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Listar por autor "Vayá Pérez, Ignacio"

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A joint experimental/theoretical study of the ultrafast excited state deactivation of deoxyadenosine and 9-methyladenine in water and acetonitrile

Gustavsson, Thomas; Sarkar, Nilmoni; Vayá Pérez, Ignacio; Jiménez Molero, María Consuelo; Markovitsi, Dimitra; Improta, Roberto (Royal Society of Chemistry, 2013)

The excited states of deoxyadenosine (dA) and 9-methyladenine (9Me-Ade) were studied in water and acetonitrile by a combination of steady-state and time-resolved spectroscopy and quantum chemical calculations. Femtosecond ...
Arylisoquinoline-derived organoboron dyes with a triaryl skeleton show dual fluorescence

Pais, Vania F.; Neumann, T.; Vayá Pérez, Ignacio; Jiménez Molero, María Consuelo; Ros, Abel; Pischel, Uwe (Beilstein-Institut, 2019-11-04)

[EN] Four new dyes that derive from borylated arylisoquinolines were prepared, containing a third aryl residue (naphthyl, 4-methoxynaphthyl, pyrenyl or anthryl) that is linked via an additional stereogenic axis. The triaryl ...
Base Pairing Enhances Fluorescence and Favors Cyclobutane Dimer Formation Induced upon Absorption of UVA Radiation by DNA

Banyasz, Akos; Vayá Pérez, Ignacio; Changenet-Barret, Pascale; Gustavsson, Thomas; Douki, Thierry; Markovitsi, Dimitra (American Chemical Society, 2011-03-18)

[EN] The photochemical properties of the DNA duplex (dA)(20) center dot (dT)(20) are compared with those of the parent single strands. It is shown that base pairing increases the probability of absorbing UVA photons, ...
Cellular photo(geno)toxicity of gefitinib after biotransformation

El Ouardi, Meryem; Tamarit-Mayo, Lorena; Vayá Pérez, Ignacio; Miranda, Miguel A.; Andreu, Inmaculada (Frontiers Media SA, 2023-06-07)

[EN] Gefitinib (GFT) is a selective epidermal growth factor receptor (EGFR) inhibitor clinically used for the treatment of patients with non-small cell lung cancer. Bioactivation by mainly Phase I hepatic metabolism leads ...
Characterization of Locally Excited and Charge-Transfer States of the Anticancer Drug Lapatinib by Ultrafast Spectroscopy and Computational Studies

Vayá Pérez, Ignacio; Andreu Ros, María Inmaculada; Lence, Emilio; González-Bello, Concepción; Cuquerella Alabort, Maria Consuelo; Navarrete-Miguel, Miriam; Roca-Sanjuán, Daniel; Miranda Alonso, Miguel Ángel (John Wiley & Sons, 2020-12-04)

[EN] Lapatinib (LAP) is an anticancer drug, which is metabolized to theN- and O-dealkylated products (N-LAP andO-LAP, respectively). In view of the photosensitizing potential of related drugs, a complete experimental and ...
Characterization of the lowest singlet and triplet states of S-Flurbiprofen

Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel; Tormos Faus, Rosa Esperanza; Vayá Pérez, Ignacio (The Royal Society of Chemistry, 2004)

[EN] The photophysical properties of S-flurbiprofen [S-2-fluoro-alpha-methyl-4-biphenylacetic acid], a nonsteroidal anti-inflammatory drug, have been examined using steady-state and time-resolved spectroscopic techniques. ...
Determination of enantiomeric compositions by transient absorption spectroscopy using proteins as chiral selectors

Vayá Pérez, Ignacio; Bueno Alejo, Carlos Javier; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel (John Wiley & Sons, 2008)
Diastereodifferentiation of novel naphthalene dyads by fluorescence quenching and excimer formation

Abad Fuentes, Sergio; Vayá Pérez, Ignacio; Jiménez Molero, María Consuelo; Pischel ., Uwe; Miranda Alonso, Miguel Ángel (John Wiley & Sons, 2006)

[EN] Four new bichromophoric naphthalene dyads in form of diastereomeric pairs are synthesized and photophysically characterized. For a closely related group of compounds (NAP-NAP MNAP-NAP, MNAP-MNAP), systematic variation ...
Diseño de nanopartículas de oro funcionalizadas con AINEs y proteínas para su uso en biomedicina

Tamarit Mayo, Lorena (Universitat Politècnica de València, 2018-10-11)

[ES] En este trabajo se han diseñado una serie de nanopartículas de oro (AuNPs) esféricas funcionalizadas con fármacos (antiinflamatorios no esteroideos, AINEs) con la finalidad de realizar un estudio fotofísico completo ...
Diseño de nanorods de oro con fármacos fotoactivos para estudios de citotoxicidad celular

