De Diego Damiá, Alfredo; Cortijo Gimeno, Julio; Selma Ferrer, María José; León Fábregas, Montserrat; Almudéver-Folch, Patricia; Milara Payá, Javier(Elsevier, 2011-09)
[EN] Introduction: Cigarette smoke is the main cause of inflammation in COPD. The mechanisms that differentiate smokers who develop COPD are diverse. In this study, we analyzed the presence of cytokines in the
respiratory ...
[EN] Eosinophils play a prominent role in the process of allergic inflammation. Non-receptor associated Lyn tyrosine kinases generate key initial signals in eosinophils. Bafetinib, a specific Abl/Lyn tyrosine kinase inhibitor ...
[EN] Background and purpose: Pulmonary arteries from smokers and chronic obstructive pulmonary disease patients show abnormal endothelium-dependent vascular reactivity. We studied the effect of cigarette smoke extract (CSE) ...
Roger Laparra, Inés(Universitat Politècnica de València, 2016-09-08)
[EN] Chronic Obstructive Pulmonary Disease (COPD) is characterized by a progressive limitation of the airflow that is not fully reversible. In North America, between three and seven million people are diagnosed with COPD ...
Hernández Ribes, Gracia(Universitat Politècnica de València, 2016-05-16)
[EN] Idiopathic pulmonary fibrosis (IPF) is the pulmonary disease with higher incidence and worse prognosis. Recent evidence suggests that cucurbitaceae, selective inhibitors of the JAK2/STAT3 pathway, may improve the ...
[EN] Background Oxidative stress is present in airway diseases such as severe asthma or Chronic Obstructive Pulmonary Disease and contributes to the low response to glucocorticoids through the down-regulation of histone ...
Morell Garcia, Anselm(Universitat Politècnica de València, 2015-07-01)
[EN] Chronic Rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory disease of the nasal mucosa and upper airways. The main treatment of CRSwNP with topic or oral corticosteroids presents a degree of resistance and ...
Ballester Llobell, Beatriz(Universitat Politècnica de València, 2016-05-03)
[EN] Idiopathic Pulmonary Fibrosis (IPF) is a chronic progressive lung disease of unknown etiology, with a life expectancy of 2-5 years since first diagnosis. A proportion of patients with IPF develop pulmonary hypertension ...
Montero Magalló, Paula(Universitat Politècnica de València, 2016-09-07)
[ES] La fibrosis pulmonar idiopática es una enfermedad pulmonar intersticial que afecta alrededor de 500000 personas en Europa. Se trata de una enfermedad pulmonar fibrótica que cursa con disnea, disminución de la función ...
Pérez Leal, Martín(Universitat Politècnica de València, 2015-09-08)
[ES] Con este trabajo se pretende poner a punto en el laboratorio un modelo "in vivo" de aclaramiento mucociliar mediante tomografía computerizada de emisión monofotónica (SPECT) en cobaya para su uso en ensayos farmacologicos ...
Rius Rocabert, Sergio(Universitat Politècnica de València, 2015-01-19)
[ES] La rinosinusitis es un proceso inflamatorio que afecta a la cavidad y senos nasales obstruyéndolos. Se denomina rinosinusitis crónica (RSC) cuando la enfermedad perdura más allá de las 12 semanas. La RSC puede verse ...
[EN] Background Pulmonary hypertension in idiopathic pulmonary fibrosis (IPF) is indicative of a poor prognosis. Recent evidence suggests that tetrahydrobiopterin (BH4), the cofactor of nitric oxide synthase (NOS), is ...