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Listar por autor "Aparici Espert, María Isabel"

Mostrando ítems 1-6 de 6

A Combined Experimental and Theoretical Approach to the Photogeneration of 5,6-Dihydropyrimidin-5-yl Radicals in Nonaqueous Media

Aparici-Espert, Maria Isabel; Francés Monerris, Antonio; Rodríguez Muñiz, Gemma María; Roca Sanjuan, Daniel; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel (American Chemical Society, 2016-05-20)

The chemical fate of radical intermediates is relevant to understand the biological effects of radiation and to explain formation of DNA lesions. A direct approach to selectively generate the putative reactive intermediates ...
Enhanced Drug Photosafety by Interchromophoric Interaction Due to Intramolecular Charge Separation

Li, Ming-De; Yan, Zhiping; Zhu, Ruixue; Phillips,David Lee; Aparici-Espert, Maria Isabel; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel (John Wiley & Sons, 2018-05-02)

[EN] Imatinib is a synthetic tyrosinase inhibitor that is employed for the treatment of some kinds of human cancer. This drug has a low phototoxicity towards DNA, but its pyridylpyrimidine (1) fragment by itself exhibits ...
Oxidatively Generated Lesions as Internal Photosensitizers for Pyrimidine Dimerization in DNA

Aparici-Espert, Maria Isabel; García-Laínez, G.; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria (American Chemical Society, 2018-03)

[EN] In this work, the attention is focused on UVA-photosensitized reactions triggered by a DNA chromophore-containing lesion, namely 5-formyluracil. This is a major oxidatively generated lesion that exhibits an enhanced ...
Photocages for protection and controlled release of bioactive compounds

Aparici-Espert, Maria Isabel; Cuquerella Alabort, Maria Consuelo; Paris, Cecilia; Lhiaubet ., Virginie Lyria; Miranda Alonso, Miguel Ángel (The Royal Society of Chemistry, 2016)

[EN] Using a sunscreen-based photocage, we have demonstrated that it is possible to prevent photodegradation of a bioactive compound and to achieve its controlled photorelease. The concept has been proven linking avobenzone, ...
Photochemistry of 1,3-Dicarbonyl Compounds: DNA Photodamage vs. Photoprotection

Aparici Espert, María Isabel (Universitat Politècnica de València, 2018-07-13)

El objetivo principal de esta tesis es contrastar el papel de dichos compuestos 1,3-dicarbonilicos como agentes que dañan el ADN con respecto a su potencial fotoprotector. Primero, 5,6-dihidropirimidinas han sido ...
Sunscreen-Based Photocages for Topical Drugs: A Photophysical and Photochemical Study of A Diclofenac-Avobenzone Dyad

Aparici-Espert, Maria Isabel; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria (MDPI AG, 2018-03)

[EN] Photosensitization by drugs is a problem of increasing importance in modern life. This phenomenon occurs when a chemical substance in the skin is exposed to sunlight. Photosensitizing drugs are reported to cause severe ...