel; Marín García, Mª Luisa (John Wiley & Sons, 2019-05-17)

[EN] Benzophenone (BP) and drugs containing the BP chromophore, such as the non-steroidal anti-inflammatory drug ketoprofen, have been widely reported as DNA photo-sensitizers through triplet-triplet energy transfer (TTET). ...
Modulation by Phosphonium Ions of the Activity of Mitotropic Agents Based on the Chemiluminescence of Luminols

Rodríguez Muñiz, Gemma María; Mikroulis, Theodoros; Pantelia, Anna; Rotas, Georgios; Cuquerella Alabort, Maria Consuelo; Vougioukalakis, Georgios C.; Miranda Alonso, Miguel Ángel (MDPI AG, 2022-02)

[EN] Mitochondria-targeting drugs and diagnostics are used in the monitoring and treatment of mitochondrial pathologies. In this respect, a great number of functional compounds have been made mitotropic by covalently ...
Photocages for protection and controlled release of bioactive compounds

Aparici-Espert, Maria Isabel; Cuquerella Alabort, Maria Consuelo; Paris, Cecilia; Lhiaubet ., Virginie Lyria; Miranda Alonso, Miguel Ángel (The Royal Society of Chemistry, 2016)

[EN] Using a sunscreen-based photocage, we have demonstrated that it is possible to prevent photodegradation of a bioactive compound and to achieve its controlled photorelease. The concept has been proven linking avobenzone, ...
Photophysical properties of 5-substituted 2-thiopyrimidines

Vendrell Criado, Victoria; Sáez Cases, José Antonio; Lhiaubet, Virginie Lyria; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel (Royal Society of Chemistry, 2013)

The aim of the present work is to determine the influence of C5 substitution on the photophysical properties of 2-thiopyrimidines (2-TPyr). For this purpose, 2-thiouracil, 5-t-butyl-2-thiouracil and 2-thiothymine (TU, BTU ...
Photosensitised pyrimidine dimerisation in DNA

Bosca Mayans, Francisco; Lhiaubet, Virginie Lyria; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel (Royal Society of Chemistry, 2011)

Triplet-mediated pyrimidine (Pyr) dimerisation is a key process in photochemical damage to DNA. It may occur in the presence of a photosensitiser, provided that a number of requirements are fulfilled, such as favourable ...
Photosensitization of DNA by 5-methyl-2pyrimidone deoxyribonucleoside: (6-4) photoproduct as a posible trojan horse

Vendrell Criado, Victoria; Rodríguez Muñiz, Gemma María; Cuquerella Alabort, Maria Consuelo; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel (Wiley-VCH Verlag, 2013-06-17)

A (photo)sensitive subject: Combined agarose gel electrophoresis and photochemical studies show that 5-methyl-2-pyrimidone (see picture), the main chromophore of (6-4) photoproducts, behaves as a DNA photosensitizer. These ...
Protein binding of lapatinib and its N- and O-dealkylated metabolites interrogated by fluorescence, ultrafast spectroscopy and molecular dynamics simulations

Andreu Ros, María Inmaculada; Lence, Emilio; González-Bello, Concepción; Mayorga, Cristobalina; Cuquerella Alabort, Maria Consuelo; Vayá Pérez, Ignacio; Miranda Alonso, Miguel Ángel (Frontiers Media SA, 2020-10-30)

[EN] Lapatinib (LAP) is an anticancer drug generally used to treat breast and lung cancer. It exhibits hypersensitivity reactions in addition to dermatological adverse effects and photosensitivity. Moreover, LAP binds to ...
Seeking the mechanism responsible for fluoroquinolone photomutagenicity: a pulse radiolysis, steady-state, and laser flash photolysis study

Soldevila Serrano, Sonia; Cuquerella Alabort, Maria Consuelo; Lhiaubet-Vallet, Virginie; Edge, Ruth; Bosca Mayans, Francisco (Elsevier, 2014-02)

The mechanism responsible for the remarkable photomutagenicity of fluoroquinolone (FQ) antibiotics remains unknown. For this reason, it was considered worthwhile to study in detail the interactions between DNA and a ...
Synthesis and Chemiluminescent Properties of Amino-Acylated luminol Derivatives Bearing Phosphonium Cations

Pantelia, Anna; Daskalaki, Ira; Cuquerella Alabort, Maria Consuelo; Rotas, Georgios; Miranda Alonso, Miguel Ángel; Vougioukalakis, Georgios C. (MDPI AG, 2019-11)

[EN] The monitoring of reactive oxygen species in living cells provides valuable information on cell function and performance. Lately, the development of chemiluminescence-based reactive oxygen species monitoring has gained ...
The (6-4) Dimeric Lesion as a DNA Photosensitizer

Vendrell Criado, Victoria; Rodríguez Muñiz, Gemma María; Lhiaubet ., Virginie Lyria; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel (John Wiley & Sons, 2016)

[EN] Based on our previous investigations into the photophysical properties of the 5-methyl-2-pyrimidone (Pyo) chromophore, we now extend our studies to the photobehavior of the dimeric (6-4) thymine photoproducts (6-4 PP) ...
Transient UV-vis absorption spectroscopic characterisation of 2 '-methoxyacetophenone as a DNA photosensitiser

Rodriguez-Alzueta, Ofelia; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel (Elsevier, 2019-07-05)

[EN] 2'-Methoxyacetophenone (2M) presents improved UVA absorption as compared with other acetophenone derivatives. On the basis of transient infrared spectroscopy it has been previously claimed that 2M is an interesting ...
Triplet Energy Transfer versus Excited State Cyclization as the Controlling Step in Photosensitized Bipyrimidine Dimerization

Rodriguez-Alzueta, Ofelia; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel (American Chemical Society, 2019-11-01)

[EN] Polymethylene-linked bipyrimidine models have been designed with different C5 substitutions and bridge lengths. Selective irradiation of 2'-methoxyacetophenone (2M) with the bipyrimidine models affords cyclobutane ...