Mora Fenoll, María Teresa; Gómez García, Juan Francisco; Ferrero De Loma-Osorio, José María; Trénor Gomis, Beatriz Ana(Universitat Politècnica de València, 2019)
The functional coupling between myocytes and fibroblasts can alter the electrophysiology of myocytes, which is a major problem in heart failure. The code provides the mathematical model to simulate this interaction, and ...
Mora-Fenoll, María Teresa; Ferrero De Loma-Osorio, José María; Gómez García, Juan Francisco; Sobie, Eric A.; Trenor Gomis, Beatriz Ana(Frontiers Media SA, 2018-08-23)
[EN] Heart failure (HF) is characterized by altered Ca2+ cycling, resulting in cardiac contractile dysfunction. Failing myocytes undergo electrophysiological remodeling, which is known to be the main cause of abnormal Ca2+ ...
Llopis-Lorente, Jordi; Baroudi, Samuel; Koloskoff, Kévin; Romero Pérez, Lucia; Mora-Fenoll, María Teresa; Basset, Matthieu; Benito, Sylvain; Dayan, Frederic; Saiz Rodríguez, Francisco Javier; Trénor Gomis, Beatriz Ana(RiuNet (Repositorio institucional de la Universitat Politècnica de València), 2023-03-29)
This repository contains the code used to generate the male and female population of models and simulate the different pharmacokinetic scenarios in Llopis-Lorente et al. (2023). Combining pharmacokinetic and electrophysiological ...
[EN] Background and Objective: In silico methods are gaining attention for predicting drug-induced Torsade de Pointes (TdP) in different stages of drug development. However, many computational models tended not to account ...
Ferre Martínez, Jordi(Universitat Politècnica de València, 2020-10-28)
[ES] La insuficiencia cardíaca constituye hoy en día uno de los principales problemas sanitarios en los países desarrollados. Esta patología altera de manera significativa la actividad eléctrica celular de los ventrículos. ...
Ferre Martínez, Jordi(Universitat Politècnica de València, 2022-09-05)
[ES] La insuficiencia cardiaca es una patología que afecta una gran parte de la población causando problemas de morbilidad e incluso mortalidad, debido al insuficiente bombeo de sangre y al incremento de la vulnerabilidad ...
Gil Mengual, Carla Caterina(Universitat Politècnica de València, 2021-09-09)
[ES] Según la OMS, la insuficiencia cardíaca es la tercera causa de muerte en patologías cardiovasculares en países desarrollados. Este trabajo se centra en estudiar mediante simulación computacional los cambios electromecánicos ...
Martín de la Sierra Rodríguez Bobada, Alberto(Universitat Politècnica de València, 2021-10-18)
[ES] Las arritmias cardiacas representan hoy en día una de las principales causas de mortalidad en los países desarrollados. Además, el desorden de la actividad eléctrica desencadena problemas en la contracción cardíaca. ...
Mora Fenoll, Mª Teresa(Universitat Politècnica de València, 2020-10-26)
[EN] Heart failure, a cardiomyopathy that produces mechanical dysfunction and sudden cardiac death following fatal arrhythmias, is one of the main causes of mortality worldwide that also causes elevated morbidity rates. ...
Ruiz Gálvez, Cristóbal Rubén; Gómez García, Juan Francisco; Mora Fenoll, Mª Teresa; Osca Asensi, Joaquín; Izquierdo de Francisco, Maria Teresa; Trénor Gomis, Beatriz Ana(Universitat Politècnica de València, 2024-05-23)
[EN] This dataset contains simulation data to represent the 12 ECG leads for every scenario simulated in the study by Ruiz et al. (2024) entitled: In Silico Systematic Evaluation of the Scar Effect in Conventional and New ...
Mora-Fenoll, María Teresa; Zaza, Antonio; Trenor Gomis, Beatriz Ana(Elsevier, 2023-01-21)
[EN] Background and objective: Structural and electrical remodeling in heart failure predisposes the heart to
ventricular arrhythmias. Computer modeling approaches, used to complement experimental results, can
provide a ...
Mora-Fenoll, María Teresa; Gomez, Juan F.; Morley, Gregory; Ferrero De Loma-Osorio, José María; Trenor Gomis, Beatriz Ana(Public Library of Science, 2019-06-18)
[EN] Heart failure (HF) is characterized, among other factors, by a progressive loss of contractile function and by the formation of an arrhythmogenic substrate, both aspects partially related to intracellular Ca2+ cycling ...
Mora Fenoll, María Teresa(Universitat Politècnica de València, 2016-06-27)
[EN] Many sudden cardiac death cases by ventricular fibrillation are associated with the acute phase of myocardial ischemia. During the first minutes after coronary occlusion several metabolic changes take place, and ...
Mora-Fenoll, María Teresa; Gutiérrez, Sofía; Dasi, Albert; Gómez García, Juan Francisco; Trenor Gomis, Beatriz Ana(IEEE, 2020-09-16)
[EN] Intracellular Ca2+ is the main activator of myofilament contraction and the altered Ca2+ handling observed in failing cells has been established as the leading cause of reduced inotropy in heart failure. ...
Mora Fenoll, María Teresa; Ferrero De Loma-Osorio, José María; Romero Pérez, Lucia; Trénor Gomis, Beatriz Ana(Public Library of Science, 2017)
[EN] Abnormal intracellular Ca2+ handling is the major contributor to the depressed cardiac contractility observed in heart failure. The electrophysiological remodeling associated with this pathology alters both the action ...
Mora-Fenoll, María Teresa; Gong, Jingqi Q. X.; Sobie, Eric A.; Trenor Gomis, Beatriz Ana(Elsevier, 2021-04)
[EN] ß-adrenergic receptor antagonists (ß-blockers) are extensively used to improve cardiac performance in heart failure (HF), but the electrical improvements with these clinical treatments are not fully understood. The ...