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Listar por autor "Cano García, Jordi"

Mostrando ítems 1-8 de 8

APD, QT interval and Tx Values

Saiz Rodríguez, Francisco Javier; Sanz i Carreras, Ferran; Pastor Maeso, Manuel; Trénor Gomis, Beatriz Ana; Gomis-Tena Dolz, Julio; Cano García, Jordi; Romero Pérez, Lucia (Universitat Politècnica de València, 2017-10-31)

This repository contains four Excel 2017 files named “APD.xlsx”, “QT.xlsx”, “Tx_APD.xlsx” and “Tx_QT.xlsx”. APD.xlsx and Tx_APD.xlsx files contain three sheets (called “Epi”, “Mid” and “Endo”), whereas the rest contain ...
Aplicación de modelos computacionales multiescala de la actividad eléctrica en la predicción de cardiotoxicidad

Cano García, Jordi (Universitat Politècnica de València, 2015-06-17)

[EN] Introduction. In the risk prediction of Torsade-de-pointes arrythmia assotiated to drug intake, electric conduction multiscale models are used but, for now, a connection between dose, plasma concentration and channel ...
Desarrollo de modelos personalizados de ventrículos y torso de pacientes pediátricos

González Llácer, Ignacio (Universitat Politècnica de València, 2021-10-08)

[ES] El presente trabajo de investigación de Final de Máster centra su estudio en el ámbito del modelado y la simulación bioeléctrica, concretamente en el desarrollo de modelos cardíacos tridimensionales para pacientes ...
InSilico Classifiers for the Assessment of Drug Proarrhythmicity

Llopis-Lorente, Jordi; Gomis-Tena Dolz, Julio; Cano, Jordi; Romero Pérez, Lucia; Saiz Rodríguez, Francisco Javier; Trenor Gomis, Beatriz Ana (American Chemical Society, 2020-10-26)

[EN] Drug-induced torsade de pointes (TdP) is a life-threatening ventricular arrhythmia responsible for the withdrawal of many drugs from the market. Although currently used TdP risk-assessment methods are effective, they ...
Prediction of the effects of drugs on cardiac activity using computer simulations

Cano García, Jordi (Universitat Politècnica de València, 2021-03-22)

[ES] Las enfermedades cardiovasculares siguen siendo la principal causa de muerte en Europa. Las arritmias cardíacas son una causa importante de muerte súbita, pero sus mecanismos son complejos. Esto denota la importancia ...
Ranolazine as an Alternative Therapy to Flecainide for SCN5A V411M Long QT Syndrome Type 3 Patients

Cano, Jordi; Zorio, Esther; Mazzanti, Andrea; Arnau, Miguel Ángel; Trenor Gomis, Beatriz Ana; Priori, Silvia G.; Saiz Rodríguez, Francisco Javier; Romero Pérez, Lucia (Frontiers Media SA, 2020-12-17)

[EN] The prolongation of the QT interval represents the main feature of the long QT syndrome (LQTS), a life-threatening genetic disease. The heterozygous SCN5A V411M mutation of the human sodium channel leads to a LQTS ...
Tx, TqNet and Ttriang Values

Llopis Lorente, Jordi; Gomis-Tena Dolz, Julio; Cano García, Jordi; Romero Pérez, Lucia; Saiz Rodríguez, Francisco Javier; Trénor Gomis, Beatriz Ana (Universitat Politècnica de València, 2020-02-14)

This repository contains the Matlab functions used in [1] and six Excel files named “Tx matrix KrKsCaL.xlsx”, “Tx matix KrNaLCaL.xlsx”, “TqNet matrix KrKsCaL.xlsx”, “TqNet matrix KrNaLCaL.xlsx”, "Ttirang matrix KrKsCaL.xlsx" ...
When Does the IC50 Accurately Assess the Blocking Potency of a Drug?

Gomis-Tena Dolz, Julio; Brown, Brandon M.; Cano, Jordi; Trenor Gomis, Beatriz Ana; Yang, Pei-Chi; Saiz Rodríguez, Francisco Javier; Clancy, Colleen E.; Romero Pérez, Lucia (American Chemical Society, 2020-03-23)

[EN] Preclinical assessment of drug-induced proarrhythmicity is typically evaluated by the potency of the drug to block the potassium human ether-a-go-go-related gene (hERG) channels, which is currently quantified by the ...