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Listar por autor "Blandez Barradas, Juan Francisco"

Mostrando ítems 1-20 de 27

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A Nanoprobe Based on Gated Mesoporous Silica Nanoparticles for The Selective and Sensitive Detection of Benzene Metabolite t,t-Muconic Acid in Urine

Domínguez-Rodríguez, Marcia; Blandez, Juan F.; Lozano-Torres, Beatriz; De La Torre-Paredes, Cristina; Licchelli, Maurizio; Mangano, Carlo; Amendola, Valeria; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (John Wiley & Sons, 2021-01-18)

[EN] Benzene is a highly toxic aromatic hydrocarbon. Inhaling benzene can cause dizziness, vertigo, headaches, aplasia, mutations and, in the most extreme cases, cancer. Trans,trans-muconic acid (t,t-MA) is one of the ...
A NIR fluorescent probe for the detection of renal damage based on overrepresentation of alanine aminopeptidase enzyme

Domínguez-Rodríguez, Marcia; Meyer, Kathleen; Sancenón Galarza, Félix; Blandez, Juan F.; Serrano, Manuel; Martínez-Máñez, Ramón (The Royal Society of Chemistry, 2023-02-23)

[EN] Kidney damage generates changes at the phenotypic and genotypic levels that allow its monitoring using different biomarkers in blood, urine or serum. Among these biomarkers, kidney failure causes the urine overrepresentation ...
A renal clearable fluorogenic probe for in vivo ß-galactosidase activity detection during aging and senolysis

Rojas-Vázquez, Sara; Lozano-Torres, Beatriz; García-Fernández, Alba; Galiana, Irene; Perez-Villalba, Ana; Martí-Rodrigo, Pablo; Palop, M. José; Domínguez, Marcia; Orzaez, Mar; Sancenón Galarza, Félix; Blandez, Juan F.; Fariñas, Isabel; Martínez-Máñez, Ramón (Nature Publishing Group, 2024-01-26)

[EN] Accumulation of senescent cells with age leads to tissue dysfunction and related diseases. Their detection in vivo still constitutes a challenge in aging research. We describe the generation of a fluorogenic probe ...
A Two-Photon Probe Based on Naphthalimide-Styrene Fluorophore for the In Vivo Tracking of Cellular Senescence

Lozano-Torres, Beatriz; Blandez, Juan F.; Galiana, Irene; Lopez-Dominguez, Jose Alberto; Rovira, Miguel; Páez-Ribes, Marta; González-Gualda, Estela; Muñoz-Espín, Daniel; Serrano, Manuel; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (American Chemical Society, 2021-02-09)

[EN] Cellular senescence is a state of stable cell cycle arrest that can negatively affect the regenerative capacities of tissues and can contribute to inflammation and the progression of various aging-related diseases. ...
B-Galactosidase-Activatable Nile Blue-Based NIR Senoprobe for the Real-Time Detection of Cellular Senescence

Lozano-Torres, Beatriz; García-Fernández, Alba; Domínguez-Rodríguez, Marcia; Sancenón Galarza, Félix; Blandez, Juan F.; Martínez-Máñez, Ramón (American Chemical Society, 2023-01-17)

[EN] Cellular senescence is a stable cell cycle arrest in response to stress or other damage stimuli to maintain tissue homeostasis. However, the accumulation of senescent cells can lead to the progression of various ...
Chromo-fluorogenic probes for beta-galactosidase detection

Lozano-Torres, Beatriz; Blandez, Juan F.; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (Springer-Verlag, 2021-02-19)

[EN] beta-Galactosidase (beta-Gal) is a widely used enzyme as a reporter gene in the field of molecular biology which hydrolyzes the beta-galactosides into monosaccharides. beta-Gal is an essential enzyme in humans and its ...
Combination of palbociclib with navitoclax based-therapies enhances in vivo antitumoral activity in triple-negative breast cancer

Estepa-Fernández, Alejandra; García-Fernández, Alba; Lerida-Viso, Araceli; Blandez, Juan F.; Galiana, Irene; Sancenón Galarza, Félix; Orzaez, Mar; Martínez-Máñez, Ramón (Elsevier, 2023-01)

[EN] Triple-negative breast cancer (TNBC) is a very aggressive subtype of breast cancer with a poor prognosis and limited effective therapeutic options. Induction of senescence, arrest of cell proliferation, has been ...
Copper Nanoparticles Supported on Doped Graphenes as Catalyst for the Dehydrogenative Coupling of Silanes and Alcohols

Blandez Barradas, Juan Francisco; Primo Arnau, Ana María; Asiri, Abdullah; Alvaro Rodríguez, Maria Mercedes; García Gómez, Hermenegildo (Wiley-VCH Verlag, 2014-11-10)

[EN] Copper nanoparticles (NPs) supported on a series of undoped and doped graphene materials (Gs) have been obtained by pyrolysis of alginate or chitosan biopolymers, modified or not with boric acid, containing Cu2+ ...
Delivery of miR-200c-3p Using Tumor-Targeted Mesoporous Silica Nanoparticles for Breast Cancer Therapy

Garrido-Cano, Iris; Adam-Artigues, Anna; Lameirinhas, Ana; Blandez, Juan F.; Candela-Noguera, Vicente; Lluch, Ana; Bermejo, Begoña; Sancenón Galarza, Félix; Cejalvo, Juan Miguel; Martínez-Máñez, Ramón; Eroles, Pilar (American Chemical Society, 2023-08)

[EN] Despite advancesin breast cancer treatment, it remainsthe leadingcause of cancer-related death in women worldwide. In this context,microRNAs have emerged as potential therapeutic targets but stillpresent some limitations ...
Desarrollo de una sonda molecular basada en el fluoróforo Azul de Nilo para la detección de células senescentes en modelos in vivo

