Lozano-Torres, Beatriz; Blandez, Juan F.; Galiana, Irene; Lopez-Dominguez, Jose Alberto; Rovira, Miguel; Páez-Ribes, Marta; González-Gualda, Estela; Muñoz-Espín, Daniel; Serrano, Manuel; Sancenón Galarza, Félix; Martínez-Máñez, Ramón(American Chemical Society, 2021-02-09)
[EN] Cellular senescence is a state of stable cell cycle arrest that can negatively affect the regenerative capacities of tissues and can contribute to inflammation and the progression of various aging-related diseases. ...
[EN] Senescent cells accumulate in multiple aging-associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal beta-galactosidase ...
[EN] Triple-negative breast cancer (TNBC) is a very aggressive subtype of breast cancer with a poor prognosis and limited effective therapeutic options. Induction of senescence, arrest of cell proliferation, has been ...
Galiana Guillem, Irene(Universitat Politècnica de València, 2016-05-25)
[EN] The main goal of the current project is the design and synthesis of new nanomaterials for the detection and elimination of senescent cells, focused on the treatment of senescence-related diseases such as idiopathic ...
Galiana Guillem, Irene(Universitat Politècnica de València, 2020-10-15)
[ES] La presente tesis doctoral, titulada “Desarrollo de nuevos nanodispositivos
terapéuticos aplicados al tratamiento de enfermedades relacionadas con procesos
de senescencia”, está centrada en el diseño, preparación, ...
Blasco Carrasco, Jordi(Universitat Politècnica de València, 2017-10-10)
[ES] La senescencia celular es un estado que se caracteriza por un arresto del ciclo celular
permanente y un fenotipo hipersecretor asociado. Originalmente se atribuyó al envejecimiento
celular, pero hoy se sabe que puede ...
Mas Font, Nuria; Galiana Guillem, Irene; Mondragón Martínez, Laura; Aznar Gimeno, Elena; Climent Terol, Estela; Cabedo Escrig, Nuria; Sancenón Galarza, Félix; Murguía Ibáñez, José Ramón; Martínez Mañez, Ramón; Marcos Martínez, María Dolores; Amoros del Toro, Pedro(Wiley-VCH Verlag, 2013-07-09)
[EN] A novel nanodevice consisting of mesoporous nanoparticles loaded with vancomycin and capped with epsilon-poly-L-lysine (epsilon-PL) was prepared and its interaction with different Gram-negative bacteria studied. A ...
[EN] The induction of senescence produces a stable cell cycle arrest in cancer cells, thereby inhibiting tumor growth; however, the incomplete immune cell-mediated clearance of senescent cells may favor tumor relapse, ...
[EN] In vivo detection of cellular senescence is accomplished by using mesoporous silica nanoparticles loaded with the NIR-FDA approved Nile blue (NB) dye and capped with a galactohexasaccharide (S3). NB emission at 672 ...