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Listar por autor "Llopis Lorente, Jordi"

Mostrando ítems 1-14 de 14

Análisis comparativo del efecto farmacológico en células ventriculares sanas y con insuficiencia cardíaca mediante métodos de modelado y simulación

Llopis Lorente, Jordi (Universitat Politècnica de València, 2018-10-10)

[ES] Uno de los posibles efectos secundarios de un fármaco es la generación de Torsade de Pointes (TdP), una taquicardia ventricular potencialmente letal, responsable de la retirada de muchos fármacos del mercado. Por ello, ...
Application of Machine Learning to improve the efficiency of electrophysiological simulations used for the prediction of drug-induced ventricular arrhythmia

Rodriguez-Belenguer, Pablo; Kopanska, Karolina; Llopis-Lorente, Jordi; Trenor Gomis, Beatriz Ana; Saiz Rodríguez, Francisco Javier; Pastor, Manuel (Elsevier, 2023-03)

[EN] Background and Objective In silico prediction of drug-induced ventricular arrhythmia often requires computationally intensive simulations, making its application tedious and non-interactive. This inconvenience can ...
Application of Machine Learning to improve the efficiency of electrophysiological simulations used for the prediction of drug-induced ventricular arrhythmia

Rodríguez-Belenguer, Pablo; Kopańska, Karolina; Llopis Lorente, Jordi; Trénor Gomis, Beatriz Ana; Saiz Rodríguez, Francisco Javier; Pastor, Manuel (Universitat Politècnica de València, 2022-06-03)

In cardiotoxicity studies it is common to pre-compute the values of different biomarkers (my equation or TX) for a range of ion channel blockades. Since every simulation requires costly computations, to complete the matrix ...
Combining pharmacokinetic and electrophysiological models for early prediction of drug-induced arrhythmogenicity

Llopis-Lorente, Jordi; Baroudi, Samuel; Koloskoff, Kévin; Mora-Fenoll, María Teresa; Basset, Matthieu; Romero Pérez, Lucia; Benito, Sylvain; Dayan, Frederic; Saiz Rodríguez, Francisco Javier; Trenor Gomis, Beatriz Ana (Elsevier, 2023-12)

[EN] Background and Objective: In silico methods are gaining attention for predicting drug-induced Torsade de Pointes (TdP) in different stages of drug development. However, many computational models tended not to account ...
Combining pharmacokinetic and electrophysiological models for early prediction of drug-induced arrhythmogenicity

Llopis-Lorente, Jordi; Baroudi, Samuel; Koloskoff, Kévin; Romero Pérez, Lucia; Mora-Fenoll, María Teresa; Basset, Matthieu; Benito, Sylvain; Dayan, Frederic; Saiz Rodríguez, Francisco Javier; Trénor Gomis, Beatriz Ana (Universitat Politècnica de València, 2023-03-29)

This repository contains the code used to generate the male and female population of models and simulate the different pharmacokinetic scenarios in Llopis-Lorente et al. (2023). Combining pharmacokinetic and electrophysiological ...
Considering population variability of electrophysiological models improves the assessment of drug-induced torsadogenic risk

Llopis-Lorente, Jordi; Trenor Gomis, Beatriz Ana; Saiz Rodríguez, Francisco Javier (Elsevier, 2022-06)

[EN] Background and Objective In silico tools are known to aid in drug cardiotoxicity assessment. However, computational models do not usually consider electrophysiological variability, which may be crucial when predicting ...
Considering Population Variability of Electrophysiological Models Improves the In Silico Assessment of Drug-Induced Torsadogenic Risk

Llopis Lorente, Jordi; Trénor Gomis, Beatriz Ana; Saiz Rodríguez, Francisco Javier (2022-05-13)

This repository contains the parameter sets of the population of TorORd models and the the population of ORdmD models, the ORdmD CellML file and MALTAB code used in Llopis-Lorente, J., Trenor, B., Saiz, J. (2022). Considering ...
Estudio comparativo del efecto farmacológico en poblaciones de células ventriculares sanas y patológicas mediante modelado y simulación