Vivens Sanchis, Rosa (Universitat Politècnica de València, 2021-07-30)

[ES] La senescencia celular es un proceso que sufren las células mitóticamente competentes mediante el cual se produce el arresto del ciclo celular, y que puede ser activado de forma natural o inducida como respuesta al ...
Development of Smart Devices for the Detection of Metabolites of Toxic Substances and Disease-Related Enzyme Overexpression

Domínguez Rodríguez, Marcia (Universitat Politècnica de València, 2024-01-18)

[ES] Esta tesis se enfoca en el desarrollo de dispositivos inteligentes para detectar metabolitos de sustancias tóxicas y la sobreexpresión enzimática relacionada con enfermedades. Se aborda la limitación de las técnicas ...
Diseño de una instalación dedicada al proceso de obtención de 5kg del material mesoporoso MCM-41 mediante síntesis

Moreno Reolid, Pablo (Universitat Politècnica de València, 2022-10-13)

[ES] El presente trabajo está dedicado al estudio del proceso de síntesis del material mesoporoso MCM-41, comúnmente utilizado para la adsorción de moléculas orgánicas, catálisis y la encapsulación de fármacos en el ámbito ...
Electro-responsive films containing voltage responsive gated mesoporous silica nanoparticles grafted onto PEDOT-based conducting polymer

García-Fernández, Alba; Lozano-Torres, Beatriz; Blandez, Juan F.; Monreal-Trigo, Javier; Soto Camino, Juan; Collazos-Castro, Jorge E.; Alcañiz Fillol, Miguel; Marcos Martínez, María Dolores; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (Elsevier, 2020-07-10)

[EN] The characteristics and electromechanical properties of conductive polymers together to their biocompatibility have boosted their application as a suitable tool in regenerative medicine and tissue engineering. ...
Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

González-Gualda, Estela; Pàez-Rives, Marta; Lozano-Torres, Beatriz; Macias, David; Wilson III, Joseph R.; González-López, Cristina; Ou, Hui-Ling; MIrón-Barroso, Sofía; Zhang, Zhenguang; Lérida-Viso, Araceli; Blandez, Juan F.; Bernardos Bau, Andrea; Sancenón Galarza, Félix; Rovira, Miguel; Fruk, Ljiljana; Martins, Carla P.; Serrano, Manuel; Doherty, Gary J.; Martínez-Máñez, Ramón; Muñoz-Espín, Daniel (Blackwell Publishing, 2020-04)

[EN] Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse ...
Grafeno y materiales derivados como catalizadores seudohomogéneos en reacciones orgánicas

Blandez Barradas, Juan Francisco (Universitat Politècnica de València, 2017-06-13)

The present Doctoral Thesis is based on previous works reported by the research group of my supervisors. These works deals with the preparation of graphenic materials with or without heteroatoms derived from the pyrolysis ...
Graphenes as Metal-free Catalysts for the Oxidative Depolymerization of Lignin Models

Blandez Barradas, Juan Francisco; Navalón Oltra, Sergio; Alvaro Rodríguez, Maria Mercedes; García Gómez, Hermenegildo (Wiley, 2015-09-14)

Graphene oxide promotes the oxidative degradation of -guaiacylglycerol--guaiacyl ether, a lignin model compound, in different solvents including acetonitrile, toluene and water mainly to guaiacol, 2-methoxyquinone, vanillic ...
High catalytic activity of oriented 2.0.0 copper(I) oxide grown on graphene film

Primo Arnau, Ana María; Esteve Adell, Iván; Blandez Barradas, Juan Francisco; Amarajothi, Dhakshinamoorthy; Alvaro Rodríguez, Maria Mercedes; Candu, Natalia; Coman, Simona M.; Parvulescu, Vasile I.; García Gómez, Hermenegildo (Nature Publishing Group, 2015-10)

[EN] Metal oxide nanoparticles supported on graphene exhibit high catalytic activity for oxidation, reduction and coupling reactions. Here we show that pyrolysis at 900 C under inert atmosphere of copper(II) nitrate ...
Influence of functionalization of terephthalate linker on the catalytic activity of UiO-66 for epoxide ring opening

Blandez, Juan F.; Santiago-Portillo, Andrea; Navalón Oltra, Sergio; Gimenez Marques, Monica; Alvaro Rodríguez, Maria Mercedes; Horcajada, Patricia; García Gómez, Hermenegildo (Elsevier, 2016-12-15)

[EN] A series of five isostructural zirconium terephthalate UiO-66 metal organic frameworks bearing different functional groups on the terephthalate linker (UiO-66-X; X = H, NH2, NO2, Br, Cl,) have been successfully prepared ...
Influence of the organic linker substituent on the catalytic activity of MIL-101(Cr) for the oxidative coupling of benzylamines to imines

Santiago-Portillo, Andrea; Blandez, Juan F.; Navalón Oltra, Sergio; Alvaro Rodríguez, Maria Mercedes; García Gómez, Hermenegildo (The Royal Society of Chemistry, 2017)

[EN] MIL-101(Cr) having substituents at the terephthalate linker (X = H, NO2, SO3H, Cl, CH3 and NH2) promotes the aerobic oxidation of benzylamines to the corresponding N-benzylidene benzylamines at different rates. ...
Lipofuscin labeling through biorthogonal strain-promoted azide-alkyne cycloaddition for the detection of senescent cells

Lozano-Torres, Beatriz; Blandez, Juan F.; García-Fernández, Alba; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (Blackwell Publishing, 2023-03)

[EN] A new method for senescent cell detection is described, which is based on lipofuscin labeling with a fluorescent reporter through a biorthogonal strain-promoted azide-alkyne cycloaddition. The sensing protocol involves ...