Palomares Ferrando, Adrià (Universitat Politècnica de València, 2021-10-06)

[ES] Este proyecto se ha centrado en el diseño y estudio de las propiedades de nanorods de oro para su posible aplicación en terapia fototérmica (PTT), para el tratamiento de ciertos tipos de cánceres. La terapia fototérmica ...
Drug/protein interactions studied by time-resolved fluorescence spectroscopy

Gustavsson, Thomas; Markovitsi, Dimitra; Vayá Pérez, Ignacio; Bonancía Roca, Paula; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel (Society of Photo-optical Instrumentation Engineers (SPIE), 2014)

[EN] We report here on a recent time-resolved fluorescence study [1] of the interaction between flurbiprofen (FBP), a chiral non-steroidal anti-inflammatory drug, and human serum albumin (HSA), the main transport protein ...
Electronic Excitation Energy Transfer between Nucleobases of Natural DNA

Vayá Pérez, Ignacio; Gustavsson, Thomas; Douki, Thierry; Berlin, Yuri; Markovitsi, Dimitra (American Chemical Society, 2012-07-18)

[EN] Transfer of the electronic excitation energy in calf thymus DNA is studied by time-resolved fluorescence spectroscopy. The fluorescence anisotropy, after an initial decay starting on the femtosecond time scale, dwindles ...
Electronic excited states of guanine-cytosine hairpins and duplexes studied by fluorescence spectroscopy

Brazard, J.; Thazhathveetil, A.K.; Vayá Pérez, Ignacio; Lewis, F.D.; Gustavsson, T.; Markovitsi, D. (Royal Society of Chemistry, 2013)

[EN] Guanine-cytosine hairpins, containing a hexaethylene glycol bridge, are studied by steady-state fluorescence spectroscopy and time-correlated single photon counting; their properties are compared to those of duplexes ...
Electronic Excited States Responsible for Dimer Formation upon UV Absorption Directly by Thymine Strands: Joint Experimental and Theoretical Study

Banyasz, Akos; Douki, Thierry; Improta, Roberto; Gustavsson, Thomas; Onidas, Delphine; Vayá Pérez, Ignacio; Perron, Marion; Markovitsi, Dimitra (American Chemical Society, 2012-09-12)

[EN] The study addresses interconnected issues related to two major types of cycloadditions between adjacent thymines in DNA leading to cyclobutane dimers (T <> Ts) and (6-4) adducts. Experimental results are obtained for ...
Electronically excited states of DNA oligonucleotides with disordered base sequences studied by fluorescence spectroscopy

Vayá Pérez, Ignacio; Brazard, J.; Gustavsson, T.; Markovitsi, D. (Royal Society of Chemistry, 2012)

[EN] DNA double-stranded oligomers are studied by steady-state and time-resolved fluorescence spectroscopy from the femtosecond to the nanosecond time-scale, following excitation at 267 nm. It is shown that emission arises ...
Estados excitados del antiinflamatorio no esteroideo flurbiprofeno como sondas para la interacción con proteínas

Vayá Pérez, Ignacio (Universitat Politècnica de València, 2008-05-07)

Las proteínas son macromoléculas muy abundantes en los organismos vivos. En concreto, la importancia de las proteínas transportadoras (como albúmina sérica humana y bovina) radica en que actúan como vehículo para la ...
Estudio de la fotorreactividad de sistemas naproxeno-amino ácido en espacios confinados

Verdasco Vivancos, Antonio (Universitat Politècnica de València, 2020-05-05)

[ES] En este trabajo se han estudiado las propiedades fotofísicas del antiinflamatorio no esteroideo naproxeno en diferentes entornos cuyo grado de complejidad va aumentando progresivamente. Los diferentes modelos diseñados ...
Estudio fotofisico y fotoquímico de diadas flurbiprofeno-triptófano como modelos sencillos de sistemas fármaco-proteína

García Gabarda, Laura (Universitat Politècnica de València, 2022-10-27)

[ES] En este trabajo de fin de grado se ha sintetizado una serie de sistemas bicromofóricos (o diadas) compuestos por el flurbiprofeno (FBP), un fármaco antiinflamatorio utilizado para el tratamiento de diversas dolencias, ...
Estudio fotofísico de sistemas bicromofóricos conteniendo flurbiprofeno y tirosina

Rondón Sarmiento, Yameiri (Universitat Politècnica de València, 2016-01-13)
Estudio fotoquímico y fotofísico del fármaco Sulindaco y sus metabolitos en medios biológicos

Calero Pons, Elena (Universitat Politècnica de València, 2019-09-04)

[ES] En este trabajo se ha estudiado la fotorreactividad del fármaco sulindaco (SLD), que es un antiinflamatorio no esteroideo (AINE), en disolución y en presencia de proteínas. También se ha investigado la fotorreactividad ...