CLEMMENTS, ALDEN MICHAEL; Muniesa Lajara, Carlos; Landry, Christopher Caron; Botella Asuncion, Pablo(Royal Society of Chemistry, 2014)
[EN] The composition of the protein corona formed on mesoporous silica nanoparticles with several surface modifications was characterized. Low MW serum proteins were preferentially adsorbed, and PEGylated nanoparticles did ...
Muniesa Lajara, Carlos; Vicente Vilas, Victor; Quesada Vilar, Manuel; SAEZ-ATIENZAR, SARA; BLESA-BLESA, JOSE RAFAEL; Abasolo, Ibane; Fernández, Yolanda; Botella Asuncion, Pablo(Royal Society of Chemistry, 2013)
[EN] We report the design, synthesis, characterization and in vitro testing of a novel nanodrug based on a covalent linking model that allows intracellular controlled release of the pharmaceutical payload. A new synthetic ...
[EN] A novel type of hybrid material based on a PLGA nanoparticle core and a redox-responsive amorphous organosilica shell have been successfully synthesized. The outer layer is obtained by self-assembly of silicate ions ...
Muniesa Lajara, Carlos(Universitat Politècnica de València, 2013-06-14)
El desarrollo de nanofármacos aplicados en terapias frente al cáncer es
un prometedor campo de la biomedicina en el cual se entrecruzan diferentes
disciplinas científicas como la biología, la ciencia de los materiales, ...
[EN] Here we report the design, synthesis and biological evaluation of surface-modified silica nanoparticles (SNP) for the delivery of camptothecin (CPT). Drug has been covalently linked to the nanoparticle through an ester ...