Mengual-Chuliá, Beatriz; Bedhomme, Stephanie; Lafforgue, Guillaume; Elena Fito, Santiago Fco; Bravo, Ignacio G.(BioMed Central, 2016-02-05)
Background: The increasing abundance of sequence data has exacerbated a long known problem: gene trees and species trees for the same terminal taxa are often incongruent. Indeed, genes within a genome have not all followed ...
Lafforgue, Guillaume; Sardanyes Cayuela, Jose; Elena Fito, Santiago Fco(Public Library of Science, 2011-03-15)
[EN] Understanding the evolution of virulence for RNA viruses is essential for developing appropriate control strategies.
Although it has been usually assumed that virulence is a consequence of within-host replication of ...
Lafforgue, Guillaume; Tromas, Nicolas; Elena Fito, Santiago Fco; Zwart, Mark Peter(American Society for Microbiology, 2012)
[EN] In the clinic, farm, or field, for many viruses there is a high prevalence of mixed-genotype infections, indicating that multiple virions have initiated infection and that there can be multiple sites of primary infection ...
Bedhomme, Stephanie; Lafforgue, Guillaume; Elena Fito, Santiago Fco(BioMed Central, 2013-02-19)
[EN] Background: The importance of historical contingency in determining the potential of viral populations to evolve has been largely unappreciated. Identifying the constraints imposed by past adaptations is, however, of ...
Lafforgue, Guillaume; Martínez, Fernando; Niu, Qi Wen; Chua, Nam Hai; Daros Arnau, Jose Antonio; Elena Fito, Santiago Fco(American Society for Microbiology, 2013-07)
[EN] A drawback of recent antiviral therapies based on the transgenic expression of artificial microRNAs (amiRs) is the ease with
which viruses generate escape mutations. Here, we show two alternative strategies for ...
Bedhomme, Stephanie; Lafforgue, Guillaume; Elena Fito, Santiago Fco(Oxford University Press (OUP), 2012-05)
[EN] For multihost pathogens, adaptation to multiple hosts has important implications for both applied and basic research. At the applied level, it is one of the main factors determining the probability and the severity ...
Elena Fito, Santiago Fco; Bedhomme, Stephanie; Carrasco, Purificación; Cuevas, Jose M.; De la Iglesia Jordán, Francisca; Lafforgue, Guillaume; Lalic, Jasna; Prosper Pontones, Angels; Tromas, Nicolas; Zwart, Mark Peter(American Phytopathological Society, 2011-03)
[EN] Over the years, agriculture across the world has been compromised by a succession of devastating epidemics caused by new viruses that spilled over from reservoir species or by new variants of classic viruses that ...
Martinez Garcia, Fernando; Lafforgue, Guillaume; Morelli, M.; González-Candelas, F.; CHUA, N.H.; Daros Arnau, Jose Antonio; Elena Fito, Santiago Fco(Oxford University Press (OUP), 2012-11)
[EN] Plant artificial micro-RNAs (amiRs) have been engineered to target viral genomes and induce their degradation. However, the exceptional evolutionary plasticity of RNA viruses threatens the durability of the resistance ...