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Listar por autor "Santiago Felipe, Sara"

Mostrando ítems 1-17 de 17

A fluorogenic capped mesoporous aptasensor for gluten detection

Pla, Luis; Martínez-Bisbal, M.Carmen; Aznar, Elena; Sancenón Galarza, Félix; Martínez-Máñez, Ramón; Santiago Felipe, Sara (Elsevier, 2021-02-22)

[EN] Celiac disease is a complex and autoimmune disorder caused by the ingestion of gluten affecting almost 1% of global population. Nowadays an effective treatment does not exist, and the only way to manage the disease ...
A gated material as immunosensor for in-tissue detection of IDH1-R132H mutation in gliomas

Pla, Luis; Sancenón Galarza, Félix; Martínez-Bisbal, M.Carmen; Prat-Acín, Ricardo; Galeano-Senabre, Inmaculada; Botello-Marabotto, Marina Dolores; Palanca-Suela, Sarai; Aznar, Elena; Santiago Felipe, Sara; Martínez-Máñez, Ramón (Elsevier, 2021-10-15)

[EN] A nanodevice consisted on nanoporous anodic alumina (NAA) supports functionalized with specific and selective antibody-based gatekeepers for the detection of IDH1-R132H mutant enzyme is here reported. Molecular profile ...
A new 8-oxo-7,8-2 ' deoxyguanosine nanoporous anodic alumina aptasensor for colorectal cancer diagnosis in blood and urine

Pla, Luis; Sancenón Galarza, Félix; Martínez-Bisbal, M.Carmen; Bañuls, Celia; Estañ, Nuria; Botello-Marabotto, Marina Dolores; Aznar, Elena; Sáez, Guillermo; Santiago-Felipe, Sara; Martínez-Máñez, Ramón (The Royal Society of Chemistry, 2021-05-14)

[EN] Many important human diseases, and especially cancer, have been related to the overproduction of 8-oxo-7,8-dihydro-2 '-deoxyguanosine (8-oxo-dG). This molecule is a product of oxidative stress processes over nucleophilic ...
Aptamer-Capped Nanoporous Anodic Alumina for SARS-CoV-2 Spike Protein Detection

Caballos-Gómez, María Isabel; Aranda, María Nieves; López-Palacios, Alba; Pla, Luis; Santiago Felipe, Sara; Hernández-Montoto, Andy; Tormo-Mas, María Ángeles; Pemán, Javier; Gómez-Ruiz, María Dolores; Calbuig, Eva; Sánchez-Sendra, Beatriz; Francés-Gómez, Clara; Geller, Ron; Aznar, Elena; Martínez-Máñez, Ramón (Wiley-VCH Verlag GmbH & Co. KGaA, 2023-06)

[EN] The COVID-19 pandemic, which began in 2019, has highlighted the importance of testing and tracking infected individuals as a means of mitigating the spread of the virus. In this context, the development of sensitive ...
Aptamer-Capped nanoporous anodic alumina for Staphylococcus aureus detection

Pla, Luis; Santiago Felipe, Sara; Tormo-Mas, María Ángeles; Pemán, Javier; Sancenón Galarza, Félix; Aznar, Elena; Martínez-Máñez, Ramón (Elsevier, 2020-10-01)

[EN] The development of new detection systems for an accurate and rapid identification of pathogens has become an essential challenge in the biomedical field. Herein a highly selective platform based on aptamer-gated nano ...
Comparison of DNA amplification methods for simultaneous detection of Salmonella spp. and Cronobacter sakazakii in milk

Santiago Felipe, Sara (Universitat Politècnica de València, 2016-02-04)

The control and detection of foodborne pathogens is a major problem in public health. Therefore, the development of rapid and economical diagnostic method along the food chain has become a priority. Among the available ...
Design of oligonucleotide-capped mesoporous silica nanoparticles for the detection of miRNA-145 by duplex and triplex formation

Ribes, Àngela; Santiago Felipe, Sara; Aviñó, Anna; Candela-Noguera, Vicente; Eritja, Ramón; Sancenón Galarza, Félix; Martínez-Máñez, Ramón; Aznar, Elena (Elsevier, 2018-12)

[EN] The development of new strategies to detect microRNAs (miRNAS) has become an important challenge in thebiomedical ¿eld. We report herein the use of oligonucleotide-gated silica nanoparticles for the detection ofmiRNA-145. ...
Integración de técnicas basadas en ADN para el desarrollo de biosensores aplicados en seguridad alimentaria

Santiago Felipe, Sara (Universitat Politècnica de València, 2015-10-26)

[EN] Food security is guaranteed when there is sufficient, safe and nutritious food. This assurance must be satisfied throughout the entire production process, which is known as "safety from farm to fork". This results in ...
Isothermal DNA amplification strategies for duplex microorganism detection

