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Listar por autor "Coll Merino, María Carmen"

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An aptamer-gated silica mesoporous material for thrombin detection

Oroval Cucarella, María del Mar; Climent Terol, Estela; Coll Merino, Mª Carmen; Eritja, Ramon; Aviñó, Anna; Marcos Martínez, María Dolores; Sancenón Galarza, Félix; Martínez Mañez, Ramón; Amoros del Toro, Pedro Jose (Royal Society of Chemistry, 2013-06-18)

An aptamer-capped mesoporous material for the selective and sensitive detection of &-thrombin in human plasma and serum has been prepared and characterised.
Aplicación del Material Uvm-7 para el Estudio de Puertas Moleculares Nanoscópicas con Apertura Enzimática

Llave Mota, Rocío de la (2021-06-17)

[ES] Existen muchas desventajas asociadas al empleo de determinados fármacos. Éstos se distribuyen en el organismo según sus propiedades físico-químicas. En consecuencia, puede que se encuentren fuera de su intervalo ...
Caspase 3 Targeted Cargo Delivery in Apoptotic Cells Using Capped Mesoporous Silica Nanoparticles

De la Torre Paredes, Cristina; Mondragón Martínez, Laura; Coll Merino, Mª Carmen; García-Fernández, Alba; Sancenón Galarza, Félix; Martínez-Máñez, Ramón; Amorós, Pedro; Pérez Payá, Enrique; Orzáez, Mar (John Wiley & Sons, 2015-10-26)

[EN] Excessive apoptotic cell death is at the origin of several pathologies, such as degenerative disorders, stroke or ischemia-reperfusion damage. In this context, strategies to improve inhibition of apoptosis and other ...
Cathepsin-B Induced Controlled Release from Peptide-Capped Mesoporous Silica Nanoparticles

de la torre, Cristina; Mondragón Martínez, Laura; Coll Merino, Mª Carmen; Sancenón Galarza, Félix; Marcos Martínez, María Dolores; Martínez Mañez, Ramón; Amoros del Toro, Pedro Jose; Pérez Payá, Enrique; Orzáez Calatayud, Mar (Wiley-VCH Verlag, 2014-11-17)

New capped silica mesoporous nanoparticles for intracellular controlled cargo release within cathepsin B expressing cells are described. Nanometric mesoporous MCM-41 supports loaded with safranin O (S1-P) or doxorubicin ...
Design of enzyme-mediated controlled release systems based on silica mesoporous supports capped with ester-glycol groups

Agostini, Alessandro; Mondragón Martínez, Laura; Pascual Vidal, Lluís; Aznar Gimeno, Elena; Coll Merino, Mª Carmen; Martínez Mañez, Ramón; Sancenón Galarza, Félix; Soto Camino, Juan; Marcos Martínez, María Dolores; Amoros del Toro, Pedro; Costero, Ana M.; Parra, Margarita; Gil, Salvador (American Chemical Society, 2012-09-21)

[EN] An ethylene glycol-capped hybrid material for the controlled release of molecules in the presence of esterase enzyme has been prepared. The final organic-inorganic hybrid solid S1 was synthesized by a two-step procedure. ...
Design of novel bio-gated nanomaterials for sensing and therapeutic applications

Oroval Cucarella, María del Mar (Universitat Politècnica de València, 2017-03-20)

The present PhD thesis, entitled "Design of novel bio-gated nanomaterials for sensing and therapeutic applications", is focused on the design, preparation, characterization and evaluation of new smart hybrid organic-inorganic ...
Diseño y síntesis de un nuevo material híbrido orgánico - inorgánico para la detección de trombina

Oroval Cucarella, María del Mar (Universitat Politècnica de València, 2016-02-04)

El presente trabajo está centrado en el desarrollo de sensores basados en nuevos materiales híbridos orgánico-inorgánicos funcionales fruto de la combinación de los principios de la Química Supramolecular y la Ciencia de ...
Drug delivery nanosystems for the localized treatment of glioblastoma multiforme

