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Listar por autor "Tamarit Mayo, Lorena"

Mostrando ítems 1-9 de 9

Cellular photo(geno)toxicity of gefitinib after biotransformation

El Ouardi, Meryem; Tamarit-Mayo, Lorena; Vayá Pérez, Ignacio; Miranda, Miguel A.; Andreu, Inmaculada (Frontiers Media SA, 2023-06-07)

[EN] Gefitinib (GFT) is a selective epidermal growth factor receptor (EGFR) inhibitor clinically used for the treatment of patients with non-small cell lung cancer. Bioactivation by mainly Phase I hepatic metabolism leads ...
Diseño de nanopartículas de oro funcionalizadas con AINEs y proteínas para su uso en biomedicina

Tamarit Mayo, Lorena (Universitat Politècnica de València, 2018-10-11)

[ES] En este trabajo se han diseñado una serie de nanopartículas de oro (AuNPs) esféricas funcionalizadas con fármacos (antiinflamatorios no esteroideos, AINEs) con la finalidad de realizar un estudio fotofísico completo ...
Fotorreactividad de gefitinib y sus metabolitos fenólicos en disolución y en proteínas transportadoras.

Tamarit Mayo, Lorena (Universitat Politècnica de València, 2024-05-13)

[ES] Los inhibidores de la tirosina quinasa (TKIs) son fármacos anticancerígenos que actúan atacando selectivamente a las células cancerosas, inhibiendo su crecimiento descontrolado y, por tanto, la consiguiente aparición ...
Modulation of the photobehavior of gefitinib and its phenolic metabolites by human transport proteins

Tamarit-Mayo, Lorena; El Ouardi, Meryem; Lence, Emilio; Andreu, Inmaculada; González-Bello, Concepción; Miranda Alonso, Miguel Ángel; Vayá Pérez, Ignacio (Frontiers Media SA, 2024-05-16)

[EN] The photobiological damage that certain drugs or their metabolites can photosensitize in proteins is generally associated with the nature of the excited species that are generated upon interaction with UVA light. In ...
Photolytic splitting of homodimeric quinone-derived oxetanes studied by ultrafast transient absorption spectroscopy and quantum chemistry

Blasco-Brusola, Alejandro; Tamarit-Mayo, Lorena; Navarrete-Miguel, Miriam; Roca-Sanjuán, Daniel; Miranda, Miguel A.; Vayá Pérez, Ignacio (The Royal Society of Chemistry, 2024-05-01)

[EN] The photoinduced cycloreversion of oxetane derivatives is of considerable biological interest since these compounds are involved in the photochemical formation and repair of the highly mutagenic pyrimidine (6-4) ...
Photoprocesses of the tyrosine kinase inhibitor gefitinib: from femtoseconds to microseconds and from solution to the cell

Tamarit-Mayo, Lorena; El Ouardi, Meryem; Andreu Ros, María Inmaculada; Vayá Pérez, Ignacio; Miranda Alonso, Miguel Ángel (The Royal Society of Chemistry, 2021-09-28)

[EN] Gefitinib (GFT) is a tyrosine kinase inhibitor currently used for the treatment of metastatic non-small cell lung cancer. Although it has been suggested that GFT can be phototoxic, there are no systematic studies on ...
Sistemas fotoactivos para estudios de viabilidad celular con células cancerosas SKBr-3

Belda Marqués, Núria (Universitat Politècnica de València, 2021-10-06)

[ES] En este trabajo de fin de grado se han sintetizado nanopartículas esféricas de oro (AuNPs) con un diámetro de 2-4 nm, las cuales han sido funcionalizadas con polietilenglicol (PEG), diferentes proteínas (HSA, BSA, ...
Switching from ultrafast electron transfer to proton transfer in excited drug-protein complexes upon biotransformation

Tamarit-Mayo, Lorena; El Ouardi, Meryem; Lence, Emilio; Andreu, Inmaculada; González-Bello, Concepción; Vayá Pérez, Ignacio; Miranda Alonso, Miguel Ángel (The Royal Society of Chemistry, 2022-08-24)

[EN] Photosensitization by drugs is directly related with the excited species and the photoinduced processes arising from interaction with UVA light. In this context, the ability of gefitinib (GFT), a tyrosine kinase ...
Topological effects in ultrafast photoinduced processes between flurbiprofen and tryptophan in linked dyads and within human serum albumin

Tamarit-Mayo, Lorena; García-Gabarda, Laura; Jiménez, M Consuelo; Miranda, Miguel A.; Vayá Pérez, Ignacio (The Royal Society of Chemistry, 2023-06-15)

[EN] The interaction dynamics between flurbiprofen (FBP) and tryptophan (Trp) has been studied in covalently linked dyads and within human serum albumin (HSA) by means of fluorescence and ultrafast transient absorption ...