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Listar por autor "Martínez Mateu, Laura"

Mostrando ítems 1-20 de 23

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A Three-Dimensional Model of the Human Atria With Heterogeneous Wall Thickness and Fibre Transmurallity - A Realistic Platform for the Study of Atrial Fibrillation

Rocher-Ventura, Sara; Martínez, Laura; López, Alejandro; Ferrer, Ana; Sánchez-Quintana, Damián; Saiz Rodríguez, Francisco Javier (IEEE, 2019-09-11)

[EN] Multiscale cardiac modelling has been increasingly used since it provides a promising framework to improve our understanding of atrial fibrillation physiopathology. In this study, we present a highly detailed ...
Arrhythmogenic Effects of Genetic Mutations Affecting Potassium Channels in Human Atrial Fibrillation: A Simulation Study

Belletti, Rebecca; Romero Pérez, Lucia; Martínez-Mateu, Laura; Cherry, Elizabeth M.; Fenton, Flavio H.; Saiz Rodríguez, Francisco Javier (Frontiers Media SA, 2021-05-31)

[EN] Genetic mutations in genes encoding for potassium channel protein structures have been recently associated with episodes of atrial fibrillation in asymptomatic patients. The aim of this study is to investigate the ...
Arrhythmogenicity quantification of two genetic defects affecting IKr channel in AF patients

Belletti, R.; Martínez Mateu, L.; Romero Pérez, Lucia; Cherry, E.; Fenton, F. H.; Saiz Rodríguez, Francisco Javier (Sociedad Española de Ingeniería Biomédica, 2020-11-27)

[EN] Atrial fibrillation (AF) is the most common cardiac arrhythmia characterized by disorganized electrical activations of the upper chambers of the heart, leading to uncoordinated contraction and compromising the pumping ...
Atrial fibrosis identification with unipolar electrogram eigenvalue distribution analysis in multi-electrode arrays

Riccio, Jennifer; Alcaine, Alejandro; Rocher, Sara; Martínez-Mateu, Laura; Saiz Rodríguez, Francisco Javier; Invers-Rubio, Eric; Guillem Sánchez, María Salud; Martínez, Juan Pablo; Laguna, Pablo (Springer-Verlag, 2022-09-13)

[EN] Atrial fibrosis plays a key role in the initiation and progression of atrial fibrillation (AF). Atrial fibrosis is typically identified by a peak-to-peak amplitude of bipolar electrograms (b-EGMs) lower than 0.5 mV, ...
Atrial low voltage areas: A comparison between atrial fibrillation and sinus rhythm

Andrés Lahuerta, Ana; Roberto, Carlos; Saiz Rodríguez, Francisco Javier; Cano, Óscar; Martínez-Mateu, Laura; Alonso, Pau; Saurí, Assumpció; Quesada, Aurelio; Osca, Joaquín (VM Media Sp zo.o. - VMGroup SK, 2022)

[EN] Background: Atrial fibrosis can promote atrial fibrillation (AF). Electroanatomic mapping (EAM) can provide information regarding local voltage abnormalities that may be used as a surrogate marker for fibrosis. Specific ...
Blocking L-Type Calcium Current Reduces Vulnerability to Re-Entry in Human iPSC-Derived Cardiomyocytes Tissue

Dasi, Albert; Climent, Andreu M.; Martínez, Laura; Gómez, Juan F.; Ferrero De Loma-Osorio, José María; Trenor Gomis, Beatriz Ana (IEEE, 2019-09-11)

[EN] Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have proven to be crucial in pharmacological assessment. Nevertheless, their response to drugs when coupled forming a tissue is not fully understood. ...
Characterization of Atrial Propagation Patterns and Fibrotic Substrate With a Modified Omnipolar Electrogram Strategy in Multi-Electrode Arrays

Riccio, Jennifer; Alcaine, Alejandro; Rocher-Ventura, Sara; Martínez-Mateu, Laura; Laranjo, Sergio; Saiz Rodríguez, Francisco Javier; Laguna, Pablo; Martínez, Juan Pablo (Frontiers Media SA, 2021-09-03)

[EN] Introduction: The omnipolar electrogram method was recently proposed to try to generate orientation-independent electrograms. It estimates the electric field from the bipolar electrograms of a clique, under the ...
Computational simulations of the effects of the V17M missense mutation on atrial electrical activity

Belletti, Rebecca; Martínez Mateu, L.; Romero Pérez, Lucia; Saiz Rodríguez, Francisco Javier (Grupo de Técnicas Ópticas Aplicadas, Universidad de Cantabria, 2019-11-29)

[EN] Atrial fibrillation is a cardiac arrhythmia responsible for disorganized electrical activity of the upper chambers of the heart. Recently genetic mutations have been associated to episodes of atrial fibrillation in ...
Desarrollo de modelos ventriculares personalizados multiescala para pacientes pediátricos con arritmias ventriculares

Puente Alonso, María (Universitat Politècnica de València, 2021-02-24)

[ES] El presente Trabajo de Fin de Máster se enmarca en el ámbito del Modelado y Simulación Cardíaca, puesto que el principal objetivo es generar modelos 3D ventriculares personalizados para cada paciente de modo que se ...
Design, establishment, analysis and quality control of a high-precision reference frame in Cortes de Pallás (Spain)

