[EN] The differentiation of self-renewing progenitor cells requires not only the regulation of lineage- and developmental stage-specific genes but also the coordinated adaptation of housekeeping functions from a metabolically ...
Galvez-Fernandez, Marta; Sanchez-Saez, Francisco; Domingo-Relloso, Arce; Rodríguez-Hernández, Zulema; Tarazona, Sonia; Gonzalez-Marrachelli, Vannina; Grau-Perez, Maria; Morales-Tatay, José M.; Amigo, Nuria; Garcia-Barrera, Tamara; Gomez-Ariza, Jose L.; Chaves, F. Javier; Garcia-Garcia, Ana Barbara; Melero, Rebeca; Tellez-Plaza, Maria(Elsevier, 2022-06)
[EN] Background: Limited studies have evaluated the joint influence of redox-related metals and genetic variation on metabolic pathways. We analyzed the association of 11 metals with metabolic patterns, and the interacting ...
[EN] Systems medicine and systems biology have inherent educational challenges. These have largely been addressed either by providing new masters programs or by redesigning undergraduate programs. In contrast, short courses ...
[EN] Multi-omic studies combine measurements at different molecular levels to build comprehensive models of cellular systems. The success of a multi-omic data analysis strategy depends largely on the adoption of adequate ...
[EN] Background: Inflammatory and nutritional indexes are prognostic factors in non-small cell lung cancer (NSCLC). Furthermore, a low grade of chronic inflammation has been described in the older population (inflammaging). ...
Martínez Mira, Carlos(Universitat Politècnica de València, 2015-10-22)
[ES] Los avances en tecnologías de secuenciación masiva permiten obtener datos de expresión génica y también de sus elementos reguladores y productos. Integrar estas medidas multiómicas en un modelo estadístico que explique ...
Laborda Cenjor, Rafael; Bertomeu Cucart, Salvador; Sánchez Domingo, Adrián; Xamaní Monserrat, Pilar; Tarazona Campos, Sonia; Ibañez, J.M.; García Prats, Alberto; García Mari, Ferran(International Organization for Biological and Integrated Control of Noxious Animals and Plants, West Palearctic Regional Section (IOBC-WPRS), 2013)
[EN] We performed a study in nineteen citrus plots representative of the agricultural landscape of
the municipality of Altea (100 km south of Valencia, in eastern Spain) in order to determine the
influence of ecological ...
Bernabeu Gómez, Elena(Universitat Politècnica de València, 2016-07-28)
[EN] In recent years the omics disciplines have made their way across a wider spectrum of
research groups, thus leading to the generation of multi-omics data sets in a great number of
studies. While traditional omics ...
Debón Aucejo, Ana María; Tarazona Campos, Sonia; Doménech i de Soria, Josep; Polo Garrido, Fernando(Editorial Universitat Politècnica de València, 2021-09-28)
[EN] The Universitat Politècnica de València and its Faculty of Business Administration and Management have created a new intensification, named, "Intelligent Data Analysis", that provides the student with sufficient ...
González-Cebrián, Alba; Borràs-Ferrís, Joan; Ordovás-Baines, Juan Pablo; Hermenegildo-Caudevilla, Marta; Climente-Martí, Mónica; Tarazona, Sonia; Vitale, Raffaele; Palací-López, Daniel; Sierra-Sánchez, Jesús Francisco; Saez de la Fuente, Javier; Ferrer, Alberto(Public Library of Science, 2022-09-22)
[EN] The clinical course of COVID-19 is highly variable. It is therefore essential to predict as early and accurately as possible the severity level of the disease in a COVID-19 patient who is admitted to the hospital. ...
Lucas Blázquez, Óscar(Universitat Politècnica de València, 2023-10-24)
[ES] El selenio es un micro-nutriente esencial para la mayoría de los organismos, incluidos los humanos, y juega un papel clave en una gran variedad de procesos biológicos mediados por las selenoproteínas. Tanto el exceso ...
Tomás Riquelme, Blanca(Universitat Politècnica de València, 2019-01-09)
Los avances recientes en las tecnologías de secuenciación nos han brindado una oportunidad sin precedentes para entender mejor el papel de la genómica, epigenética y transcriptómica en la regulación de la expresión génica. ...
Rubio Martínez-Abarca, María Teresa(Universitat Politècnica de València, 2022-09-01)
[ES] El objetivo principal de este trabajo fue conocer las alteraciones inmunológicas asociadas a la inflamación periférica que desencadenan deterioro cognitivo en los pacientes cirróticos encefalopatía hepática mínima ...
[EN] Diversity of omic technologies has expanded in the last years together with the number of omic data integration strategies. However, multiomic data generation is costly, and many research groups cannot afford research ...
Ugidos, Manuel; Nueda, María José; Prats-Montalbán, José Manuel; Ferrer, Alberto; Conesa, Ana; Tarazona, Sonia(Oxford University Press, 2022-04-28)
[EN] Motivation: Batch effects in omics datasets are usually a source of technical noise that masks the biological signal and hampers data analysis. Batch effect removal has been widely addressed for individual omics ...
[EN] Retinitis pigmentosa (RP) is a rare, progressive disease that affects photoreceptors and retinal pigment epithelial (RPE) cells with blindness as a final outcome. Despite high medical and social impact, there is ...
Rodríguez Martínez, Eduardo(Universitat Politècnica de València, 2021-10-07)
[ES] El estudio de diferentes redes basadas en la COVID-19 puede proporcionar un enfoque sistemático para explorar los repositorios de medicamentos al tiempo que se tienen en cuenta otros factores multidimensionales que ...
Nueda, María José; Tarazona Campos, Sonia; Conesa, Ana(Oxford University Press (OUP): Policy B - Oxford Open Option B, 2014-09-15)
[EN] Motivation: The widespread adoption of RNA-seq to quantitatively
measure gene expression has increased the scope of sequencing
experimental designs to include time-course experiments. maSigPro
is an R package ...
[EN] The increasing availability of multi-omic platforms poses new challenges to data analysis. Joint visualization of multi-omics data is instrumental in better understanding interconnections across molecular layers and ...
[EN] PaintOmics is a web server for the integrative analysis and visualisation of multi-omics datasets using biological pathway maps. PaintOmics 4 has several notable updates that improve and extend analyses. Three pathway ...