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Listar por autor "Dopazo Blazquez, Joaquin"

Mostrando ítems 1-9 de 9

Alteraciones en la comunicación entre rutas de señalización: un estudio transversal en cáncer

Nebot Forcada, Pau (Universitat Politècnica de València, 2016-10-17)

[ES] El cáncer se describe como un conjunto de enfermedades caracterizadas por un desarrollo tisular incontrolado, donde las células afectadas consiguen evadir los mecanismos intrínsecos de control frente a la muerte celular ...
Estudio de la heterogeneidad regulatoria en cáncer y sus implicaciones en la medicina personalizada

Marín Falco, Matías (Universitat Politècnica de València, 2021-03-08)

[ES] El cáncer es la segunda causa de muerte en el mundo y se caracteriza principalmente por la proliferación descontrolada de las células que forman el tumor. Aunque el desarrollo de un tumor es posible debido a ciertos ...
Fast inexact mapping using advanced tree exploration on backward search methods

Salavert Torres, José; Tomás Domínguez, Andrés Enrique; Tárraga Giménez, Joaquín; Medina Castelló, Ignacio; Dopazo Blazquez, Joaquin; Blanquer Espert, Ignacio (BioMed Central, 2015-01-28)

Background: Short sequence mapping methods for Next Generation Sequencing consist on a combination of seeding techniques followed by local alignment based on dynamic programming approaches. Most seeding algorithms are ...
Functional profiling of human genomic data using the protein interactome

García Alonso, Luz María (Universitat Politècnica de València, 2015-10-13)

[EN] Our understanding of the biological mechanisms for most common human diseases is far from complete. Even with well established genetic landscapes, our capacity to make accurate phenotypical predictions or determine ...
Modeling Functional Modules Using Statistical and Machine Learning Methods

Cubuk, Cankut (Universitat Politècnica de València, 2020-11-30)

[ES] La comprensión de los aspectos de la funcionalidad de las células que cuentan para los mecanismos de las enfermedades es el mayor reto de la medicina personalizada. A pesar de la disponibilidad creciente de los datos ...
Pathway Activity Analysis (PAA) as a new class of mechanistic biomarker to predict drug responses in drug repositioning for cancer patients

Bailach Adsuara, Anna (Universitat Politècnica de València, 2017-09-05)

[EN] In recent years, progress in new technologies has resulted in the capacity to generate massive amounts of data, this is known as the "Omics Age". The challenge now is data integration and analysis. Thus, Systems ...
Protein-protein interaction networks and genome-scale experiments integration to identify disease associated subnetworks

García Alonso, Luz María (Universitat Politècnica de València, 2012-05-25)

It has become clear that the cell is a complex system that can not be described by the action of their isolated components. To study a cell state it is necessary not only to focus on its individual components but also ...
Using GPUs for the exact alignment of short-read genetic sequences by means of the Burrows-Wheeler transform

Salavert Torres, José; Blanquer Espert, Ignacio; Tomás Domínguez, Andrés Enrique; Hernández García, Vicente; Medina Castelló, Ignacio; Tárraga Giménez, Joaquín; Dopazo Blazquez, Joaquin (Association for Computing Machinery (ACM)Institute of Electrical and Electronics Engineers (IEEE), 2012-07)

General Purpose Graphic Processing Units (GPGPUs) constitute an inexpensive resource for computing-intensive applications that could exploit an intrinsic fine-grain parallelism. This paper presents the design and ...
Uso de datos genómicos para la búsqueda de reguladores de importancia en cáncer

Marín Falco, Matías (Universitat Politècnica de València, 2015-10-22)

[EN] This TFG will compare a transcription facto database with gene expression data availables on different cancer types in order to find common regulation processes. To this aim, RNA-Seq files at the International Cancer ...