García-Asenjo, Luis; Baselga, Sergio; Martínez, Laura; Garrigues, Pascual; Luján, Raquel (Editorial Universitat Politècnica de València, 2023-01-27)

[EN] A high-precision geodetic reference frame was required in Cortes de Pallás (Spain) to undertake a long-term deformation monitoring project. Involving distances up to 2000 m, the aimed accuracy was 1 mm and 3 mm for ...
Differential Modulation of I-K and I-Ca,I-L Channels in High-Fat Diet-Induced Obese Guinea Pig Atria

Martínez-Mateu, Laura; Saiz Rodríguez, Francisco Javier; Aromolaran, Ademuyiwa S. (Frontiers Media SA, 2019-09-25)

[EN] Obesity mechanisms that make atrial tissue vulnerable to arrhythmia are poorly understood. Voltage-dependent potassium (I-K, I-Kur, and I-K1) and L-type calcium currents (I-Ca,I- L) are electrically relevant and ...
Diseño y desarrollo de modelos personalizados multiescala de corazón completo para el estudio de la actividad eléctrica cardiaca

Milara Hernando, Eva (Universitat Politècnica de València, 2021-02-22)

[ES] Las enfermedades cardiovasculares son la principal causa de muerte en todo el mundo, especialmente las arritmias cardíacas y los trastornos de la conducción eléctrica. En la actualidad, el estudio de estas alteraciones ...
Diseño y desarrollo de una metodología para la creación de modelos personalizados anatómicos y electrofisiológicos de aurículas y torso humanos

Martínez Ulloa, Pablo (Universitat Politècnica de València, 2019-09-03)

[ES] Las enfermedades cardiovasculares son la primera causa de muerte en el mundo en los países desarrollados. Entre ellas, las arritmias supraventriculares tales como la taquicardia o fibrilación auriculares son muy ...
Diseño y desarrollo de una plataforma para la predicción de fibrilación auricular a partir del procesado de señales de ECG

Palomino Fernández, David (Universitat Politècnica de València, 2021-02-04)

[ES] La fibrilación auricular es una taquiarritmia supraventricular en la que las aurículas se activan de manera descoordinada sin contracción efectiva. Su presencia supone un aumento de riesgo de ictus y tromboembolismo ...
Estudio de métodos de procesado de señal para la caracterización de arritmias cardíacas en humanos mediante modelos computacionales

Martínez Mateu, Laura (Universitat Politècnica de València, 2014-03-03)

[ES] Las enfermedades cardiovasculares son una de las principales causas de mortalidad en el mundo. Entre ellas, las arritmias cardíacas se relacionan directamente con un aumento de la morbilidad y la mortalidad, siendo ...
Factors affecting basket catheter detection of real and phantom rotors in the atria: A computational study

Martínez-Mateu, Laura; Romero Pérez, Lucia; Ferrer Albero, Ana; Sebastián Aguilar, Rafael; Rodriguez Matas, José Félix; Jalife, José; Berenfeld, Omer; Saiz Rodríguez, Francisco Javier (Public Library of Science, 2018-03)

[EN] Anatomically based procedures to ablate atrial fibrillation (AF) are often successful in terminating paroxysmal AF. However, the ability to terminate persistent AF remains disappointing. New mechanistic approaches use ...
Far-field contributions in multi-electrodes atrial recordings blur distinction between anatomical and functional reentries and may cause imaginary phase singularities A computational study

Martínez-Mateu, Laura; Romero Pérez, Lucia; Saiz Rodríguez, Francisco Javier; Berenfeld, Omer (Elsevier, 2019)

[EN] Background Atrial fibrillation (AF) is the most common cardiac arrhythmia and the most important cause of embolic stroke, requiring new technologies for its better understanding and therapies. Recent approaches to ...
Heterogeneous effects of fibroblast-myocyte coupling in different regions of the human atria under conditions of atrial fibrillation

Sánchez Arciniegas, Jorge Patricio; Martínez Mateu, Laura; Gómez García, Juan Francisco; Romero Pérez, Lucia; Saiz Rodríguez, Francisco Javier; Trénor Gomis, Beatriz Ana (Universitat Politècnica de València, 2019-05-13)

[EN] Myofibroblasts differ from fibroblasts in that they develop contractile proteins and exhibit a more depolarized resting membrane potential (Salvarani et al., 2017) and greater membrane capacitance (Sridhar et al., ...
Mapping of the electrical activity of human atria. Multiscale modelling and simulations

Martínez Mateu, Laura (Universitat Politècnica de València, 2018-06-25)

La fibrilación auricular es una de las arritmias cardíacas más comunes observadas en la práctica clínica. Por lo tanto, es de vital importancia desarrollar nuevas tecnologías destinadas a diagnosticar y acabar con este ...
Non-invasive localization of atrial ectopic beats by using simulated body surface P-wave integral maps

Ferrer Albero, Ana; Godoy, Eduardo Jorge; Lozano, Miguel; Martínez Mateu, Laura; Alonso Atienza, Felipe; Saiz Rodríguez, Francisco Javier; Sebastián Aguilar, Rafael (Public Library of Science, 2017-07-13)

Non-invasive localization of continuous atrial ectopic beats remains a cornerstone for the treatment of atrial arrhythmias. The lack of accurate tools to guide electrophysiologists leads to an increase in the recurrence ...