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Listar por autor "Jiménez Gambín, Sergio"

Mostrando ítems 1-13 de 13

Acoustic Holograms for Bilateral Blood-Brain Barrier Opening in a Mouse Model

Jiménez-Gambín, Sergio; Jimenez, Noe; Pouliopoulos, Antonios N.; Benlloch Baviera, Jose María; Konofagou, Elisa E.; Camarena Femenia, Francisco (Institute of Electrical and Electronics Engineers, 2022-04)

[EN] Transcranial focused ultrasound (FUS) in conjunction with circulating microbubbles injection is the sole non-invasive technique that temporally and locally opens the blood-brain barrier (BBB), allowing targeted drug ...
Desarrollo de un sistema ultrasónico de potencia para aplicaciones médicas en animales pequeños

Bailén Marcos, Raquel (Universitat Politècnica de València, 2017-09-11)

El objetivo de este proyecto es el diseño, desarrollo y calibración de un sistema de haces de ultrasonidos focalizados de potencia aplicado en experimentos médicos para animales pequeños. Se diseñará el emisor y el ...
Efecto del método de definición de las propiedades acústicas de cráneo humano en la propagación focalizada de ultrasonidos

Jiménez-Gambín, Sergio; Jimenez, Noe; Camarena Femenia, Francisco (SOCIEDAD ESPAÑOLA DE ACUSTICA, 2019-07-16)

[EN] Combination of focused ultrasound and microbubbles is a non-ionizing technique for neurodegenerative diseases treatment allowing the blood-brain barrier opening locally, transiently, non-invasively and safely. In this ...
Estudios sobre la propagación transcraneal de ultrasonidos

Jiménez Gambín, Sergio (Universitat Politècnica de València, 2016-10-21)

Algunas enfermedades neurodegenerativas como el Alzheimer o el Parkinson se podrían tratar combinando los ultrasonidos focalizados con la técnica de inyección de microburbujas, permitiendo así la apertura de la BHE ...
First in-vivo Demonstration of Bilateral Blood-Brain Barrier Opening Using Acoustic Holograms in Mice

Jiménez-Gambín, Sergio; Jimenez, Noe; Benlloch Baviera, Jose María; Camarena Femenia, Francisco; Pouliopoulos, Antonios N.; Konofagou, Elisa E. (IEEE, 2020-09-11)

[EN] Focused ultrasound (FUS) with microbubbles allows for non-invasive targeted drug delivery into the central nervous system (CNS) by temporally and locally disrupting the bloodbrain barrier (BBB). However, current FUS ...
Generating Bessel beams with broad depth-of-field by using phase-only acoustic holograms

Jiménez-Gambín, Sergio; Jimenez, Noe; Benlloch Baviera, Jose María; Camarena Femenia, Francisco (Nature Publishing Group, 2019-12-27)

[EN] We report zero-th and high-order acoustic Bessel beams with broad depth-of-field generated using acoustic holograms. While the transverse field distribution of Bessel beams generated using traditional passive methods ...
Hologramas acústicos multifocales para el tratamiento con ultrasonidos de estructuras cerebrales profundas

Andrés-Bautista, Diana; Jiménez-Gambín, Sergio; Jimenez, Noe; Camarena Femenia, Francisco (SOCIEDAD ESPAÑOLA DE ACUSTICA, 2021)

[EN] Focused ultrasound has acquired great importance in the treatment of neurological diseases due to its ability to generate therapeutic effects in a in precise, non-invasive, and non-ionizing way. However, focusing ...
Holograms to Focus Arbitrary Ultrasonic Fields through the Skull

Jiménez-Gambín, Sergio; Jimenez, Noe; Benlloch Baviera, Jose María; Camarena Femenia, Francisco (American Physical Society, 2019-07-10)

[EN] We report 3D-printed acoustic holographic lenses for the formation of ultrasonic fields of complex spatial distribution inside the skull. Using holographic lenses, we experimentally, numerically and theoretically ...
Multifocal acoustic holograms for deep-brain neuromodulation and BBB opening

Andrés, Diana; Jiménez-Gambín, Sergio; Jimenez, Noe; Camarena Femenia, Francisco (IEEE, 2020-09-11)

[EN] Single-element focused ultrasound devices have demonstrated its ability to non-invasively open the Blood Brain Barrier. However, skull irregularities and absorption produce strong aberrations in the ultrasound focus. ...
On the Evaluation of the Suitability of the Materials Used to 3D Print Holographic Acoustic Lenses to Correct Transcranial Focused Ultrasound Aberrations

Ferri García, Marcelino; Bravo Plana-Sala, José María; Redondo, Javier; Jiménez-Gambín, Sergio; Jimenez, Noe; Camarena Femenia, Francisco; Sánchez-Pérez, Juan Vicente (MDPI AG, 2019-09)

[EN] The correction of transcranial focused ultrasound aberrations is a relevant topic for enhancing various non-invasive medical treatments. Presently, the most widely accepted method to improve focusing is the emission ...
Transcranial acoustic holograms for arbitrary fields generation using focused ultrasound into the brain

Jiménez-Gambín, Sergio; Jimenez, Noe; Benlloch Baviera, Jose María; Camarena Femenia, Francisco (Acoustical Society of America, 2019-09-06)

[EN] We present 3D printed holographic lenses that correct the aberrations of the skull and, simultaneously, produce arbitrary ultrasonic fields with the geometry of brain structures. Using experimental techniques on a ...
Transcranial focusing of ultrasonic vortices by acoustic holograms

Jiménez-Gambín, Sergio; Jimenez, Noe; Camarena Femenia, Francisco (American Physical Society, 2020-11-30)

[EN] Acoustic vortex beams have great potential for contactless particle manipulation and torque-based biomedical applications. However, when focusing acoustic waves through aberration layers such as the human skull at ...
Transcranial Ultrasound Holograms for the Blood-Brain Barrier Opening

Jiménez Gambín, Sergio (Universitat Politècnica de València, 2021-09-02)

[ES] El tratamiento de enfermedades neurológicas está muy limitado por la ineficiente penetración de los fármacos en el tejido cerebral dañado debido a la barrera hematoencefálica (BHE), lo que imposibilita mejorar la salud ...