Scals Carmona, Sara de (Universitat Politècnica de València, 2021-07-28)

[ES] La Torsade de Pointes es una taquiarritmia ventricular responsable de la retirada de ciertos fármacos del mercado por ser uno de los efectos adversos más graves. Para reducir su incidencia, han surgido iniciativas ...
Estudio del efecto farmacológico en poblaciones de células ventriculares sanas de hombres y mujeres mediante modelado y simulación

Ballester López, Ignacio (Universitat Politècnica de València, 2022-09-07)

[ES] La Torsade de Pointes (TdP) es un tipo de arritmia ventricular potencialmente mortal que puede aparecer como efecto secundario tras la toma de un fármaco. La TdP es responsable de que muchos fármacos no puedan llegar ...
Impact of Epicardial Adipose Tissue on Infarct Size and Left Ventricular Systolic Function in Patients with Anterior ST-Segment Elevation Myocardial Infarction

Gavara-Doñate, Josep; Merenciano-Gonzalez, Héctor; Llopis-Lorente, Jordi; Molina-García, Tamara; Perez-Solé, Nerea; De Dios, Elena; Marcos-Garces, Víctor; Monmeneu, José V.; Lopez-Lereu, Maria P.; Cànoves, Joaquim; Clara Bonanad; Moratal, David; Nuñez, Julio; Bayés-Genis, Antoni; Sanchis, Juan (MDPI AG, 2024-02)

[EN] We aimed to assess the correlation of cardiovascular magnetic resonance (CMR)-derived epicardial adipose tissue (EAT) with infarct size (IS) and residual systolic function in ST-segment elevation myocardial infarction ...
InSilico Classifiers for the Assessment of Drug Proarrhythmicity

Llopis-Lorente, Jordi; Gomis-Tena Dolz, Julio; Cano, Jordi; Romero Pérez, Lucia; Saiz Rodríguez, Francisco Javier; Trenor Gomis, Beatriz Ana (American Chemical Society, 2020-10-26)

[EN] Drug-induced torsade de pointes (TdP) is a life-threatening ventricular arrhythmia responsible for the withdrawal of many drugs from the market. Although currently used TdP risk-assessment methods are effective, they ...
Tx, TqNet and Ttriang Values

Llopis Lorente, Jordi; Gomis-Tena Dolz, Julio; Cano García, Jordi; Romero Pérez, Lucia; Saiz Rodríguez, Francisco Javier; Trénor Gomis, Beatriz Ana (Universitat Politècnica de València, 2020-02-14)

This repository contains the Matlab functions used in [1] and six Excel files named “Tx matrix KrKsCaL.xlsx”, “Tx matix KrNaLCaL.xlsx”, “TqNet matrix KrKsCaL.xlsx”, “TqNet matrix KrNaLCaL.xlsx”, "Ttirang matrix KrKsCaL.xlsx" ...
Uncertainty assessment of proarrhythmia predictions derived from multi-level in silico models

Kopanska, Karolina; Rodriguez-Belenguer, Pablo; Llopis-Lorente, Jordi; Trenor Gomis, Beatriz Ana; Saiz Rodríguez, Francisco Javier; Pastor, Manuel (Springer-Verlag, 2023-08-01)

[EN] In silico methods can be used for an early assessment of arrhythmogenic properties of drug candidates. However, their use for decision-making is conditioned by the possibility to estimate the predictions' uncertainty. ...
Uncertainty Assessment of Proarrhythmia Predictions Derived from Multi-Level in Silico Models

Kopanska, Karolina; Rodríguez-Belenguer, Pablo; Llopis-Lorente, Jordi; Trénor, Beatriz; Saiz, Javier; Pastor, Manuel (Universitat Politècnica de València, 2023-02-14)

[EN] These datasets were generated to train ("PopulationDrugsTrainingKrNaLCaL.xlsx") and test ("PopulationDrugsTestKrCaLNaL.xlsx") the uncertainty assessment models developed in the paper "Uncertainty assessment of ...