González-Cardenete, Miguel A; Rivas, Fatima; Basset, Rachel; Stadler, Marco; Hering, Steffen; Padrón, José M.; Zaragozá, Ramón J.; Dea-Ayuela, Maria Auxiliadora(MDPI AG, 2021-02)
[EN] The abietane-type diterpenoids are significant bioactive compounds exhibiting a varied range of pharmacological properties. In this study, the first synthesis and biological investigation of the new abietane-diterpenoid ...
Arrighi, Giulia; Puerta, Adrián; Petrini, Andrea; Hicke-García, Francisco Javier; Nocentini, Alessio; Fernandes, Miguel X.; Padrón, José M.; Supuran, Claudiu T.; Fernández-Bolaños, José G.; López, Óscar(MDPI AG, 2022-07)
[EN] (1) Background: carbonic anhydrases (CAs) are attractive targets for the development of new anticancer therapies; in particular, CAs IX and XII isoforms are overexpressed in numerous tumors. (2) Methods: following the ...
Hicke-García, Francisco Javier; Puerta, Adrián; Dinic, Jelena; Pesic, Milica; Padrón, José M.; López, Óscar; Fernández-Bolaños, José G.(Elsevier, 2022-01-15)
[EN] The necessity for developing novel cytostatic agents with improved activities and reduced side-effects to
tackle cancer prompted us to investigate mitochondria-targeted compounds, an approach that is gaining
attention ...