Nam, L.; Coll Merino, Mª Carmen; Erthal, L.C.S.; De La Torre-Paredes, Cristina; Serrano,D.; Martínez-Máñez, Ramón; Santos-Martinez, M.J.; Ruiz Hernández, E. (MDPI AG, 2018-05)

[EN] Glioblastoma multiforme is one of the most prevalent and malignant forms of central nervous system tumors. The treatment of glioblastoma remains a great challenge due to its location in the intracranial space and the ...
Dual enzyme-triggered controlled release on capped nanometric silica mesoporous supports

Agostini, Alessandro; Mondragón Martínez, Laura; Coll Merino, Mª Carmen; Aznar Gimeno, Elena; Marcos Martínez, María Dolores; Martínez Mañez, Ramón; Sancenón Galarza, Félix; Soto Camino, Juan; Pérez Payá, Enrique; Amoros del Toro, Pedro (Wiley Open Access, 2012)
Enzyme-mediated controlled release systems by anchoring peptide sequences on mesoporous silica supports

Coll Merino, Mª Carmen; Mondragón Martínez, Laura; Martínez Mañez, Ramón; Sancenón Galarza, Félix; Marcos Martínez, María Dolores; Soto Camino, Juan; Amoros del Toro, Pedro Jose; Pérez Payá, Enrique (Wiley-VCH Verlag, 2011-02-01)

Gated community: Peptides anchored to the surface of silica mesoporous supports by a valid procedure act as gatekeepers. In this way, "zero release" supports that selectively deliver the cargo in the presence of a suitable ...
Enzyme-Mediated Controlled Release Systems by Anchoring Peptide Sequences on Mesoporous Silica Supports

Coll Merino, Mª Carmen; Mondragón Martínez, Laura; Martínez Mañez, Ramón; Sancenón Galarza, Félix; Marcos Martínez, María Dolores; Soto Camino, Juan; Amoros del Toro, Pedro Jose; Pérez Payá, Enrique (Wiley-VCH Verlag, 2011-02-25)

[EN] Gated community: Peptides anchored to the surface of silica mesoporous supports by a valid procedure act as gatekeepers. In this way, "zero release" supports that selectively deliver the cargo in the presence of a ...
Functional magnetic mesoporous silica microparticles capped with an azo-derivative: A promising colon drug delivery device

Teruel, Adrián H; Coll Merino, Mª Carmen; Costero, Ana M.; Ferri, Daniel; Parra Álvarez, Margarita; Gaviña, Pablo; Gonzalez -Alvarez, Marta; Merino Sanjuán, Virginia; Marcos Martínez, María Dolores; Martínez-Máñez, Ramón; Sancenón Galarza, Félix (MDPI AG, 2018)

[EN] Magnetic micro-sized mesoporous silica particles were used for the preparation of a gated material able to release an entrapped cargo in the presence of an azo-reducing agent and, to some extent, at acidic pH. The ...
Gated Mesoporous Silica Nanocarriers for a "two-Step" Targeted System to Colonic Tissue

Gonzalez-Alvarez, Marta; Coll Merino, Mª Carmen; Gonzalez-Alvarez, Isabel; Giménez Morales, Cristina; Aznar, Elena; Martínez-Bisbal, M.Carmen; Lozoya Agulló, Isabel; Bermejo, M.; Martínez-Máñez, Ramón; Sancenón Galarza, Félix (American Chemical Society, 2017)

[EN] Colon targeted drug delivery is highly relevant not only to treat colonic local diseases but also for systemic therapies. Mesoporous silica nanoparticles (MSNs) have been demonstrated as useful systems for controlled ...
Gated Mesoporous Silica Nanoparticles Using a Double-Role Circular Peptide for the Controlled and Target-Preferential Release of Doxorubicin in CXCR4-Expresing Lymphoma Cells

De La Torre, Cristina; Casanova, Isolda; Acosta, Gerardo; Coll Merino, Mª Carmen; Moreno, María José; Albericio, Fernando; Aznar, Elena; Mangues, Ramón; Royo, Miriam; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (Wiley, 2015-02-04)

