Aparici-Espert, Maria Isabel; Francés Monerris, Antonio; Rodríguez Muñiz, Gemma María; Roca Sanjuan, Daniel; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel(American Chemical Society, 2016-05-20)
The chemical fate of radical intermediates is relevant to understand the biological effects of radiation and to explain formation of DNA lesions. A direct approach to selectively generate the putative reactive intermediates ...
Lineros-Rosa, Mauricio; Francés-Monerris, Antonio; Monari, Antonio; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria(The Royal Society of Chemistry, 2020-11-28)
[EN] Interaction of nucleic acids with light is a scientific question of paramount relevance not only in the understanding of life functioning and evolution, but also in the insurgence of diseases such as malignant skin ...
Fraga-Timiraos, Ana Belén; Francés-Monerris, Antonio; Rodríguez Muñiz, Gemma María; Navarrete-Miguel, Miriam; Miranda Alonso, Miguel Ángel; Roca Sanjuan, Daniel; Lhiaubet, Virginie Lyria(John Wiley & Sons, 2018-10-12)
[EN] Azetidines are interesting compounds in medicine and chemistry as bioactive scaffolds and synthetic intermediates. However, photochemical processes involved in the generation and fate of azetidine-derived radical ions ...
Francés-Monerris, Antonio; Lineros-Rosa, Mauricio; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria; Monari, Antonio(The Royal Society of Chemistry, 2020-04-25)
[EN] The propensity of 5-formyluracil and 5-formylcytosine, i.e. oxidative lesions and epigenetic intermediates, in acting as intrinsic DNA photosensitizers is unraveled by using a combination of molecular modeling, ...
Navarrete-Miguel, Miriam; Francés-Monerris, Antonio; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria; Roca-Sanjuan, Daniel(MDPI AG, 2021-05)
[EN] Photocycloreversion plays a central role in the study of the repair of DNA lesions, reverting them into the original pyrimidine nucleobases. Particularly, among the proposed mechanisms for the repair of DNA (6-4) ...
Francés-Monerris, Antonio; Hognon, Cécilia; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria; Monari, Antonio(The Royal Society of Chemistry, 2018-10-28)
[EN] Nucleic acids are constantly exposed to external agents that can induce chemical and photochemical damage. In spite of the great advances achieved in the last years, some molecular mechanisms of DNA damage are not ...
Lineros-Rosa, Mauricio; Cuquerella Alabort, Maria Consuelo; Francés-Monerris, Antonio; Monari, Antonio; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria(The Royal Society of Chemistry, 2021-04-28)
[EN] Recently, sunscreen-based drug photocages have been introduced to provide UV protection to photoactive drugs, thus increasing their photosafety. Here, combined experimental and theoretical studies performed on a ...