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Listar por autor "Lhiaubet, Virginie Lyria"

Mostrando ítems 1-20 de 52

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A Combined Experimental and Theoretical Approach to the Photogeneration of 5,6-Dihydropyrimidin-5-yl Radicals in Nonaqueous Media

Aparici-Espert, Maria Isabel; Francés Monerris, Antonio; Rodríguez Muñiz, Gemma María; Roca Sanjuan, Daniel; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel (American Chemical Society, 2016-05-20)

The chemical fate of radical intermediates is relevant to understand the biological effects of radiation and to explain formation of DNA lesions. A direct approach to selectively generate the putative reactive intermediates ...
A novel synthetic approach to tyrosine dimers based on pterin photosensitization

Reid, Lara O.; Castaño, Carolina; Dantola, M L.; Lhiaubet ., Virginie Lyria; Miranda Alonso, Miguel Ángel; Marín García, Mª Luisa; Thomas, A. H. (Elsevier, 2017)

[EN] Oxidative damage to proteins leads to a variety of modifications that are markers of pathogenesis. One of the most important modifications is the dityrosine (Tyr(2)) cross-link, resulting from an oxidative covalent ...
A photophysical approach to investigate the photooxidation mechanism of pesticides: Hydroxyl radical versus electron transfer

Marín García, Mª Luisa; Lhiaubet, Virginie Lyria; Santos-Juanes Jordá, Lucas; Soler Escoda, Juan Miguel; Gomis Vicens, Juan; Arques Sanz, Antonio; Amat Payá, Ana María; Miranda Alonso, Miguel Ángel (Elsevier, 2011-03-14)

[EN] The role of hydroxyl radical in different solar photocatalytic processes, namely photo-Fenton, titanium dioxide-based oxidation and organic photocatalysis (triphenylpyrylium) has been investigated. Using a methodology ...
A Sunscreen-Based Photocage for Carbonyl Groups

Lineros-Rosa, Mauricio; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria (John Wiley & Sons, 2020-06-05)

[EN] Photolabile protecting groups (PPGs) have been exploited in a wide range of chemical and biological applications, due to their ability to provide spatial and temporal control over light-triggered activation. In this ...
Benzophenone photosensitized DNA damage

Cuquerella Alabort, Maria Consuelo; Lhiaubet ., Virginie Lyria; Cadet, Jean; Miranda Alonso, Miguel Ángel (American Chemical Society, 2012)

[EN] A lthough the carcinogenic potential of ultraviolet radiation is well-known, UV light may interact with DNA by direct absorption or through photosensitization by endogenous or exogenous chromophores. These chromophores ...
Binding of naproxen enantiomers to human serum albumin studied by fluorescence and room-temperature phosphorescence

Lammers, Ivonne; Lhiaubet, Virginie Lyria; Freek, Ariese; Miranda Alonso, Miguel Ángel; Gooijer, Cees (Elsevier, 2013-03-15)

The interaction of the enantiomers of the non-steroidal anti-inflammatory drug naproxen (NPX) with human serum albumin (HSA) has been investigated using fluorescence and phosphorescence spectroscopy in the steady-state ...
Blocking cyclobutane pyrimidine dimer formation by steric hindrance

Vendrell Criado, Victoria; Lhiaubet, Virginie Lyria; Yamaji, Minoru; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel (Royal Society of Chemistry, 2016)

The efficiency of thymine (Thy) and uracil (Ura) to form cyclobutane pyrimidine dimers (CPDs) in solution, upon UV irradiation differs by one order of magnitude. This could to be partially related to the steric hindrance ...
Chemical Modifications of Globular Proteins Phototriggered by an Endogenous Photosensitizer

Reid, Lara O.; Dántola, M. Laura; Petroselli, Gabriela; Erra-Balsells, Rosa; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria; Thomas, Andrés H. (American Chemical Society, 2019-11)

[EN] The main goal of the present work was to investigate the damages photoinduced by pterin (Ptr), an endogenous photosensitizer present in human skin under pathological conditions, on a globular protein such as ubiquitin ...
Drug-DNA complexation as the key factor in photosensitized thymine dimerization

Cuquerella Alabort, Maria Consuelo; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel; Bosca Mayans, Francisco (The Royal Society of Chemistry, 2017)

[EN] The crucial role of photosensitizer@DNA complexation in the formation of cyclobutane pyrimidine dimers (CPDs) has been demonstrated using femtosecond and nanosecond transient absorption and emission measurements in ...
El papel de los metabolitos en la fototoxicidad de filtros solares

Garcia Castellanos, Marina (Universitat Politècnica de València, 2023-09-25)

