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Listar por autor "Vivo Llorca, Gema"

Mostrando ítems 1-7 de 7

Gene-Directed Enzyme Prodrug Therapy by Dendrimer-Like Mesoporous Silica Nanoparticles against Tumor Cells

Candela-Noguera, Vicente; Vivo-Llorca, Gema; Díaz de Greñu, Borja; Alfonso, María; Aznar, Elena; Orzáez, Mar; Marcos Martínez, María Dolores; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (MDPI AG, 2021-05)

[EN] We report herein a gene-directed enzyme prodrug therapy (GDEPT) system using gated mesoporous silica nanoparticles (MSNs) in an attempt to combine the reduction of side effects characteristic of GDEPT with improved ...
Horseradish Peroxidase-Functionalized Gold Nanoconjugates for Breast Cancer Treatment Based on Enzyme Prodrug Therapy

Vivo-Llorca, Gema; Morella-Aucejo, Ángela; García-Fernández, Alba; Diez-Sánchez, Paula; Llopis-Lorente, Antoni; Orzáez, Mar; Martínez-Máñez, Ramón (Dove Medical Press, 2022-01-26)

[EN] Introduction: Breast cancer has the highest mortality rate among cancers in women. Patients suffering from certain breast cancers, such as triple-negative breast cancer (TNBC), lack effective treatments. This represents ...
Internalización y toxicidad de nanopartículas de sílice como vehículo de CRISPR en líneas tumorales de cáncer de mama

González Garrido, Jorge (Universitat Politècnica de València, 2018-09-28)

[ES] El cáncer de mama es el tipo de cáncer más diagnosticado en mujeres y supone su segunda causa de mortalidad. Los tumores de mama triple negativo (TNBC) son aquellos que carecen de expresión para los tres marcadores ...
Mesoporous silica and gold-based nanodevices: new controlled delivery platforms for biomedical applications

Vivo Llorca, Gema (Universitat Politècnica de València, 2021-07-26)

[ES] La presente tesis doctoral titulada "Mesoporous silica and gold-based nanodevices: new controlled delivery platforms for biomedical applications" se centra en el diseño, síntesis, caracterización y evaluación de ...
MUC1 Aptamer-Capped Mesoporous Silica Nanoparticles for Navitoclax Resistance Overcoming in Triple-Negative Breast Cancer

Vivo-Llorca, Gema; Candela-Noguera, Vicente; Alfonso-Navarro, María; García-Fernández, Alba; Orzáez, Mar; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (John Wiley & Sons, 2020-10-09)

[EN] Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. In the last years, navitoclax has emerged as a possible treatment for TNBC. Nevertheless, rapid navitoclax resistance onset has been ...
Nanodevices for the Efficient Codelivery of CRISPR-Cas9 Editing Machinery and an Entrapped Cargo: A Proposal for Dual Anti-Inflammatory Therapy

García-Fernández, Alba; Vivo-Llorca, Gema; Sancho, Mónica; García-Jareño, Alicia Belén; Ramírez-Jiménez, Laura; Barber-Cano, Eloísa; Murguía, Jose R.; Orzaez, Mar; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (The Royal Society of Chemistry, 2022-07)

[EN] In this article, we report one of the few examples of nanoparticles capable of simultaneously delivering CRISPR-Cas9 gene-editing machinery and releasing drugs for one-shot treatments. Considering the complexity of ...
Puesta a punto de un sistema de nanopartículas de sílice mesoporosa para edición génica basado en la tecnología CRISPR/Cas9

Vivo Llorca, Gema (Universitat Politècnica de València, 2017-10-25)

The aim of this project is to optimize a novel nanodispositive based on silica mesoporous nanoparticles (MSNs) for genome editing in human cell lines, using CRISPR/Cas9 technology. It focuses on the synthesis and ...