Santiago Felipe, Sara; Tortajada-Genaro, Luis Antonio; Morais, Sergi; Puchades, Rosa; Maquieira Catala, Ángel (Elsevier, 2015-05-01)

[EN] A valid solution for micro-analytical systems is the selection of a compatible amplification reaction with a simple, highly-integrated efficient design that allows the detection of multiple genomic targets. Two ...
Isothermal solid-phase recombinase polymerase amplification on microfluidic digital versatile discs (DVDs)

Tortajada-Genaro, Luis Antonio; Santiago Felipe, Sara; Amasia, Mary; Russom, Aman; Maquieira Catala, Ángel (Royal Society of Chemistry, 2015)

[EN] A new advancement in massive DNA-based screening in limited-resource settings is demonstrated through the incorporation of easy-to-fabricate microfluidic chambers on digital versatile discs (DVDs) to perform isothermal ...
Oligonucleotide-capped nanoporous anodic alumina biosensor as diagnostic tool for rapid and accurate detection of Candida auris in clinical samples

Pla, Luis; Santiago-Felipe, Sara; Tormo-Mas, María Ángeles; Ruiz-Gaitán, Alba; Peman, Javier; Valentín, Eulogio; Sancenón Galarza, Félix; Aznar, Elena; Martínez-Máñez, Ramón (Nature Publishing Group, 2021-01-01)

[EN] Candida auris has arisen as an important multidrug-resistant fungus because of several nosocomial outbreaks and elevated rates of mortality. Accurate and rapid diagnosis of C. auris is highly desired; nevertheless, ...
One-pot isothermal DNA amplification Hybridisation and detection by a disc-based method

Santiago Felipe, Sara; Tortajada-Genaro, Luis Antonio; Morais, Sergi; Puchades, Rosa; Maquieira Catala, Ángel (Elsevier, 2014-12-01)

[EN] An integrated sensor comprising isothermal DNA amplification and in situ detection is presented. The method principle is based on recombinase polymerase amplification (RPA) and detection in the microarray format by ...
Parallel solid-phase isothermal amplification and detection of multiple DNA targets in microliter-sized wells of a digital versatile disc

Santiago Felipe, Sara; Tortajada-Genaro, Luis Antonio; Puchades, Rosa; Maquieira Catala, Ángel (Springer Verlag (Germany), 2016-03)

An integrated method for the parallelized detection of multiple DNA target sequences is presented by using microstructures in a digital versatile disc (DVD). Samples and reagents were managed by using both the capillary ...
Real-time loop-mediated isothermal DNA amplification in compact disc micro-reactors

Santiago Felipe, Sara; Tortajada-Genaro, Luis Antonio; Carrascosa Rubio, Javier; Puchades, Rosa; Maquieira Catala, Ángel (Elsevier, 2016-05-15)

An integrated device composed of micro-reactors embedded onto compact discs is proposed for real-time targeted DNA determination. The method principle is based on in-disc loop-mediated isothermal amplification (iD-LAMP) ...
Recombinase polymerase and enzyme-linked immunosorbent assay as a DNA amplification-detection strategy for food analysis

Santiago Felipe, Sara; Tortajada-Genaro, Luis Antonio; Puchades, Rosa; Maquieira Catala, Ángel (Elsevier, 2014-02-06)

[EN] Polymerase chain reaction in conjunction with enzyme-linked immunosorbent assay (PCR-ELISA) is a well-established technique that provides a suitable rapid, sensitive, and selective method for a broad range of applications. ...
Triplex hybridization-based nanosystem for the rapid screening of pneumocystis pneumonia in clinical samples

Pla, Luis; Aviñó, Anna; Eritja, Ramón; Ruiz-Gaitán, Alba; Pemán, Javier; Friaza, Vicente; Calderón, Enrique J.; Aznar, Elena; Martínez-Máñez, Ramón; Santiago Felipe, Sara (MDPI, 2020-12)

[EN] Pneumocystis pneumonia (PcP) is a disease produced by the opportunistic infection of the fungus Pneumocystis jirovecii. As delayed or unsuitable treatments increase the risk of mortality, the development of rapid and ...
Two New Fluorogenic Aptasensors Based on Capped Mesoporous Silica Nanoparticles to Detect Ochratoxin A

Ribes, Àngela; Santiago Felipe, Sara; Bernardos Bau, Andrea; Marcos Martínez, María Dolores; Pardo Vicente, María Teresa; Sancenón Galarza, Félix; Martínez-Máñez, Ramón; Aznar, Elena (John Wiley & Sons, 2017)

[EN] Aptamers have been used as recognition elements for several molecules due to their great affinity and selectivity. Additionally, mesoporous nanomaterials have demonstrated great potential in sensing applications. Based ...