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Listar por autor "Boada Acosta, Yadira Fernanda"

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A systems engineering approach to model, tune and test synthetic gene circuits

Boada Acosta, Yadira Fernanda (Universitat Politècnica de València, 2018-11-16)

La biología sintética se define como la ingeniería de la biología: el (re)diseño y construcción de nuevas partes, dispositivos y sistemas biológicos para realizar nuevas funciones con fines útiles, que se basan en principios ...
Advancements in synthetic biology-based bacterial cancer therapy: A modular design approach

Arboleda-García, Andrés; Alarcon-Ruiz, Ivan; Boada-Acosta, Lissette; Boada-Acosta, Yadira Fernanda; Vignoni, Alejandro; Jantus-Lewintre, Eloisa (Elsevier, 2023-10)

[EN] Synthetic biology aims to program living bacteria cells with artificial genetic circuits for user-defined functions, transforming them into powerful tools with numerous applications in various fields, including oncology. ...
Análisis y ajuste de un seguidor genético sintético de señales biomoleculares mediante la aplicación de técnicas de optimización multiobjetivo

Montalar Mendoza, Aida-Pilar (Universitat Politècnica de València, 2019-10-07)

[ES] La biología sintética permite reconstruir o diseñar sistemas biológicos mediante modelos y una serie de métodos y herramientas con fines específicos como podría ser predecir el comportamiento que presentan. En este ...
Contractivity of a genetic circuit with internal feedback and cell-to-cell communication

Picó-Marco, Enric; Boada-Acosta, Yadira Fernanda; Picó, Jesús; Vignoni, Alejandro (Elsevier, 2016)

[EN] We consider a realistic model of the synthetic gene circuit combining cell-to-cell communication system via quorum sensing, and a synthetic repressible promoter implementing intracellular negative feedback control. ...
Design and implementation of digital twins of synthetic inducible gene expression circuits

Pushkareva, Anna (Universitat Politècnica de València, 2023-09-06)

[ES] En biología sintética, se emplea el ciclo iterativo de diseño (o re-diseño), construcción, prueba y aprendizaje (DBTL) de circuitos genéticos con el objetivo de modificar su función y crear microorganismos que presenten ...
Diseño de un dispositivo automatizado de intercambio de placas entre un robot de manejo de líquidos y un lector de fluorescencia

Asensi Devesa, Adrián (Universitat Politècnica de València, 2023-09-12)

[ES] La automatización de protocolos en biología sintética es clave para mejorar el rendimiento de los experimentos y permitir la reproducibilidad y la estandarización. Los robots de manipulación de líquidos y los lectores ...
Diseño e implementación de un controlador proporcional-integral (PI) para el control de la producción de proteínas

Monfort Llorens, Roger (Universitat Politècnica de València, 2019-09-30)

[ES] La biología sintética permite la construcción de circuitos genéticos con un comportamiento deseado, modificando y combinando diferentes elementos genéticos que existen en la naturaleza. El control y la regulación de ...
Diseño y aplicabilidad de un circuito genético basado en el control antitético en la síntesis de proteínas y metabolitos

Fraile López, Ana (Universitat Politècnica de València, 2020-09-08)

[ES] La biología sintética toma conceptos de ingeniería para el diseño y la construcción de circuitos genéticos con un comportamiento deseado, modificando y combinando diferentes elementos genéticos que ya existen en la ...
Engineered Control of Genetic Variability Reveals Interplay among Quorum Sensing, Feedback Regulation, and Biochemical Noise

Boada-Acosta, Yadira Fernanda; Vignoni, Alejandro; Picó, Jesús (American Chemical Society, 2017)

[EN] Stochastic fluctuations in gene expression trigger both beneficial and harmful consequences for cell behavior. Therefore, achieving a desired mean protein expression level while minimizing noise is of interest ...
Extended metabolic biosensor design for dynamic pathway regulation of cell factories

Boada-Acosta, Yadira Fernanda; Vignoni, Alejandro; Picó, Jesús; Carbonell, Pablo (Elsevier (Cell Press), 2020-07-24)

[EN] Transcription factor-based biosensors naturally occur in metabolic pathways to maintain cell growth and to provide a robust response to environmental fluctua-tions. Extended metabolic biosensors, i.e., the cascading ...
Gene expression modelling and simulation. Model reduction and noise

Boada Acosta, Yadira Fernanda (Universitat Politècnica de València, 2014-06-26)

