Rodríguez Muñiz, Gemma María; Gomez Mendoza, Miguel; Nuin Pla, Neus Edurne; Andreu Ros, María Inmaculada; Marín García, Mª Luisa; Miranda Alonso, Miguel Ángel(The Royal Society of Chemistry, 2017)
[EN] A photoactive bathymeter based on a carboxylic acid moiety covalently linked to a signalling methoxynaphthalene (MNP) fluorophore has been designed to prove the concept of "snorkelling" vs. "diving" in mixed micelles ...
Oliverio, Filomena; Nuin Plá, Neus Edurne; Andreu Ros, María Inmaculada; Ragno, Gaetano; Miranda Alonso, Miguel Ángel(Elsevier, 2014-10)
The photophysical and photochemical behavior of (R)-cinacalcet (CIN) and (S)-naproxen (NPX) entrapped within liposomes has been studied. For this purpose, liposome encapsulated drugs have been prepared through thin layer ...
Nuin Pla, Neus Edurne; Sastre Navarro, German Ignacio; Pischel, Uwe; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel(John Wiley & Sons, 2015)
[EN] Novel diastereomeric triads containing two naphthalene chromophores have been designed in which an electron-donating amine moiety is covalently integrated into the connecting bridge. Photophysical studies (steady-state ...
Nuin Plá, Neus Edurne; Jiménez Molero, María Consuelo; Sastre Navarro, German Ignacio; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel(American Chemical Society, 2013-05-16)
A new direct and noninvasive methodology based on transient absorption spectroscopy has been developed to probe the feasibility of drug-drug interactions within a common protein binding site. The simultaneous presence of ...
Nuin Plá, Neus Edurne; Andreu Ros, María Inmaculada; Torres, Maria Jose; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(American Chemical Society, 2011-02-10)
Cinacalcet (CIN) is a calcimimetic drug, which contains a naphthalene chromophore and binds almost quantitatively to human serum albumin (HSA). In the present work, the excited states of CIN have been characterized in order ...
Mayorga, Cristobalina; Andreu Ros, María Inmaculada; Aranda, Ana; Doña, Inmaculada; Montañez, M. Isabel; Blanca-López, Natalia; Ariza, Adriana; Nuin Plá, Neus Edurne; Blanca, Miguel; Miranda Alonso, Miguel Ángel; Torres, Mª José(Karger, 2013)
Fluoroquinolones (FQs) are photoreactive drugs, but it is not known whether laboratory light exposure can influence the induction of photoproducts and modify in vitro test results. The basophil activation test (BAT) has ...
Khramtsova, E.A.; Sosnovsky, D.V.; Ageeva, A.A.; Nuin Plá, Neus Edurne; Marín García, Mª Luisa; Purtov, P.A.; Borisevich, S.S.; Khursan, S.L.; Roth, H.D.; Miranda Alonso, Miguel Ángel; Plyusnin, V.F.; Leshina, T.V.(Royal Society of Chemistry, 2016-05-14)
[EN] The model reaction of photoinduced donor-acceptor interaction in linked systems (dyads) has been used to study the comparative reactivity of a well-known anti-inflammatory drug, (S)-naproxen (NPX) and its (R)-isomer. ...
Nuin Plá, Neus Edurne; Gómez Mendoza, Miguel; Marín García, Mª Luisa; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel(American Chemical Society, 2013-08-15)
Photophysical techniques, specifically time-resolved fluorescence and laser flash photolysis, have proven to be noninvasive, straightforward, and valuable tools to demonstrate how drug encapsulation into biomimetic mixed ...
Magin, I.M.; Polyakov, N.E.; Kruppa, A. I.; Purtov, P.A.; Leshina, T. V.; Kiryutin, A. S.; Miranda Alonso, Miguel Ángel; Nuin Plá, Neus Edurne; Marín García, Mª Luisa(Royal Society of Chemistry, 2016-01-14)
[EN] Photoinduced processes with partial (exciplex) and full charge transfer in donor-acceptor systems are of interest because they are frequently used for modeling drug-protein binding. Low field photo-CIDNP (chemically ...
Pérez Ruiz, Raúl; Alonso Ruiz, Rafael; Nuin Plá, Neus Edurne; Andreu Ros, María Inmaculada; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(American Chemical Society, 2011-04-21)
[EN] Three drugs containing the naphthalene (NP) chromophore, namely, naproxen (NPX), propranolol (PPN), and cinacalcet (CIN), but with different affinities toward serum albumins (SAs) and alpha-1-acid glycoproteins (AAGs) ...
Nuin Plá, Neus Edurne; Gómez Mendoza, Miguel; Andreu Ros, María Inmaculada; Marín García, Mª Luisa; Miranda Alonso, Miguel Ángel(American Chemical Society, 2013-01-18)
New photoactive dyads have been synthesized by derivatization of cholic acid (CA) or cholesterol (Ch). These compounds have proven to be efficient tools to monitor incorporation of CA and Ch to mixed micelles (MM) and to ...
Gómez Mendoza, Miguel; Nuin Plá, Neus Edurne; Andreu Ros, María Inmaculada; Marín García, Mª Luisa; Miranda Alonso, Miguel Ángel(American Chemical Society, 2012-08-30)
The two enantiomers of the nonsteroidal antiinflammatory drug naproxen and of its methyl ester have been selected as representative probes with markedly different hydrophobicity to assess the potential of cholic acid ...
Nuin Pla, Neus Edurne; Pérez-Sala, Dolores; Lhiaubet-Vallet, Virginie Lyria; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel(Frontiers Media SA, 2016)
[EN] Triflusal is a platelet aggregation inhibitor chemically related to acetylsalicylic acid, which is used for the prevention and/or treatment of vascular thromboembolisms, which acts as a prodrug. Actually, after oral ...
Khramtsova, Ekaterina A.; Plyusnin, Viktor F.; Magin, Ilya M.; Kruppa, Alexander I.; Polyakov, Nikolay E.; Leshina, Tatyana V.; Nuin Plá, Neus Edurne; Marín García, Mª Luisa; Miranda Alonso, Miguel Ángel(American Chemical Society, 2013-12-19)
The influence of chirality on the elementary processes triggered by excitation of the (S,S)- and (R,S)- diastereoisomers of naproxen-pyrrolidine (NPX-Pyr) dyads has been studied by time-resolved fluorescence in ...