de Luis-Fernández, Beatriz; García-Fernández, Alba; Llopis-Lorente, Antoni; Villalonga, Reynaldo; Sancenón Galarza, Félix; Martínez-Máñez, Ramón(The Royal Society of Chemistry, 2020-09-07)
[EN] A biocomputing strategy implemented in hybrid nanocarriers for controlled cargo delivery is described. The nanodevice consists of enzyme-functionalized Janus Au-mesoporous silica nanoparticles, which behave as an ...
Godoy-Reyes, Tania Mariel; Llopis-Lorente, Antoni; García-Fernández, Alba; Gaviña, Pablo; Costero, Ana M.; Martínez-Máñez, Ramón; Sancenón Galarza, Félix(The Royal Society of Chemistry, 2019)
[EN] Mesoporous silica nanoparticles capped with acetylcholinesterase, through boronic ester linkages, selectively release an entrapped cargo in the presence of acetylcholine.
Lozano-Torres, Beatriz; García-Fernández, Alba; Domínguez-Rodríguez, Marcia; Sancenón Galarza, Félix; Blandez, Juan F.; Martínez-Máñez, Ramón(American Chemical Society, 2023-01-17)
[EN] Cellular senescence is a stable cell cycle arrest in response to stress or other damage stimuli to maintain tissue
homeostasis. However, the accumulation of senescent cells can lead to the progression of various ...
[EN] Excessive apoptotic cell death is at the origin of several pathologies, such as degenerative disorders, stroke or ischemia-reperfusion damage. In this context, strategies to improve inhibition of apoptosis and other ...
[EN] Triple-negative breast cancer (TNBC) is a very aggressive subtype of breast cancer with a poor prognosis and limited effective therapeutic options. Induction of senescence, arrest of cell proliferation, has been ...
Prieto-Castañeda, Alejandro; García-Garrido, Fernando; Díaz-Norambuena, Carolina; Escriche-Navarro, Blanca; García-Fernández, Alba; Bañuelos, Jorge; Rebollar, Esther; García-Moreno, Inmaculada; Martínez-Máñez, Ramón; de la Moya, Santiago; Agarrabeitia, Antonia R.; Ortiz, María J.(American Chemical Society, 2022-05-27)
[EN] We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprece-dented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key ...
[EN] The characteristics and electromechanical properties of conductive polymers together to their biocompatibility
have boosted their application as a suitable tool in regenerative medicine and tissue engineering. ...
[EN] The introduction of stimuli-responsive cargo release capabilities on self-propelled micro- and nano- motors holds enormous potential in a number of applications in the biomedical field. Herein, we report the preparation ...
García Fernández, Alba(Universitat Politècnica de València, 2020-11-08)
[ES] La presente tesis doctoral titulada "Nanomateriales con puertas moleculares como plataforma de liberación controlada de fármacos para el tratamiento de desórdenes inflamatorios" se centra la preparación y evaluación ...
[EN] Here we describe the construction of an integrated and pH-sensitive nanomachine with layer-by-layer supramolecular design and enzymatic control for on-command delivery. The nanodevice comprises a first layer of ...
[EN] Introduction: Breast cancer has the highest mortality rate among cancers in women. Patients suffering from certain breast cancers, such as triple-negative breast cancer (TNBC), lack effective treatments. This represents ...
[EN] Here, we present the design of smart nano-devices capable of reading molecular information from the environment and acting accordingly by processing Boolean logic tasks. As proof of concept, we prepared Au-mesoporous ...
[EN] A new method for senescent cell detection is described, which is based on lipofuscin labeling with a fluorescent reporter through a biorthogonal strain-promoted azide-alkyne cycloaddition. The sensing protocol involves ...
[EN] An increase of bone diseases incidence has boosted the study of ceramic biomaterials as potential osteo-inductive scaffolds. In particular, mesoporous bioactive glasses have demonstrated to possess a broad application ...
[EN] Cancer immunotherapy has emerged in the past decade as a promising strategy for treating many forms of cancer by stimulating the patient's immune system. Although immunotherapy has achieved some promising results in ...
[EN] Over the last years, respiratory diseases represent a clinical concern, being included among the leading causes of death in the world due to the lack of effective lung therapies, mainly ascribed to the pulmonary ...
[EN] Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. In the last years, navitoclax has emerged as a possible treatment for TNBC. Nevertheless, rapid navitoclax resistance onset has been ...
García-Fernández, Alba; Vivo-Llorca, Gema; Sancho, Mónica; García-Jareño, Alicia Belén; Ramírez-Jiménez, Laura; Barber-Cano, Eloísa; Murguía, Jose R.; Orzaez, Mar; Sancenón Galarza, Félix; Martínez-Máñez, Ramón(The Royal Society of Chemistry, 2022-07)
[EN] In this article, we report one of the few examples of nanoparticles capable of simultaneously delivering CRISPR-Cas9 gene-editing machinery and releasing drugs for one-shot treatments. Considering the complexity of ...
[EN] One appealing concept in the field of hybrid materials is related to the design of gated materials. These materials are prepared in such a way that the release of chemical or biochemical species from voids of porous ...
Lérida Viso, Araceli(Universitat Politècnica de València, 2023-07-06)
[ES] La presente tesis doctoral titulada "La terapia senolítica como nuevo enfoque terapéutico para la prevención de la cardiotoxicidad inducida por la doxorrubicina" se centra en explorar la eliminación de células senescentes ...