[ES] El uso de los filtros ultravioleta (UV) se ha extendido en la actualidad para millones de personas. Sin embargo, algunos de ellos no son biodegradables en su totalidad y las plantas de tratamiento de aguas residuales ...
Enhanced Drug Photosafety by Interchromophoric Interaction Due to Intramolecular Charge Separation

Li, Ming-De; Yan, Zhiping; Zhu, Ruixue; Phillips,David Lee; Aparici-Espert, Maria Isabel; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel (John Wiley & Sons, 2018-05-02)

[EN] Imatinib is a synthetic tyrosinase inhibitor that is employed for the treatment of some kinds of human cancer. This drug has a low phototoxicity towards DNA, but its pyridylpyrimidine (1) fragment by itself exhibits ...
Enhanced photochemical [6pi] electrocyclization within the lipophilic protein binding site

Marín Melchor, Mireia; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel (American Chemical Society, 2012)

Photocyclization of N-methyldiphenylamine to N-methylcarbazole is achieved within the microenvironment provided by site I of serum albumins. Quantum yield determinations, combined with transient absorption spectroscopic ...
Experimental and theoretical studies on thymine photodimerization mediated by oxidatively generated DNA lesions and epigenetic intermediates

Lineros-Rosa, Mauricio; Francés-Monerris, Antonio; Monari, Antonio; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria (The Royal Society of Chemistry, 2020-11-28)

[EN] Interaction of nucleic acids with light is a scientific question of paramount relevance not only in the understanding of life functioning and evolution, but also in the insurgence of diseases such as malignant skin ...
Experimental and Theoretical Study on the Cycloreversion of a Nucleobase-Derived Azetidine by Photoinduced Electron Transfer

Fraga-Timiraos, Ana Belén; Francés-Monerris, Antonio; Rodríguez Muñiz, Gemma María; Navarrete-Miguel, Miriam; Miranda Alonso, Miguel Ángel; Roca Sanjuan, Daniel; Lhiaubet, Virginie Lyria (John Wiley & Sons, 2018-10-12)

[EN] Azetidines are interesting compounds in medicine and chemistry as bioactive scaffolds and synthetic intermediates. However, photochemical processes involved in the generation and fate of azetidine-derived radical ions ...
Fotorreparación de lesiones del ADN por sistemas modelo

Piñero Piquer, Enrique (Universitat Politècnica de València, 2022-07-18)

[ES] La peroxidación lipídica es un proceso biológico que ocurre ininterrumpidamenteen nuestro cuerpo como resultado de la oxidación de la membrana celular por especies reactivas de oxígeno (EROs). La degradación de los ...
Generation of reactive aryl radical intermediates in the reductive photodehalogenation of itraconazole

Nardi, Giacomo; Marín García, Mª Luisa; de Souza, Pierre A.; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel (The Royal Society of Chemistry, 2014)

[EN] The photochemical properties of itraconazole (1), a broad-spectrum antifungal agent, have been investigated in connection with reported skin photosensitivity disorders. Steady state photolysis, fluorescence and ...
MECHANISTIC STUDIES ON THE PHOTOTOXICITY OF ROSUVASTATIN, ITRACONAZOLE AND IMATINIB

Nardi, Giacomo (Universitat Politècnica de València, 2015-03-31)

Photosensitizing effects of xenobiotics are of increasing concern in public health since modern lifestyle often associates sunlight exposure with the presence of chemical substances in the skin. An important number of ...
Model Studies on the Photoreduction of the 5-Hydroxy-5,6-dihydrothymine and 5-Methyl-2-pyrimidone Moieties of (6-4) Photoproducts by Photolyase

Rodríguez Muñiz, Gemma María; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria (Blackwell Publishing, 2022-01-17)

[EN] Photorepair mechanism of (6-4) photoproducts (6-4PP) by photolyase has been the subject of active debate over the years. The initial rationalization based on electron transfer to an oxetane or azetidine intermediate ...
Model Studies on the Photorepair of (6-4) Dimeric Lesions of DNA

Fraga Timiraos, Ana Belén (Universitat Politècnica de València, 2019-03-04)

[ES] La radiación ultravioleta está asociada a la formación de ciertas lesiones en el ADN que están en el origen del cáncer de piel. Entre las más relevantes se encuentran los daños que se producen en las bases pirimidínicas: ...
Novel Oxybenzone Photolabile Protecting Group for Carbonyl Compounds

Fernández, Benjamín Matthew (Universitat Politècnica de València, 2021-10-29)

[ES] Se está estudiando una nueva clase de grupo protector fotolábil (PPG) basada en el uso de filtro solares. Los PPG son unidades químicas que permiten la protección de grupos funcionales y su posterior fotoliberación. ...