Martínez, Fernando; Carrasco, José L.; Toft, Christina; Hillung, Julia; Giménez-Santamarina, Silvia; Yenush, Lynne; Rodrigo Tarrega, Guillermo; ELENA FITO, SANTIAGO FCO(Springer Nature, 2023-01-11)
[EN] Viruses are obligate intracellular parasites that have co-evolved with their hosts to establish an intricate network of protein-protein interactions. Here, we followed a high-throughput yeast two-hybrid screening to ...
[EN] Hepatitis C virus (HCV) is highly variable and associated with chronic liver disease. Viral isolates are grouped into seven genotypes
(GTs). Accumulating evidence indicates that viral determinants in the core to NS2 ...
[EN] The RNA-dependent RNA polymerase (NS5B) of hepatitis C virus (HCV) is part of the viral replicative complex and plays a crucial role in HCV replication. It has been described that NS5B interacts with cellular proteins, ...
Hillung, Julia; Cuevas Torrijos, Jose Manuel; Valverde, Sergi; Elena Fito, Santiago Fco(Wiley, 2014-09)
[EN] This study evaluates the extent to which genetic differences among host individuals from the same species condition the evolution of a plant RNA virus. We performed a threefold replicated evolution experiment in which ...
Hillung, Julia; Elena Fito, Santiago Fco; Cuevas Torrijos, Jose Manuel(BioMed Central, 2013-11-13)
Background: Pipo was recently described as a new ORF encoded within the genome of the Potyviridae family members (PNAS 105: 5897-5902, 2008). It is embedded within the P3 cistron and is translated in the +2 reading frame ...
Hillung, Julia; Cuevas Torrijos, Jose Manuel; Elena Fito, Santiago Fco(Frontiers Media, 2012-06)
The use of high-throughput transcript profiling techniques has opened the possibility of
identifying, in a single experiment, multiple host mRNAs whose levels of accumulation are
altered in response to virus infection. ...