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Listar por autor "Rodríguez Berna, Guillermo"

Mostrando ítems 1-3 de 3

Covalently crosslinked organophosphorous derivatives-chitosan hydrogel as a drug delivery system for oral administration of camptothecin

Martínez-Martínez, M.; Rodríguez Berna, Guillermo; Bermejo, Marival; Gonzalez-Alvarez, Isabel; Gonzalez -Alvarez, Marta; Merino, Virginia (Elsevier, 2019-03)

[EN] Hydrogels are widely studied as drug delivery system. In this work we propose the employment of tetrakis (hydroxymethyl)phosphonium chloride as crosslinking agent to obtain covalent hydrogels based on chitosan. These ...
Estudios semisintéticos y biológicos de 20-(S)-Camptotecina en terapia antitumoral y obtención de materiales porosos en condiciones biomiméticas

Rodríguez Berna, Guillermo (Universitat Politècnica de València, 2016-04-05)

[EN] This thesis is divided in two parts covering the fields of medicinal chemistry and science materials, respectively. In the first part, the semisynthesis of new derivatives of the antitumor drug 20-(S)-Camptothecin ...
Ionic Hydrogel Based on Chitosan Cross-Linked with 6-Phosphogluconic Trisodium Salt as a Drug Delivery System

Martínez Martínez, Mayte; Rodríguez Berna, Guillermo; Gonzalez-Alvarez, Isabel; Hernández, María Jesús; Corma Canós, Avelino; Bermejo, Marival; Merino Sanjuán, Virginia; Gonzalez -Alvarez, Marta (American Chemical Society, 2018-04)

[EN] In this work, 6-phosphogluconic trisodium salt (6-PG(-)Na(+)) is introduced as a new aqueous and nontoxic cross-linking agent to obtain ionic hydrogels. Here, it is shown the formation of hydrogels based on chitosan ...

Mostrando ítems 1-3 de 3

Listar por autor "Rodríguez Berna, Guillermo"

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Listar por autor "Rodríguez Berna, Guillermo"