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Listar por autor "Limones Herrero, Daniel"

Mostrando ítems 1-9 de 9

A New Pathway for Protein Haptenation by beta-Lactams

Pérez-Ruiz, Raúl; Lence, Emilio; Andreu Ros, María Inmaculada; Limones Herrero, Daniel; González-Bello, Concepción; Miranda Alonso, Miguel Ángel; Jiménez Molero, María Consuelo (John Wiley & Sons, 2017-10-09)

[EN] The covalent binding of beta-lactams to proteins upon photochemical activation has been demonstrated by using an integrated approach that combines photochemical, proteomic and computational studies, selecting human ...
Bypassing the energy barrier of homolytic photodehalogenation in chloroaromatics through self-quenching

Limones Herrero, Daniel; Pérez Ruiz, Raul; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel (American Chemical Society, 2013)

Reductive photodehalogenation of chloroaromatics is assumed to proceed from the triplet excited state, although its energy is often insufficient to promote a clean homolytic C¿Cl cleavage. A clear-cut experimental proof ...
Enhanced photo(geno)toxicity of demethylated chlorpromazine metabolites

Palumbo, Fabrizio; García Lainez, Guillermo; Limones Herrero, Daniel; Coloma, María Dolores; Escobar, Javier; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada (Elsevier, 2016)

Chlorpromazine (CPZ) is an anti-psychotic drug widely used to treat disorders such as schizophrenia or manic-depression. Unfortunately, CPZ exhibits undesirable side effects such as phototoxic and photoallergic reactions ...
Fotoquímica de compuestos heteroaromáticos tricíclicos en medios biomiméticos

Limones Herrero, Daniel (Universitat Politècnica de València, 2016-01-07)

[EN] The use of biomimetic media such as serum albumins (SAs), a1-acid glycloproteins (AAGs), cyclodextrins (CDs) and sodium dodecyl sulfate (SDS) micelles is combined with photophysical techniques (fluorescence (F) and ...
Identification of a common recognition center for a photoactive non-steroidal antiinflammatory drug in serum albumins of different species

Molins-Molina, Oscar; Lence, Emilio; Limones-Herrero, Daniel; González-Bello, Concepción; Miranda Alonso, Miguel Ángel; Jiménez Molero, María Consuelo (Royal Society of Chemistry, 2019-01-07)

[EN] The non-steroidal anti-inflammatory drug (S)-carprofen (CPF) has been used as a photoactive probe to investigate the possible existence of a common recognition center in serum albumins (SAs) of different species. The ...
Investigation of metabolite-protein interactions by transient absorption spectroscopy and in silico methods

Limones Herrero, Daniel; Palumbo, Fabrizio; Vendrell Criado, Victoria; Andreu Ros, María Inmaculada; Lence, Emilio; González-Bello, Concepción; Miranda Alonso, Miguel Ángel; Jiménez Molero, María Consuelo (Elsevier, 2020-02-05)

[EN] Transient absorption spectroscopy in combination with in silico methods has been employed to study the interactions between human serum albumin (HSA) and the anti-psychotic agent chlorpromazine (CPZ) as well as its ...
Mapping a protein recognition centre with chiral photoactive ligands. An integrated approach combining photophysics, reactivity, proteomics and molecular dynamics simulation studies

Limones-Herrero, Daniel; Pérez Ruiz, Raul; Lence, Emilio; Gonzalez-Bello, Concepcion; Miranda Alonso, Miguel Ángel; Jiménez Molero, María Consuelo (The Royal Society of Chemistry, 2017-04-01)

[EN] A multidisciplinary strategy to obtain structural information on the intraprotein region is described here. As probe ligands, (S)- and (R)-CPFMe (the methyl esters of the chiral drug carprofen) have been selected, ...
Photo(geno)toxicity changes associated with hydroxylation of the aromatic chromophores during diclofenac metabolism

García -Laínez, Guillermo; Ana M Marínez-Reig; Limones Herrero, Daniel; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada (Elsevier, 2018)

[EN] Diclofenac (DCF) can cause adverse reactions such as gastrointestinal, renal and cardiovascular disorders; therefore, topical administration may be an attractive alternative to the management of local pain in order ...
Retarded photooxidation of cyamemazine in biomimetic microenvironments

Limones Herrero, Daniel; Pérez Ruiz, Raúl; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel (Wiley, 2014-10)

Cyamemazine (CMZ) is a neuroleptic drug that mediates cutaneous phototoxicity in humans. Here, the photobehavior of CMZ has been examined within (1)-acid glycoproteins, - and -cyclodextrins and SDS micelles. In all these ...