Pérez-Cervera, Laura; De Santis, Silvia; Marcos, Encarni; Ghorbanzad-Ghaziany, Zahra; Trouvé-Carpena, Alejandro; Selim, Mohamed Kotb; Pérez-Ramírez, Úrsula; Pfarr, Simone; Bach, Patrick; P Halli; Kiefer, Falk; Moratal, David; Kirsch, Peter; Sommer, Wolfgang H.; Canals, Santiago(BioMed Central Ltd., 2023-06-21)
[EN] IntroductionAlcohol dependence is characterized by a gradual reduction in cognitive control and inflexibility to contingency changes. The neuroadaptations underlying this aberrant behavior are poorly understood. Using ...
[EN] Alcohol use disorder (AUD) causes complex alterations in the brain that are poorly understood. The heterogeneity of drinking patterns and the high incidence of comorbid factors compromise mechanistic investigations ...
De Santis, Silvia; Cosa-Liñán, Alejandro; Garcia-Hernandez, Raquel; Dmytrenko, Lesia; Vargova, Lydia; Vorisek, Ivan; Stopponi, Serena; Bach, Patrick; Kirsch, Peter; Kiefer, Falk; Ciccocioppo, Roberto; Sykova, Eva; Moratal, David; Sommer, Wolfgang H.; Canals, Santiago(American Association for the Advancement of Science, 2020-06)
[EN] Already moderate alcohol consumption has detrimental long-term effects on brain function. However, how alcohol produces its potent addictive effects despite being a weak reinforcer is a poorly understood conundrum ...
Bach, Patrick; Weil, Georg; Pompili, Enrico; Hoffmann, Sabine; Hermann, Derik; Vollstädt-Klein, Sabine; Mann, Karl; Pérez-Ramírez, Úrsula; Moratal, David; Canals, Santiago; Dursun, Serdar M.; Greenshaw, Andrew J.; Kirsch, Peter; Kiefer, Falk; Sommer, Wolfgang H.(Blackwell Publishing, 2020-01)
[EN] During the first weeks of abstinence, alcohol craving in patients may increase or "incubate." We hypothesize that Naltrexone (NTX) blocks this incubation effect. Here, we compared NTX effects on neural alcohol cue ...
[EN] Alcohol use disorder (AUD) is a complex condition representing a leading risk factor for death, disease and disability. Its high prevalence and severe health consequences make necessary a better understanding of the ...
[EN] Robust neuroimaging markers of neuropsychiatric disorders have proven difficult to obtain. In alcohol use disorders, profound brain structural deficits can be found in severe alcoholic patients, but the heterogeneity ...
[EN] Human imaging data suggest that the motivational processes associated with alcohol reward are reflected in the patterns of neural activation after alcohol or alcohol-related cues. In animal models of alcohol drinking, ...