[EN] B-cell non-Hodgkin s lymphoma (B-NHL) is the most frequent malignant lymphoid neoplasm, which has a high degree of relapse and chemoresist-ance. Thus, strategies to improve currently used therapies are needed. In this ...
Gated Silica Mesoporous Supports for Controlled Release and Signaling Applications

Coll Merino, Mª Carmen; Bernardos Bau, Andrea; Martínez Mañez, Ramón; Sancenón Galarza, Félix (American Chemical Society, 2013-02-19)

[EN] Blending molecular and supramolecular advances with materials science has resulted in recent years in the development of new organic-inorganic hybrid materials displaying innovative functionalities. One appealing ...
In Situ-Forming Gels Loaded with Stimuli-Responsive Gated Mesoporous Silica Nanoparticles for Local Sustained Drug Delivery

De La Torre, Cristina; Coll, Carmen; Ultimo, Amelia; Sancenón Galarza, Félix; Martínez-Máñez, Ramón; Ruiz-Hernández, Eduardo (MDPI AG, 2023-04)

[EN] A novel combination of in situ-forming hydrogels of hyaluronic acid with gated mesoporous materials was developed to design depots for local sustained release of chemotherapeutics. The depot consists of a hyaluronic-based ...
Modulation of folic acid bioaccessibility by encapsulation in pH-responsive gated mesoporous silica particles

Pérez-Esteve, Édgar; Fuentes López, Ana; Coll Merino, Mª Carmen; Acosta, Carolina; Bernardos Bau, Andrea; Amoros del Toro, Pedro Jose; Marcos Martínez, María Dolores; Sancenón Galarza, Félix; Martínez-Máñez, Ramón; Barat Baviera, José Manuel (Elsevier, 2015-01-15)

[EN] A study on the controlled release of folic acid (FA) from pH-responsive gated mesoporous silica particles (MSP) is reported. The MCM-41 support was synthesized using tetraethyl orthosilicate (TEOS) as hydrolytic ...
Nanoparticle-cell-nanoparticle communication by stigmergy to enhance poly(I:C) induced apoptosis in cancer cells

Ultimo, Amelia; De La Torre-Paredes, Cristina; Giménez, Cristina; Aznar, Elena; Coll, Carmen; Marcos Martínez, María Dolores; Murguía, Jose R.; Martínez-Máñez, Ramón; Sancenón Galarza, Félix (The Royal Society of Chemistry, 2020-07-07)

[EN] Nanoparticle-cell-nanoparticle communication by stigmergy was demonstrated using two capped nanodevices. The first community of nanoparticles (i.e.S(RA)(IFN)) is loaded with 9-cis-retinoic acid and capped with ...
pH-Dependent Molecular Gate Mesoporous Microparticles for Biological Control of Giardia intestinalis

Gonzalez-Alvarez, Isabel; Vivancos, Verónica; Coll Merino, Mª Carmen; Sánchez-Dengra, B.; Aznar, Elena; Ruiz Picazo, Alejandro; Bermejo, Marival; Sancenón Galarza, Félix; Dea-Ayuela, M. Auxiliadora; Gonzalez -Alvarez, Marta; Martínez-Máñez, Ramón (MDPI AG, 2021-01)

[EN] Giardiasis is a parasitism produced by the protozoa Giardia intestinalis that lives as trophozoite in the small intestine (mainly in the duodenum) attached to the intestinal villus by means of billed discs. The first ...
Selective Fluorogenic Sensing of As(III) Using Aptamer-Capped Nanomaterials

Oroval, Mar; Coll Merino, Mª Carmen; Bernardos Bau, Andrea; Marcos Martínez, María Dolores; Martínez-Máñez, Ramón; Shchukin, D. G.; Sancenón Galarza, Félix (American Chemical Society, 2017)

[EN] Organic-inorganic hybrid nanomaterials offer extremely valuable tools for monitoring many types of analytes in solution. Within this framework, aptamer-based nanomaterials for heavy metal detection are still very ...