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Listar por autor "Andreu Ros, María Inmaculada"

Mostrando ítems 1-20 de 62

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"Snorkelling" vs. "diving" in mixed micelles probed by means of a molecular bathymeter

Rodríguez Muñiz, Gemma María; Gomez Mendoza, Miguel; Nuin Pla, Neus Edurne; Andreu Ros, María Inmaculada; Marín García, Mª Luisa; Miranda Alonso, Miguel Ángel (The Royal Society of Chemistry, 2017)

[EN] A photoactive bathymeter based on a carboxylic acid moiety covalently linked to a signalling methoxynaphthalene (MNP) fluorophore has been designed to prove the concept of "snorkelling" vs. "diving" in mixed micelles ...
A Look at the Importance of Chirality in Drug Activity: Some Significative Examples

Ceramella, Jessica; Iacopetta, Domenico; Franchini, Angelica; De Luca, Michele; Saturnino, Carmela; Andreu, Inmaculada; Sinicropi, Maria Stefania; Catalano, Alessia (MDPI AG, 2022-11)

[EN] Chirality plays an important role in the development of many pharmaceuticals, being a general property of 'handedness'; nevertheless, a large number of pharmaceuticals are still marketed and administered as racemates. ...
A New Pathway for Protein Haptenation by beta-Lactams

Pérez-Ruiz, Raúl; Lence, Emilio; Andreu Ros, María Inmaculada; Limones Herrero, Daniel; González-Bello, Concepción; Miranda Alonso, Miguel Ángel; Jiménez Molero, María Consuelo (John Wiley & Sons, 2017-10-09)

[EN] The covalent binding of beta-lactams to proteins upon photochemical activation has been demonstrated by using an integrated approach that combines photochemical, proteomic and computational studies, selecting human ...
Allergic Reactions to Metamizole: Immediate and Delayed Responses

Blanca-López, Natalia; Pérez-Sanchez, Natalia; Agúndez, Jose A.G.; García-Martín, Elena; Torres, Maria José; Cornejo-Garcia, José Antonio; Perkins, James R.; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada; Mayorga, Cristobalina; Canto, María Gabriela; Blanca, Miguel; Doña, Inmaculada (S. Karger AG, 2016)

[EN] Background: Pyrazolones are the most common causes of selective nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity. We studied a large group of patients with immediate and delayed selective responses to ...
Assessment of drug entrapment within liposomes using photophysical probes

Oliverio, Filomena; Nuin Plá, Neus Edurne; Andreu Ros, María Inmaculada; Ragno, Gaetano; Miranda Alonso, Miguel Ángel (Elsevier, 2014-10)

The photophysical and photochemical behavior of (R)-cinacalcet (CIN) and (S)-naproxen (NPX) entrapped within liposomes has been studied. For this purpose, liposome encapsulated drugs have been prepared through thin layer ...
Assessment of the PARP inhibitor talazoparib photosafety profile

Mateos-Pujante, Alejandro; Jiménez, M Consuelo; Andreu, Inmaculada (Elsevier, 2023-11)

[EN] Talazoparib (TLZ) is a poly(adenosine diphosphate [ADP]-ribose) polymerase inhibitor employed for the treatment of breast cancer. This drug displays an absorption band in the UVA region, and therefore investigation ...
Biradical vs singlet oxygen photogeneration in suprofen cholesterol systems

Palumbo, Fabrizio; Bosca Mayans, Francisco; Morera Bertomeu, Isabel María; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel (Beilstein-Institut, 2016-06-14)

Cholesterol (Ch) is an important lipidic building block and a target for oxidative degradation, which can be induced via free radicals or singlet oxygen (1O2). Suprofen (SP) is a nonsteroidal anti-inflammatory drug that ...
Cellular photo(geno)toxicity of gefitinib after biotransformation

El Ouardi, Meryem; Tamarit-Mayo, Lorena; Vayá Pérez, Ignacio; Miranda, Miguel A.; Andreu, Inmaculada (Frontiers Media SA, 2023-06-07)

[EN] Gefitinib (GFT) is a selective epidermal growth factor receptor (EGFR) inhibitor clinically used for the treatment of patients with non-small cell lung cancer. Bioactivation by mainly Phase I hepatic metabolism leads ...
Characterization of Locally Excited and Charge-Transfer States of the Anticancer Drug Lapatinib by Ultrafast Spectroscopy and Computational Studies

Vayá Pérez, Ignacio; Andreu Ros, María Inmaculada; Lence, Emilio; González-Bello, Concepción; Cuquerella Alabort, Maria Consuelo; Navarrete-Miguel, Miriam; Roca-Sanjuán, Daniel; Miranda Alonso, Miguel Ángel (John Wiley & Sons, 2020-12-04)

[EN] Lapatinib (LAP) is an anticancer drug, which is metabolized to theN- and O-dealkylated products (N-LAP andO-LAP, respectively). In view of the photosensitizing potential of related drugs, a complete experimental and ...
Chemical tuning for potential antitumor fluoroquinolones

Anaya-González, Cristina; Soldevila Serrano, Sonia; García-Laínez, Guillermo; Bosca Mayans, Francisco; Andreu Ros, María Inmaculada (Elsevier, 2019-09)

