Pascual-Ahuir Giner, María Desamparados; Manzanares-Estreder, Sara; Timón Gómez, Alba; Proft ., Markus Hans(Springer-Verlag, 2017)
[EN] Here, we review and update the recent advances in the metabolic control during the adaptive response of budding yeast to hyperosmotic and salt stress, which is one of the best understood signaling events at the molecular ...
Manzanares Estreder, Sara(Universitat Politècnica de València, 2017-03-27)
In the present work we study the metabolic adaptation in response to stress in the yeast model, and more specifically we investigate the regulation of peroxisomal activity and the metabolism of sphingolipids.
Peroxisomes ...
Manzanares-Estreder, Sara; Espí Bardisa, Joan; Pascual-Ahuir Giner, María Desamparados; Proft, Markus Hans(Blackwell Publishing, 2016)
[EN] Peroxisomes are dynamic organelles and the sole location for fatty acid ß-oxidation in yeast cells. Here, we report that peroxisomal function is crucial for the adaptation to salt stress, especially upon sugar limitation. ...
Manzanares Estreder, Sara(Universitat Politècnica de València, 2015-07-01)
[EN] In the present work the physiological consequences of sphingolipid degradation was studied, which is conserved between yeast and humans. In this metabolic pathway, sphingosine–1–phosphate and dihydrosphingosine are ...
Pascual-Ahuir Giner, María Desamparados; Manzanares-Estreder, Sara; Proft, Markus(Hindawi Limited, 2017)
[EN] Peroxisomes and mitochondria are the main intracellular sources for reactive oxygen species. At the same time, both organelles are critical for the maintenance of a healthy redox balance in the cell. Consequently, ...
Manzanares-Estreder, Sara; Pascual-Ahuir Giner, María Desamparados; Proft, Markus(Hindawi Limited, 2017)
[EN] Sphingolipids are regulators of mitochondria-mediated cell death in higher eukaryotes. Here, we investigate how changes in sphingolipid metabolism and downstream intermediates of sphingosine impinge on mitochondrial ...