Cantini, Marco; Rico Tortosa, Patricia María; Moratal Pérez, David; Salmerón Sánchez, Manuel(Royal Society of Chemistry, 2012)
Plasma polymerization was used to produce novel nanometric coatings able to direct fibronectin adsorption and cell response. Using ethyl acrylate as a monomer, we obtain coatings whose chemical composition maintains some ...
[EN] Fibronectin (FN) assembles into fibrillar networks by cells through an integrin-dependent mechanism. We have recently shown that simple FN adsorption onto poly(ethyl acrylate) surfaces (PEA), but not control polymer ...
[EN] We have engineered polymer-based microenvironments that promote vasculogenesis both in vitro and in vivo through synergistic integrin-growth factor receptor signalling. Poly(ethyl acrylate) (PEA) triggers spontaneous ...
Sprott, Mark Robert; Gallego-Ferrer, Gloria; Dalby, Matthew J.; Salmerón Sánchez, Manuel; Cantini, Marco(Wiley-VCH, 2019-02-07)
[EN] Poly-l-lactic acid (PLLA) has been used as a biodegradable polymer for many years; the key characteristics of this polymer make it a versatile and useful resource for regenerative medicine. However, it is not inherently ...
Cantini, Marco; Sousa, Maria; Moratal Pérez, David; Mano, Joao F.; Salmerón Sánchez, Manuel(Royal Society of Chemistry, 2013-02)
[EN] In this study, we propose a methodology to obtain a family of biomimetic substrates with a hierarchical rough topography at the micro and nanoscale that span the entire range of wettability, from the superhydrophobic ...
Cells assemble fibronectin (FN) into fibrils in a process mediated by integrins. For this process to occur, it is known that the presence of other serum proteins is necessary. However, the individual effect of these proteins ...
[EN] While much work has been done in the design of biomaterials to control integrin-mediated adhesion, less emphasis has been put on functionalization of materials with cadherin ligands. Yet, cell-cell contacts in combination ...