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Listar por autor "Merino Sanjuán, María Matilde"

Mostrando ítems 1-5 de 5

Assessment of the Inter-Batch Variability of Microstructure Parameters in Topical Semisolids and Impact on the Demonstration of Equivalence

Mangas-Sanjuan, Victor; Pleguezuelos-Villa, María; Merino-Sanjuán, Matilde; Hernández, Mª Jesús; Nácher, Amparo; García-Arieta, Alfredo; Peris, Daniel; Hidalgo, Irene; Soler, Lluís; Sallan, Marta; Merino, Virginia (MDPI AG, 2019-10)

[EN] Demonstration of similar microstructure is essential for demonstrating the equivalence of generic topical products since the microstructure of semisolids may affect the drug release. The objective of this study was ...
Bioequivalence risk assessment of oral formulations containing racemic ibuprofen through a chiral physiologically based pharmacokinetic model of ibuprofen enantiomers

Reig-López, Javier; M. Cuquerella-Gilabert; Bandín-Vilar, Enrique; Merino-Sanjuán, Matilde; Mangas-Sanjuán, Victor; García-Arieta, Alfredo (Elsevier, 2024-06)

[EN] The characterization of the time course of ibuprofen enantiomers can be useful in the selection of the most sensitive analyte in bioequivalence studies. Physiologically based pharmacokinetic (PBPK) modelling and ...
Enzyme-Responsive Silica Mesoporous Supports Capped with Azopyridinium Salts for Controlled Delivery Applications

Mas Font, Nuria; Agostini, Alessandro; Mondragón Martínez, Laura; Bernardos Bau, Andrea; Sancenón Galarza, Félix; Marcos Martínez, María Dolores; Martínez Mañez, Ramón; Costero Nieto, Ana María; Gil Grau, Salvador; Merino Sanjuán, María Matilde; Amoros del Toro, Pedro Jose; Orzáez Calatayud, Mar; Pérez Payá, Enrique (Wiley-VCH Verlag, 2012-12-07)

The preparation of a new capped silica mesoporous material, Rh-Azo-S, for on-command delivery applications in the presence of target enzymes is described. The material consists of nanometric mesoporous MCM-41-like supports ...
Influence of Inter- and Intra-Batch Variability on the Sample Size Required for Demonstration of Equivalent Microstructure of Semisolid Dosage Forms

Xu, Zhengguo; Mangas-Sanjuan, Victor; Merino-Sanjuán, Matilde; Merino, Virginia; García-Arieta, Alfredo (MDPI AG, 2020-12)

[EN] Inter- and intra-batch variability of the quality attributes contribute to the uncertainty for demonstrating equivalent microstructure of post-approval changes and generic/hybrids of semisolid topical products. Selecting ...
Investigation of Different Iontophoretic Currents Profiles for Short-Term Applications in Cosmetics

Cázares-Delgadillo, J.; Planard-Luong, L.; Gregoire, S.; Serna-Jiménez, C. E.; Singhal, Mayank; Kalia, Yogeshvar N.; Merino Sanjuán, Virginia; Merino sanjuán, Matilde; Nacher Alonso, Amparo; Martinez-Gomez, M. A.; Burnier-Yalaoui, V.; Barbarat, P. (MDPI AG, 2018)

[EN] This study aimed at investigating the effect of electrical current profile upon the iontophoretic transport of (i) ascorbic acid (AA) and (ii) ellagic acid (EA), into porcine skin in vitro, and the impact of the ...