[EN] Background: Isoprenoids constitute a vast family of natural compounds performing diverse and essential functions in all domains of life. In most eubacteria, isoprenoids are synthesized through the methylerythritol ...
Carretero Paulet, Lorenzo; Fares Riaño, Mario Ali(Oxford University Press (OUP), 2012-11)
[EN] Gene duplicates are a major source of evolutionary novelties in the form of new or specialized functions and play a key role in speciation. Gene duplicates are generated through whole genome duplications (WGD) or ...
Carretero Paulet, Lorenzo; Albert, VA; Fares Riaño, Mario Ali(Oxford University Press (OUP), 2013-09)
[EN] The ubiquitous and conserved cytosolic heat-shock proteins 90 (HSP90A) perform essential functions in the cell. To understand the evolutionary origin of HSP90A functional diversification, we analyzed the distribution ...
Keane, O.M.; Toft, C.; Carretero Paulet, Lorenzo; Jones, G.W.; Fares Riaño, Mario Ali(Cold Spring Harbor Laboratory Press, 2014-11)
[EN] Biological systems remain robust against certain genetic and environmental challenges. Robustness allows the exploration of ecological adaptations. It is unclear what factors contribute to increasing robustness. Gene ...