[EN] Phototoxic effects of 6,8 dihalogenated quinolones confers to this type of molecules a potential property as photochemotherapeutic agents. Two photodehalogenation processes seem to be involved in the remarkable ...
Clinical Characterization and Diagnostic Approaches for Patients Reporting Hypersensitivity Reactions to Quinolones

Doña, Inmaculada; Pérez-Sánchez, Natalia; Salas, María; Barrionuevo, Esther; Ruiz-San Francisco, Arturo; Hernández Fernández de Rojas, Dolores; Martí-Garrido, Jaume; Andreu Ros, María Inmaculada; López-Salgueiro, Ramón; Moreno, Esther; Torres, María José (Elsevier, 2020-09)

[EN] BACKGROUND: Quinolones are the second most frequent cause of hypersensitivity reactions (HSRs) to antibiotics. A marked increase in the number of patients with HSRs to quinolones has been detected. OBJECTIVE: To ...
Configuration-dependent photoinduced electron transfer in diastereomeric naphthalene-amino-naphthalene triads

Nuin Pla, Neus Edurne; Sastre Navarro, German Ignacio; Pischel, Uwe; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel (John Wiley & Sons, 2015)

[EN] Novel diastereomeric triads containing two naphthalene chromophores have been designed in which an electron-donating amine moiety is covalently integrated into the connecting bridge. Photophysical studies (steady-state ...
Cytotoxic sub-nanometer aqueous platinum clusters as potential antitumoral agents

Greco, Rossella; García-Laínez, Guillermo; Oliver-Meseguer, Judit; Marini, Carlo; Domínguez, Irene; Lopez-Haro, Miguel; Hernandez-Garrido, Juan Carlos; Cerón-Carrasco, José Pedro; Andreu, Inmaculada; Leyva Perez, Antonio (Royal Society of Chemistry, 2022-12-06)

[EN] Ligand-free sub-nanometer metal clusters (MCs) of Pt, Ir, Rh, Au and Cu, are prepared here in neat water and used as extremely active (nM) antitumoral agents for HeLa and A2870 cells. The preparation just consists of ...
Diarylureas: New Promising Small Molecules against Streptococcus mutans for the Treatment of Dental Caries

Iacopetta, Domenico; Ceramella, Jessica; Catalano, Alessia; D'amato, Assunta; Lauria, Graziantonio; Saturnino, Carmela; Andreu, Inmaculada; Longo, Pasquale; Sinicropi, Maria Stefania (MDPI AG, 2023-01)

[EN] Dental caries is a biofilm-mediated disease that represents a worldwide oral health issue. Streptococcus mutans has been ascertained as the main cariogenic pathogen responsible for human dental caries, with a high ...
Drug-drug interactions within protein cavities probed by triplet-triplet energy transfer

Nuin Plá, Neus Edurne; Jiménez Molero, María Consuelo; Sastre Navarro, German Ignacio; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel (American Chemical Society, 2013-05-16)

A new direct and noninvasive methodology based on transient absorption spectroscopy has been developed to probe the feasibility of drug-drug interactions within a common protein binding site. The simultaneous presence of ...
Drugs for COVID-19: An Update

Ceramella, Jessica; Iacopetta, Domenico; Sinicropi, Maria Stefania; Andreu, Inmaculada; Mariconda, Annaluisa; Saturnino, Carmela; Giuzio, Federica; Longo, Pasquale; Aquaro, Stefano; Catalano, Alessia (MDPI AG, 2022-12)

[EN] The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was the seventh known human coronavirus, and it was identified in Wuhan, Hubei province, China, in 2020. It caused the highly contagious disease called ...
Enhanced photo(geno)toxicity of demethylated chlorpromazine metabolites

Palumbo, Fabrizio; García Lainez, Guillermo; Limones Herrero, Daniel; Coloma, María Dolores; Escobar, Javier; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada (Elsevier, 2016)

Chlorpromazine (CPZ) is an anti-psychotic drug widely used to treat disorders such as schizophrenia or manic-depression. Unfortunately, CPZ exhibits undesirable side effects such as phototoxic and photoallergic reactions ...
Enhanced photosafety of cinacalcet upon complexation with serum albumin

Nuin Plá, Neus Edurne; Andreu Ros, María Inmaculada; Torres, Maria Jose; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel (American Chemical Society, 2011-02-10)

Cinacalcet (CIN) is a calcimimetic drug, which contains a naphthalene chromophore and binds almost quantitatively to human serum albumin (HSA). In the present work, the excited states of CIN have been characterized in order ...
Estudio de la foto(geno)toxicidad del diclofenaco y sus metabolitos

Martínez Reig, Ana María (Universitat Politècnica de València, 2017-08-30)

The diclofenac is a drug widely used for relieving mild to moderate pain that can be used in tablet forms as well as in gel for topical treatment. Exposure to sunlight after diclofenac administration is associated with an ...
Estudio de las reacciones radicalarias del colesterol en diadas modelo

Palumbo, Fabrizio (Universitat Politècnica de València, 2014-11-28)

[EN] Cholesterol (Ch) is one of the most important building blocks of cell membranes. It is also one of the main targets for oxidation via Type I hydrogen abstraction (HA), which leads to a variety of physiological ...