[ES] Este trabajo aborda metodologías de modelado para el análisis y diseño de redes sintéticas de genes. Nuestro modelo para la bacteria E. coli. incluye: i) quorum sensing como un mecanismo de comunicación entre células ...
Gene Expression Space Shapes the Bioprocess Trade-Offs among Titer, Yield and Productivity

Santos-Navarro, Fernando Nóbel; Boada-Acosta, Yadira Fernanda; Vignoni, Alejandro; Picó, Jesús (MDPI AG, 2021-07)

[EN] Optimal gene expression is central for the development of both bacterial expression systems for heterologous protein production, and microbial cell factories for industrial metabolite production. Our goal is to fulfill ...
Integración de un modelo de carga metabólica en el análisis computacional de un circuito genético sintético

Oleas Palacios, Liliana Gricel (Universitat Politècnica de València, 2018-02-09)

In this project Weibe & Oyarzún¿s metabolic burden model will be integrated in the dynamic model of synthetic gene circuits. A circuit for control of protein expression, and a incoherent feedforwad one will be used. The ...
Modelado de sistemas bioquímicos: De la Ley de Acción de Masas a la Aproximación Lineal del Ruido

Picó Marco, Jesús Andrés; Vignoni, Alejandro; Picó i Marco, Enric; Boada Acosta, Yadira Fernanda (Universitat Politècnica de València, 2015-07-10)

[EN] In the last decade we have witnessed a growing application of engineering techniques to biology. Areas such as Systems Biology or, more recently, Synthetic Biology, get more and more attention from the engineers. ...
Modeling and Optimization of a Molecular Biocontroller for the Regulation of Complex Metabolic Pathways

Boada-Acosta, Yadira Fernanda; Santos-Navarro, Fernando Nóbel; Picó, Jesús; Vignoni, Alejandro (Frontiers Media SA, 2022-03-29)

[EN] Achieving optimal production in microbial cell factories, robustness against changing intracellular and environmental perturbations requires the dynamic feedback regulation of the pathway of interest. Here, we consider ...
Multi-objective optimization framework to obtain model-based guidelines for tuning biological synthetic devices: an adaptive network case

Boada Acosta, Yadira Fernanda; Reynoso Meza, Gilberto; Picó Marco, Jesús Andrés; Vignoni, Alejandro (BioMed Central, 2016-03-11)

Background: Model based design plays a fundamental role in synthetic biology. Exploiting modularity, i.e. using biological parts and interconnecting them to build new and more complex biological circuits is one of the key ...
Multicolor plate reader fluorescence calibration

Beal, Jacob; Telmer, Cheryl A.; Vignoni, Alejandro; Boada-Acosta, Yadira Fernanda; Baldwin, Geoff S.; Hallett, Liam; Lee, Taeyang; Selvarajah, Vinoo; Billerbeck, Sonja; Brown, Bradley; Cai, Guo-nan; Cai, Liang; Eisenstein, Edward; Kiga, Daisuke; Ross, David (Oxford University Press, 2022-02-02)

[EN] Plate readers are commonly used to measure cell growth and fluorescence, yet the utility and reproducibility of plate reader data is limited by the fact that it is typically reported in arbitrary or relative units. ...
Multiobjective Identification of a Feedback Synthetic Gene Circuit

Boada-Acosta, Yadira Fernanda; Vignoni, Alejandro; Picó, Jesús (Institute of Electrical and Electronics Engineers, 2020-01)

[EN] Kinetic (i.e., dynamic) semimechanistic models based on the first principles are particularly important in systems and synthetic biology since they can explain and predict the functional behavior that emerges from the ...
Optimization Alternatives for Robust Model-based Design of Synthetic Biological Circuits

Boada-Acosta, Yadira Fernanda; Pitarch Pérez, Jose Luis; Vignoni, Alejandro; Reynoso Meza, Gilberto; Picó, Jesús (Elsevier, 2016)

[EN] Synthetic biology is reaching the situation where tuning devices by hand is no longer possible due to the complexity of the biological circuits being designed. Thus, mathematical models need to be used in order, not ...
Parameter Identification in Synthetic Biological Circuits Using Multi-Objective Optimization

Boada-Acosta, Yadira Fernanda; Vignoni, Alejandro; Reynoso Meza, Gilberto; Picó, Jesús (Elsevier, 2016)

[EN] Synthetic biology exploits the of mathematical modeling of synthetic circuits both to predict the behavior of the designed synthetic devices, and to help on the selection of their biological coin portents. The increasing ...