Blay, Gonzalo; Fernández, Isabel; Molina, Eva; Muñoz Roca, María Del Carmen; Pedro, Jose R.; Vila, Carlos(Elsevier, 2006-08-21)
[EN] A diversity-oriented approach to enantiomerically pure densely substituted pyrazoles, ¿-aryl-¿-pyrazolylatrolactic acid and ¿-aryl-¿-pyrazolylacetophenones has been developed. The approach utilises the conjugated ...
Sheikhi, Ehsan; Rezaei, Narjes; Castilla, Alvaro; Sanz-Marco, Amparo; Vila, Carlos; Muñoz Roca, María Del Carmen; Pedro, Jose R.; Blay, Gonzalo(John Wiley & Sons, 2021-10-07)
[EN] An enantioselective organocatalytic addition of sodium bisulfite to (E)-nitroalkenes has been developed by using a chiral bifunctional organocatalyst. The present methodology provides a variety of chiral beta-nitroe ...
Vila, Carlos; Rostoll-Berenguer, Jaume; Sánchez-García, Rubén; Blay, Gonzalo; Fernandez, Isabel; Muñoz Roca, María Del Carmen; Pedro, Jose R.(American Chemical Society, 2018-06-15)
[EN] An asymmetric catalytic reaction of hydroxyindoles with nitroalkenes leading to the Friedel-Crafts alkylation in the carbocyclic ring of indole is presented. The method is based on the activating/directing effects of ...
Blay, Gonzalo; Fernandez, Isabel; Monje, Belen; Muñoz Roca, María Del Carmen; Pedro, Jose R.; Vila, Carlos(Elsevier, 2006-09-22)
[EN] An approach for the synthesis of chiral non-racemic 2-substituted-1,4-diketones from (S)-mandelic acid and ¿,ß-enones has been developed. The reaction of lithium enolate of the 1,3-dioxolan-4-one derived from optically ...
Blay, Gonzalo; Muñoz Roca, María del Carmen; Pedro, Jose R; Sanz-Marco, Amparo(Wiley-VCH Verlag, 2013-04-15)
A new enantioselective catalyst for the
conjugate addition of terminal alkynes has been developed.
Terminal alkynes react with 3-alkoxycarbonylcoumarins
in the presence of diethylzinc and
bis(hydroxyamide) ligands to ...
Martinez-Pardo, Pablo; Blay, Gonzalo; Vila, Carlos; Sanz-Marco, Amparo; Muñoz Roca, María Del Carmen; Pedro, Jose R.(American Chemical Society, 2019)
[EN] The first enantioselective formal [3 + 2] cycloaddition between ¿-isocyanoesters and trifluoromethylketones to give 5-trifluoromethyl-2-oxazolines bearing two contiguous stereogenic centers, one of them being a ...
Blay, Gonzalo; Bargues, Victoria; Cardona, Luz; Collado, Ana M.; García, Begoña; Muñoz Roca, María Del Carmen; Pedro, Jose R.(American Chemical Society, 2000-04-07)
[EN] Hydroxyester 2, easily obtained from santonin (1), has been transformed into 10¿-hydroxyguai-3-en-8,12-olide 6, a good intermediate for the synthesis of natural 8,12-guaianolides. Compound 6 was obtained from 2 by ...