[EN] Background. Angiogenesis and lymphangiogenesis are key mechanisms for tumor growth and dissemination. They are mainly regulated by the vascular endothelial growth factor (VEGF) family of ligands and receptors. The aim ...
[EN] Tumors develop mechanisms to recruit tolerogenic immune cells and to induce the expression of molecules that act as immune checkpoints. This regulation of the immune microenvironment favors immune tolerance to the ...
[EN] Background: Epidermal growth factor receptor (EGFR) is overexpressed in a variety of epithelial malignancies including lung cancer. A soluble fragment of the EGFR extracellular domain (sEGFR) can be detected in the ...
Camps, Carlos; Dirección General de Agricultura, Minas y Montes(Real Sociedad Económica de Amigos del País de Valencia, 1918-06-25)
Circular remitida por D. Carlos Camps, Director General de Agricultura, Minas y Montes, comunicando al Presidente de la Económica tenga a bien enviarle los Estatutos de las Asociaciones Agrícolas existentes en la Provincia, ...
Sirera Pérez, Rafael; Bremnes, Roy M.; Cabrera, Andrea; Jantus Lewintre, Eloisa; Sanmartin, Elena; Blasco, Ana; del Pozo, Nieves; Rosell, Rafael; Guijarro, Ricardo; Galbis, Jose; Sanchez, Jose Javier; Camps, Carlos(Lippincott, Williams & Wilkins, 2011-02)
Background: Circulating DNA is observed at higher concentrations in patients with lung cancer than in controls. Qualitative and quantitative analysis of circulating DNA is a promising noninvasive tool. Our aim was to ...
Introduction: The vascular endothelial growth factor (VEGF) family of ligands and receptors (VEGFR) play an important role in tumor angiogenesis. Increased expression of angiogenic factors in tumors or in blood is associated ...
The majority of non-small-cell lung cancer (NSCLC) patients present with locally advanced (35%) or metastatic disease (40%); in this setting, it is of the utmost importance to balance efficacy with toxicity. However, with ...
Background: We propose that single-nucleotide polymorphisms (SNPs) in genes of the vascular endothelial growth factor pathway of angiogenesis will associate with survival in non-small-cell lung cancer (NSCLC) patients. ...
[EN] The therapeutic options for patients with advanced non-small-cell lung cancer (NSCLC) are palliative. Therefore, the quality of life in oncology is considered as an endpoint in clinical trials, and several scales have ...
[EN] MicroRNAs are one class of small, endogenous, non-coding RNAs that are approximately 22 nucleotides in length; they are very
numerous, have been phylogenetically conserved, and involved in biological processes such ...
Usó, Marta; Jantus Lewintre, Eloisa; Sirera Pérez, Rafael; Bremnes, Roy M.; Camps, Carlos(Future Medicine, 2014)
[EN] Lung cancer is the leading cause of cancer death worldwide. Therefore, advances in the diagnosis and treatment of the disease are urgently needed. miRNAs are a family of small, noncoding RNAs that regulate gene ...
Under the auspices of the Foundation for Excellence and Quality in Oncology (ECO), the Translational Research in Oncology Medical Services Study (INTRO) was conducted with the aim of describing the current state of, and ...
[EN] In May 2007, the Consorcio Hospital General Universitario de Valencia created the position of "Liaison Oncologist". The holder of this position is responsible for coordinating specialised and primary hospital care in ...
[EN] Background: In advanced-stage (IIIB or IV) non-small-cell lung cancer (NSCLC), combination chemotherapy has demonstrated response rates of 20% and a 1-year survival rate of 30%. We conducted a multicentre, open-label, ...
Jantus-Lewintre, Eloisa; Massuti Sureda, Bartomeu; Gonzalez Larriba, Jose Luis; Rodríguez-Abreu, Delvys; Juan, Oscar; Blasco, Ana; Domine, Manuel; Provencio Pulla, Mariano; Garde, Javier; Alvarez, Rosa; Maestu, Inmaculada; Perez de Carrion, Ramon; Artal, Angel; Rolfo, Christian; de Castro, Javier; Camps, Carlos(Frontiers Media SA, 2021-07-26)
[EN] Finding angiogenic prognostic markers in advanced non-small-cell lung cancer is still an unmet medical need. We explored a set of genetic variants in the VEGF-pathway as potential biomarkers to predict clinical outcomes ...
Qualitative analysis of circulating DNA in the blood is a promising non-invasive diagnostic and prognostic tool. Our aim was to study the association between the presence of KRAS mutations at codon 12 and several clinical ...
[EN] Aim: Telomeres are regions of highly repetitive, non-coding DNA located at the termini of chromosomes whose principal function is to maintain the structural stability of these ends. In 90% of human tumours, telomere ...
Bremnes, Roy M.; Donnem, Tom; Al-Saad, Samer; Al-Shibli, Khalid; Andersen, Sigve; Sirera Pérez, Rafael; Camps, Carlos; Marinez, Inigo; Busund, Lill-Tove(Lippincott, Williams & Wilkins, 2011-01)
[EN] Maintenance of both normal epithelial tissues and their malignant counterparts is supported by the host tissue stroma. The tumor stroma mainly consists of the basement membrane, fibroblasts, extracellular matrix, ...
Bremnes, Roy M.; Al-Shibli, Khalid; Donnem, Tom; Sirera Pérez, Rafael; Al-Saad, Samer; Andersen, Sigve; Stenvold, Helge; Camps, Carlos; Busund, Lill-Tove(Lippincott, Williams & Wilkins, 2011-04)
[EN] In addition to malignant neoplastic cells, cancer tissues also include immune cells, fibroblasts, and endothelial cells, including an abundant collection of growth factors, proangiogenic mediators, cytokines, chemokines, ...